HOXC10

HOXC10
Identifiers
Aliases	HOXC10, HOX3I, homeobox C10
External IDs	OMIM: 605560; MGI: 96192; HomoloGene: 9680; GeneCards: HOXC10; OMA:HOXC10 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,990,279 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,880,328 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; buccal mucosa cell; ; renal medulla; ; popliteal artery; ; tibial arteries; ; tibialis anterior muscle; ; human kidney; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; Achilles tendon;
	Top expressed in
	tail of embryo; ; knee joint; ; muscle of thigh; ; medial head of gastrocnemius muscle; ; lumbar subsegment of spinal cord; ; quadriceps femoris muscle; ; tibialis anterior muscle; ; vastus lateralis muscle; ; genital tubercle; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cyclin-dependent protein kinase activating kinase holoenzyme complex; nucleus; nuclear body; nucleoplasm;
Biological process	multicellular organism development; skeletal system development; proximal/distal pattern formation; neuromuscular process; regulation of transcription, DNA-templated; embryonic limb morphogenesis; transcription, DNA-templated; positive regulation of cell population proliferation; anterior/posterior pattern specification; spinal cord motor neuron cell fate specification; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3226
	209448
	ENSG00000180818
	ENSMUSG00000022484
	Q9NYD6
	P31257
	NM_017409
	NM_010462
	NP_059105
	NP_034592
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.^[5]^[6]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.^[6]