ARID3B

ARID3B
Identifiers
Aliases	ARID3B, BDP, DRIL2, AT-rich interaction domain 3B
External IDs	OMIM: 612457; MGI: 1930768; HomoloGene: 4721; GeneCards: ARID3B; OMA:ARID3B - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,598,131 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,744,076 bp
RNA expression pattern
	Top expressed in
	oocyte; ; gonad; ; blood; ; left testis; ; granulocyte; ; right testis; ; secondary oocyte; ; testicle; ; bone marrow cells; ; placenta;
	Top expressed in
	tail of embryo; ; epiblast; ; granulocyte; ; genital tubercle; ; Rostral migratory stream; ; yolk sac; ; zygote; ; neural layer of retina; ; embryo; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; biological process;
	Sources:Amigo / QuickGO
Orthologs
	10620
	56380
	ENSG00000179361
	ENSMUSG00000004661
	Q8IVW6
	Q9Z1N7
	NM_001307939; NM_006465
	NM_019689; NM_001379353
	NP_001294868; NP_006456
	NP_062663; NP_001366282
	Wikidata
View/Edit Human	View/Edit Mouse

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.^[5]

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.^[5]