HIVEP3

HIVEP3
Identifiers
Aliases	HIVEP3, Hivep3, 2900056N03Rik, A130075N07, AI848000, E030045D18Rik, KBP-1, KBP1, Rc, Schnurri-3, Shn3, Zas3, ZNF40C, human immunodeficiency virus type I enhancer binding protein 3, Kappa Recognition Component (Krc), KRC, HIVEP zinc finger 3
External IDs	OMIM: 606649; MGI: 106589; HomoloGene: 7803; GeneCards: HIVEP3; OMA:HIVEP3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	42,035,925 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	119,995,242 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; endothelial cell; ; Brodmann area 23; ; cartilage tissue; ; parietal pleura; ; primary visual cortex; ; granulocyte; ; middle temporal gyrus; ; entorhinal cortex; ; germinal epithelium;
	Top expressed in
	gastrula; ; medial geniculate nucleus; ; Rostral migratory stream; ; subiculum; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; substantia nigra; ; trigeminal ganglion; ; anterior amygdaloid area; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	multicellular organism development; skeletal muscle cell differentiation; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription by RNA polymerase II; signal transduction; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	59269
	16656
	ENSG00000127124
	ENSMUSG00000028634
	Q5T1R4
	A2A884
	NM_001127714; NM_024503
	NM_010657
	NP_001121186; NP_078779
	NP_034787
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.^[5]^[6]

Function

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]^[6]

It regulates osteoblasts.^[7]

Interactions

HIVEP3 has been shown to interact with TRAF1^[8] and TRAF2.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127124 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028634 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hicar MD, Liu Y, Allen CE, Wu LC (January 2001). "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2". Genomics. 71 (1): 89–100. doi:10.1006/geno.2000.6425. PMID 11161801.
^ ^a ^b "Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3".
^ Glimcher LH, Jones DC, Wein MN (November 2007). "Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3". Annals of the New York Academy of Sciences. 1116 (1): 174–181. Bibcode:2007NYASA1116..174G. doi:10.1196/annals.1402.044. PMID 18083927. S2CID 25260678.
^ ^a ^b Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (January 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Molecular Cell. 9 (1): 121–131. doi:10.1016/S1097-2765(01)00434-8. PMID 11804591.