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An isopeptide bond is a type of amide bond formed between a carboxyl group of one amino acid and an amino group of another. An isopeptide bond is the linkage...

chain. It can also be called a eupeptide bond to distinguish it from an isopeptide bond, which is another type of amide bond between two amino acids. When...

reacts with the protein SpyCatcher (12.3 kDa) to form an intermolecular isopeptide bond between the pair. DNA sequence encoding either SpyTag or SpyCatcher...

the addition of a methylmalonyl group to lysine residues spontaneous isopeptide bond formation, between lysine and aspartic acid or asparagine, as found...

Transglutaminases are enzymes that in nature primarily catalyze the formation of an isopeptide bond between γ-carboxamide groups ( -(C=O)NH2 ) of glutamine residue side...

to bind ubiquitin to lysine residues on the protein substrate via an isopeptide bond, cysteine residues through a thioester bond; serine, threonine, and...

transglutaminase enzyme is increased. Presence of isopeptide bonds in these structures: The presence of isopeptide bonds (the result of the transglutaminase reaction)...

2025. Lexhaller B, Ludwig C, Scherf KA (4 May 2020). "Identification of Isopeptides Between Human Tissue Transglutaminase and Wheat, Rye, and Barley Gluten...

enzyme that hydrolyzes isopeptide bonds, or amide bonds that occur outside the main chain in a polypeptide chain. Isopeptide bonds occur in the linkage...

ubiquitin, once it reaches its destination, ends up being attached by an isopeptide bond to a lysine residue, which is part of the target protein. E3 ligases...

reaction Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin This enzyme hydrolyses...

protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–21937...

LPXTGase. LPXTG Pili in Gram-positive bacteria contain spontaneously formed isopeptide bonds. These bonds provide enhanced mechanical and proteolytic stability...

"homocysteinylation" of protein lysine residues. HTL has been reported to form isopeptide bonds with lysine residues in substrate proteins, a post-translational...

a beta-linked Asp residue from the N-terminus of a polypeptide Other isopeptide bonds, e.g. gamma-glutamyl and beta-alanyl, are not hydrolysed. Haley...

and wool, skin, and cartilage. Disulfide bonds are common crosslinks. Isopeptide bond formation is another type of protein crosslink.[citation needed]...

with the sequence SKKSKPGDGKFGRGVKRG, whose N-terminal serine forms an isopeptide bond with the side chain of aspartate 8 and the C-terminal tail is threaded...

Pup is attached to specific lysine residues of substrate proteins by isopeptide bonds; this is called pupylation. It is then recognized by the protein...

acids of the C-terminus have been cleaved off to allow formation of an isopeptide bond between the C-terminal glycine residue of SUMO and an acceptor lysine...

conserved cysteine and histidine residues that catalyse the proteolysis of an isopeptide bond between a lysine residue of a target protein and a glycine residue...

(Spy0128) from Streptococcus pyogenes. Spy0128 contains two intramolecular isopeptide bonds, and to generate the isopeptag one of these bonds was split by removing...

interactions. DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are...

catalyze the crosslinking of proteins by epsilon-(gamma-glutamyl)lysine isopeptide bonds. Similarly to other transglutaminases, tTG consists of a GTP/ GDP...

this pathway results in the attachment of a small polypeptide through an isopeptide bond between modifying enzyme and the ε-amino group of a lysine residue...

LN (January 1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". The...

produced polypeptides in aqueous solution include split inteins, spontaneous isopeptide bond formation and sortase ligation. In order to optimize synthesis of...

to adhere to human epithelial cells with the strength of a covalent, isopeptide bond (the same strength in which human body proteins are built). This...

Tussie-Luna MI, Michel B, Hakre S, Roy AL (2003). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor...

matrix protein from Clostridium perfringens that forms intermolecular isopeptide bonds". bioRxiv 10.1101/2024.11.04.621531. Tůmová, Pavla; Voleman, Luboš;...

1016/0006-291X(78)91249-4. PMID 666810. Goldknopf IL, Busch H (March 1977). "Isopeptide linkage between nonhistone and histone 2A polypeptides of chromosomal...

summarized in two parts: an initial thioester formation, followed by isopeptide bond formation. Fig. 1 Mechanism for Protein Serotonylation Serotonylation...

threonines residues are sensitive to hydroxylamine, but those bound to lysine (isopeptide bond) are resistant. In biological nitrification, the oxidation of NH3...

with other proteins can also be created genetically or by spontaneous isopeptide bond formation. A site for site-specific conjugation is facilitated by...

protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200...

