IKZF3

IKZF3
Identifiers
Aliases	IKZF3, AIO, AIOLOS, ZNFN1A3, IKAROS family zinc finger 3, IMD84
External IDs	OMIM: 606221; MGI: 1342542; HomoloGene: 8269; GeneCards: IKZF3; OMA:IKZF3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,864,312 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,436,857 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; epithelium of nasopharynx; ; bone marrow cells; ; thymus; ; spleen; ; blood; ; tonsil; ; superficial temporal artery; ; appendix;
	Top expressed in
	mesenteric lymph nodes; ; thymus; ; spleen; ; blood; ; lumbar subsegment of spinal cord; ; female urethra; ; subcutaneous adipose tissue; ; submandibular gland; ; granulocyte; ; transitional epithelium of urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein homodimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; protein binding; protein heterodimerization activity; nucleic acid binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; plasma membrane; nucleus; nucleoplasm; cytosol;
Biological process	regulation of apoptotic process; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; B cell activation; regulation of B cell proliferation; regulation of lymphocyte differentiation; mesoderm development; regulation of B cell differentiation; positive regulation of transcription by RNA polymerase II; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	22806
	22780
	ENSG00000161405
	ENSMUSG00000018168
	Q9UKT9
	O08900
NM_183232; NM_001257408; NM_001257409; NM_001257410; NM_001257411;
	NM_001257412; NM_001257413; NM_001257414; NM_001284514; NM_001284515; NM_001284516; NM_012481; NM_183228; NM_183229; NM_183230; NM_183231
	NM_011771
NP_001244337; NP_001244338; NP_001244339; NP_001244340; NP_001244341;
	NP_001244342; NP_001244343; NP_001271443; NP_001271444; NP_001271445; NP_036613; NP_899051; NP_899052; NP_899053; NP_899054; NP_899055
	NP_035901
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene.^[5]^[6]^[7]

Function

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.^[7]