ING1

ING1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QIC
Identifiers
Aliases	ING1, p24ING1c, p33, p33p33ING1b, p47, p47ING1a, inhibitor of growth family member 1
External IDs	OMIM: 601566; MGI: 1349481; HomoloGene: 40119; GeneCards: ING1; OMA:ING1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	110,723,339 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	11,613,251 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; ventricular zone; ; gonad; ; left testis; ; right testis; ; monocyte; ; endothelial cell; ; blood; ; decidua;
	Top expressed in
	primitive streak; ; genital tubercle; ; Rostral migratory stream; ; tail of embryo; ; secondary oocyte; ; ureter; ; vas deferens; ; medullary collecting duct; ; abdominal wall; ; primary oocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	methylated histone binding; protein binding; metal ion binding;
Cellular component	nucleus;
Biological process	regulation of cell death; cell cycle; negative regulation of cell growth; negative regulation of cell population proliferation; positive regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	3621
	26356
	ENSG00000153487
	ENSMUSG00000045969
	Q9UK53
	Q9QXV3
	NM_198219; NM_001267728; NM_005537; NM_198217; NM_198218
NM_011919; NM_001302451; NM_001302457; NM_001302458; NM_001302459;
	NM_001302460
	NP_001254657; NP_005528; NP_937860; NP_937861; NP_937862
NP_001289380; NP_001289386; NP_001289387; NP_001289388; NP_001289389;
	NP_036049
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.^[5]^[6]^[7]

Function

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.^[7]

One of the isoforms of ING1 (p33(ING1) is involved in the modulation of DNA repair.^[8] It appears that p33(ING1) cooperates with p53 in nucleotide excision repair.^[8] Also, proliferating cell nuclear antigen (PCNA) interacts with p33(ING1b) in the elimination of UV-damaged cells through the induction of programmed cell death (apoptosis).^[9]

Location on Chromosome 13

ING1 is located near the following genes on Chromosome 13

CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
COL4A2: A2 Subunit of type IV collagen
RAB20: Potential regulator of Connexin 43 trafficking.
CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

Interactions

ING1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153487 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045969 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Dec 1996). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nature Genetics. 14 (4): 415–20. doi:10.1038/ng1296-415. PMID 8944021. S2CID 10173092.
^ Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenetics and Cell Genetics. 76 (3–4): 176–8. doi:10.1159/000134539. PMID 9186514.
^ ^a ^b "Entrez Gene: ING1 inhibitor of growth family, member 1".
^ ^a ^b Cheung KJ, Mitchell D, Lin P, Li G (July 2001). "The tumor suppressor candidate p33(ING1) mediates repair of UV-damaged DNA". Cancer Res. 61 (13): 4974–7. PMID 11431327.
^ Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (October 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". J Cell Sci. 114 (Pt 19): 3455–62. doi:10.1242/jcs.114.19.3455. PMID 11682605.
^ ^a ^b Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K (Aug 2002). "Human ING1 proteins differentially regulate histone acetylation". The Journal of Biological Chemistry. 277 (33): 29832–9. doi:10.1074/jbc.M200197200. PMID 12015309.
^ Xin H, Yoon HG, Singh PB, Wong J, Qin J (Mar 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". The Journal of Biological Chemistry. 279 (10): 9539–46. doi:10.1074/jbc.M311587200. PMID 14665632.
^ ^a ^b ^c ^d ^e Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–48. doi:10.1128/mcb.22.3.835-848.2002. PMC 133546. PMID 11784859.
^ Leung KM, Po LS, Tsang FC, Siu WY, Lau A, Ho HT, Poon RY (Sep 2002). "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Research. 62 (17): 4890–3. PMID 12208736.
^ Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV (Jan 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature. 391 (6664): 295–8. Bibcode:1998Natur.391..295G. doi:10.1038/34675. PMID 9440695. S2CID 4429461.
^ Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (Oct 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". Journal of Cell Science. 114 (Pt 19): 3455–62. doi:10.1242/jcs.114.19.3455. PMID 11682605.