HOXC12

HOXC12
Identifiers
Aliases	HOXC12, HOC3F, HOX3, HOX3F, homeobox C12
External IDs	OMIM: 142975; MGI: 96194; HomoloGene: 7769; GeneCards: HOXC12; OMA:HOXC12 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,958,956 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,847,044 bp
RNA expression pattern
	Top expressed in
	testicle; ; skin of leg; ; sural nerve; ; popliteal artery; ; tibial arteries; ; skin of abdomen; ; subcutaneous adipose tissue; ; olfactory zone of nasal mucosa; ; mammary gland; ; female breast;
	Top expressed in
	tail of embryo; ; genital tubercle; ; neural tube; ; hair follicle; ; mesenchyme; ; skeleton; ; leg;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3228
	15421
	ENSG00000123407
	ENSMUSG00000050328
	P31275
	Q8K5B8
	NM_173860
	NM_010463
	NP_776272
	NP_034593
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox C12 is a protein that in humans is encoded by the HOXC12 gene.^[5]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123407 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050328 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Homeobox C12". Retrieved 2011-11-11.

Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (February 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (December 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (October 1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters. 415 (3): 263–7. Bibcode:1997FEBSL.415..263F. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979. S2CID 26075369.