ING3

ING3

Identifiers

ING3, Eaf4, ING2, MEAF4, p47inhibitor of growth family member 3

External IDs

OMIM: 607493; MGI: 1919027; GeneCards: ING3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1X4I

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q31.31	Start	120,950,763 bp^[1]
Band	7q31.31	End	120,977,216 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 A3.1	Start	21,949,570 bp^[2]
Band	6\|6 A3.1	End	21,976,037 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

trabecular bone

monocyte

testicle

Achilles tendon

bone marrow

tail of epididymis

gonad

germinal epithelium

parietal pleura

Top expressed in

zygote

secondary oocyte

genital tubercle

tail of embryo

spermatid

granulocyte

primary oocyte

Rostral migratory stream

medial ganglionic eminence

ventricular zone

More reference expression data


More reference expression data

Gene ontology
Molecular function	histone acetyltransferase activity methylated histone binding metal ion binding
Cellular component	Piccolo NuA4 histone acetyltransferase complex nucleus nucleoplasm Swr1 complex NuA4 histone acetyltransferase complex
Biological process	histone H4 acetylation histone H2A acetylation regulation of growth regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of apoptotic process chromatin organization
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


54556


71777


ENSG00000071243


ENSMUSG00000029670


Q9NXR8


Q8VEK6

RefSeq (mRNA)


NM_198267 NM_019071 NM_198266


NM_023626 NM_001311061

RefSeq (protein)


NP_061944 NP_938008


NP_001297990 NP_076115

Location (UCSC)

Chr 7: 120.95 – 120.98 Mb

Chr 6: 21.95 – 21.98 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene.^[5]^[6]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000071243 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029670 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, Nagai N, Nishizaki K, Shimizu K (Jun 2002). "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–70. doi:10.1038/sj.onc.1205540. PMID 12080476.
^ ^a ^b "Entrez Gene: ING3 inhibitor of growth family, member 3".

Further reading

Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagashima M, Shiseki M, Pedeux RM, et al. (2003). "A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis". Oncogene. 22 (3): 343–50. doi:10.1038/sj.onc.1206115. PMID 12545155.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Wang Y, Dai DL, Martinka M, Li G (2007). "Prognostic significance of nuclear ING3 expression in human cutaneous melanoma". Clin. Cancer Res. 13 (14): 4111–6. doi:10.1158/1078-0432.CCR-07-0408. PMID 17634537.

v t e PDB gallery
1x4i: Solution structure of PHD domain in inhibitor of growth protein 3 (ING3)

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.