HOXB7

HOXB7
Identifiers
Aliases	HOXB7, HHO.C1, HOX2, HOX2C, Hox-2.3, homeobox B7
External IDs	OMIM: 142962; MGI: 96188; HomoloGene: 55828; GeneCards: HOXB7; OMA:HOXB7 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,633,572 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	96,180,988 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; mucosa of ileum; ; mucosa of transverse colon; ; caput epididymis; ; seminal vesicula; ; mucosa of sigmoid colon; ; tail of epididymis; ; buccal mucosa cell; ; renal medulla; ; endometrium;
	Top expressed in
	tail of embryo; ; right kidney; ; Hindgut; ; neural tube; ; intestinal villus; ; Ileal epithelium; ; embryo; ; proximal tubule; ; allantois; ; genital tubercle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;
Cellular component	nucleus; nucleoplasm; cytosol; nuclear body;
Biological process	multicellular organism development; embryonic skeletal system morphogenesis; myeloid cell differentiation; positive regulation of branching involved in ureteric bud morphogenesis; regulation of transcription, DNA-templated; transcription, DNA-templated; anterior/posterior pattern specification; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3217
	15415
	ENSG00000260027
	ENSMUSG00000038721
	P09629
	P09024
	NM_004502
	NM_010460
	NP_004493
	NP_034590
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.^[5]^[6]

Function

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.^[7]

Interactions

HOXB7 has been shown to interact with PBX1^[8] and CREB-binding protein.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000260027 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038721 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
^ "Entrez Gene: HOXB7 homeobox B7".
^ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–674. doi:10.1101/gad.9.6.663. PMID 7729685.
^ Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V (July 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene. 18 (27): 4007–4014. doi:10.1038/sj.onc.1202776. PMID 10435624.

Baier LJ, Hannibal MC, Hanley EW, Nabel GJ (1991). "Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain". Blood. 78 (4): 1047–1055. doi:10.1182/blood.V78.4.1047.1047. PMID 1678287.
Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation. 45 (1): 61–69. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–197. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ (1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8536–8540. Bibcode:1989PNAS...86.8536S. doi:10.1073/pnas.86.21.8536. PMC 298317. PMID 2573064.
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (1989). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–10402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1989). "Organization of human class I homeobox genes". Genome. 31 (2): 745–756. doi:10.1139/g89-133. PMID 2576652.
Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E (1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–4918. Bibcode:1987PNAS...84.4914S. doi:10.1073/pnas.84.14.4914. PMC 305217. PMID 2885844.
Lill MC, Fuller JF, Herzig R, Crooks GM, Gasson JC (1995). "The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation". Blood. 85 (3): 692–697. doi:10.1182/blood.V85.3.692.bloodjournal853692. PMID 7530503.
Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–674. doi:10.1101/gad.9.6.663. PMID 7729685.
Corsetti MT, Levi G, Lancia F, Sanseverino L, Ferrini S, Boncinelli E, Corte G (1995). "Nucleolar localisation of three Hox homeoproteins". J. Cell Sci. 108 (1): 187–193. doi:10.1242/jcs.108.1.187. PMID 7738096.
Inamori K, Takeshita K, Chiba S, Yazaki Y, Hirai H (1993). "Identification of homeobox genes expressed in human T-lymphocytes". Biochem. Biophys. Res. Commun. 196 (1): 203–208. doi:10.1006/bbrc.1993.2235. PMID 8105782.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM (1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 900–905. Bibcode:1996PNAS...93..900M. doi:10.1073/pnas.93.2.900. PMC 40155. PMID 8570656.
Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–115. doi:10.1159/000134320. PMID 8646877.
Caré A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, Peschle C, Colombo MP (1996). "HOXB7 constitutively activates basic fibroblast growth factor in melanomas". Mol. Cell. Biol. 16 (9): 4842–4851. doi:10.1128/mcb.16.9.4842. PMC 231486. PMID 8756643.
LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (1997). "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains". Oncogene. 15 (17): 2059–2067. doi:10.1038/sj.onc.1201367. PMID 9366523.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Stelnicki EJ, Kömüves LG, Kwong AO, Holmes D, Klein P, Rozenfeld S, Lawrence HJ, Adzick NS, Harrison M, Largman C (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development". J. Invest. Dermatol. 110 (2): 110–115. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903.