ELK4

ELK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BC7, 1BC8, 1HBX, 1K6O
Identifiers
Aliases	ELK4, SAP1, ETS transcription factor, ETS transcription factor ELK4
External IDs	OMIM: 600246; MGI: 102853; HomoloGene: 1492; GeneCards: ELK4; OMA:ELK4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	205,632,011 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,960,350 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; epithelium of colon; ; sperm; ; epithelium of nasopharynx; ; skin of thigh; ; skin of hip; ; biceps brachii; ; superficial temporal artery; ; parietal pleura; ; seminal vesicula;
	Top expressed in
	saccule; ; Paneth cell; ; otic placode; ; semi-lunar valve; ; hair follicle; ; aortic valve; ; blood; ; conjunctival fornix; ; thymus; ; ankle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; sequence-specific DNA binding; chromatin binding; transcription coregulator activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus; cytosol;
Biological process	histone H3 deacetylation; cell differentiation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2005
	13714
	ENSG00000158711
	ENSMUSG00000026436
	P28324
	P41158
	NM_001973; NM_021795
NM_007923; NM_001376954; NM_001376955; NM_001376956; NM_001376957;
	NM_001376958; NM_001376959
	NP_001964; NP_068567; NP_068567.1
NP_031949; NP_001363883; NP_001363884; NP_001363885; NP_001363886;
	NP_001363887; NP_001363888
	Wikidata
View/Edit Human	View/Edit Mouse

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.^[5]^[6]^[7]

Function

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.^[7]