RAR-related orphan receptor beta

RORB
Identifiers
Aliases	RORB, NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1, RAR-related orphan receptor beta, RAR related orphan receptor B, EIG15
External IDs	OMIM: 601972; MGI: 1343464; HomoloGene: 38250; GeneCards: RORB; OMA:RORB - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	74,693,177 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	19,088,560 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; Parietal Lobe; ; postcentral gyrus; ; retinal pigment epithelium; ; primary visual cortex; ; superior frontal gyrus; ; entorhinal cortex; ; endometrium;
	Top expressed in
	internal granular layer; ; medial geniculate nucleus; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; Rostral migratory stream; ; retina; ; neural layer of retina; ; retinal pigment epithelium; ; lumbar subsegment of spinal cord; ; posterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; zinc ion binding; transcription factor binding; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; melatonin receptor activity;
Cellular component	nucleoplasm; nucleus;
Biological process	cellular response to retinoic acid; regulation of transcription, DNA-templated; response to stimulus; rhythmic process; retinal cone cell development; negative regulation of osteoblast differentiation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; multicellular organism development; regulation of circadian rhythm; retinal rod cell development; eye photoreceptor cell development; transcription initiation from RNA polymerase II promoter; negative regulation of transcription, DNA-templated; visual perception; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway; amacrine cell differentiation; retina development in camera-type eye; positive regulation of transcription by RNA polymerase II; G protein-coupled receptor signaling pathway; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6096
	225998
	ENSG00000198963
	ENSMUSG00000036192
	Q92753; Q58EY0
	Q8R1B8
	NM_006914; NM_001365023
	NM_001043354; NM_001289921; NM_146095
	NP_008845; NP_001351952
	NP_001036819; NP_001276850; NP_666207
	Wikidata
View/Edit Human	View/Edit Mouse

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.^[5]

Function

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside-diphosphate kinase involved in organogenesis and differentiation.^[6]

In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.^[7]

A mutation in this gene also results in the loss of spinal cord interneurons and of saltatorial locomotion,^[8] a type of hopping gait that in mammals can be found in rabbits, hares, kangaroos, and some species of rodents.

Interactions

RAR-related orphan receptor beta has been shown to interact with NME1.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198963 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036192 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G (March 1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes & Development. 8 (5): 538–553. doi:10.1101/gad.8.5.538. PMID 7926749.
^ "Entrez Gene: RORB RAR-related orphan receptor B".
^ Jabaudon D, Shnider SJ, Tischfield DJ, Galazo MJ, Macklis JD (May 2012). "RORβ induces barrel-like neuronal clusters in the developing neocortex". Cerebral Cortex. 22 (5): 996–1006. doi:10.1093/cercor/bhr182. PMC 3328343. PMID 21799210.
^ Carneiro M, Vieillard J, Andrade P, Boucher S, Afonso S, Blanco-Aguiar JA, et al. (March 2021). "A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits". PLOS Genetics. 17 (3): e1009429. doi:10.1371/journal.pgen.1009429. PMC 7993613. PMID 33764968.
^ Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochemical and Biophysical Research Communications. 227 (1): 82–87. doi:10.1006/bbrc.1996.1471. PMID 8858107.

External links

orphan+nuclear+receptor+ROR-beta at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198963 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036192 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7926749-5] Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G (March 1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes & Development. 8 (5): 538–553. doi:10.1101/gad.8.5.538. PMID 7926749.

[entrez-6] "Entrez Gene: RORB RAR-related orphan receptor B".

[pmid21799210-7] Jabaudon D, Shnider SJ, Tischfield DJ, Galazo MJ, Macklis JD (May 2012). "RORβ induces barrel-like neuronal clusters in the developing neocortex". Cerebral Cortex. 22 (5): 996–1006. doi:10.1093/cercor/bhr182. PMC 3328343. PMID 21799210.

[8] Carneiro M, Vieillard J, Andrade P, Boucher S, Afonso S, Blanco-Aguiar JA, et al. (March 2021). "A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits". PLOS Genetics. 17 (3): e1009429. doi:10.1371/journal.pgen.1009429. PMC 7993613. PMID 33764968.

[pmid8858107-9] Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochemical and Biophysical Research Communications. 227 (1): 82–87. doi:10.1006/bbrc.1996.1471. PMID 8858107.

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RAR-related orphan receptor beta

Function

Interactions

See also

References

Further reading

External links

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