Suga S, Nakanishi S, Imura H (Jul 1991). "Molecular cloning of a non-isopeptide-selective human endothelin receptor". Biochemical and Biophysical Research...

ubiquitination, urmylation requires a thioester intermediate and forms isopeptide bonds between Urm1 and its substrates. Moreover, the urmylation process...

asparagine. The ubiquitin is linked to the polypeptide molecule by an isopeptide bond between the carboxyl group (COO−) of ubiquitin's last glycine and...

cis splicing, via spliceosome snoRNA splicing protein ubiquitination isopeptide cross-linking via N6-glycyl-L-lysine negative regulation of chemokine-mediated...

of two active A units) crosslinks fibrins within the clot by forming isopeptide bonds between various glutamines and lysines of the fibrins. These bonds...

catalyse the formation of an intermolecular epsilon-(gamma-glutamyl)lysine isopeptide bond. Schalkwijk J, Wiedow O, Hirose S (June 1999). "The trappin gene...

summarized in two parts: an initial thioester formation, followed by isopeptide bond formation. Fig. 1 Mechanism for Protein Dopaminylation Dopaminylation...

(January 2016). "Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization". Scientific Reports. 6 19234. Bibcode:2016NatSR...

RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein". J. Biol...

shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds". Proceedings of the National Academy of Sciences...

mechanism is that the ester-linked ubiquitin chains limit the size of isopeptide-linked (K63 and/or M1) ubiquitin chains. A family quartet was found with...

Fujita T, Ozaki T, et al. (2004). "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1". J. Biol...

summarized in two parts: an initial thioester formation, followed by isopeptide bond formation. Fig. 1 Mechanism for Protein Histaminylation Monoaminylation...

family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases". J. Biol. Chem. 282 (41): 29729–29737. doi:10.1074/jbc.M704558200...

Streptavidins of higher valency has been obtained by utilizing the chemistry of isopeptide bond conjugation using the SpyTag/SpyCatcher technology. This involves...

summarized in two parts: an initial thioester formation, followed by isopeptide bond formation. Fig. 1 Mechanism for Protein Monoaminylation Monoaminylation...

protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–7...

dedicated peptidase. After the cleavage, a lasso cyclase enzyme forms an isopeptide bond between the N-terminal amine of the first amino acid of the peptide...

summarized in two parts: an initial thioester formation, followed by isopeptide bond formation. Fig. 1 Mechanism for Histone Monoaminylation Monoaminylation...

summarized in two parts: an initial thioester formation, followed by isopeptide bond formation. Fig. 1 Mechanism for Histone Dopaminylation Dopaminylation...

protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200...

LN (January 1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". The...

Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J...

rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation". The Journal of Investigative Dermatology. 104 (2): 204–10...

Cross-linking by transglutaminase (TGase) enzymes results in the formation of an isopeptide bond between peptide-bound glutamine and lysine residues and provide insolubility...

Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J...

Iwanaga S (1991). "Direct virus inactivation of tachyplesin I and its isopeptides from horseshoe crab hemocytes". Chemotherapy. 37 (5): 327–34. doi:10...

MI, Michel B, Hakre S, Roy AL (Nov 2002). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor...

a polar residue of another protein (usually a lysine) via a covalent isopeptide bond. This effectively tags the second protein, making it distinguishable...

rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation". The Journal of Investigative Dermatology. 104 (2): 204–10...

catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved...

Katsutoshi; Masaki, Tomoh (1990). "Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor". Nature. 348 (6303): 732–735...

RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein". The Journal...

Spectroscopic and Theoretical Analysis of a Spontaneously Formed Lys–Asp Isopeptide Bond". Angewandte Chemie International Edition. 49 (45): 8421–8425. doi:10...

Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J...

protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200...

Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J...

protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–7...

MI, Michel B, Hakre S, Roy AL (Nov 2002). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor...

domains function as deubiquitinating enzymes (DUBs) that can cleave the isopeptide bond found in ubiquitin chains. They are also "deISGylating" enzymes that...

papain-like proteases, including those of coronaviruses, can also cleave isopeptide bonds and can function as deubiquitinases. In animals, especially in mammalian...

5-diketopiperazines, being derived from the cyclisation of a dipeptide. Cyclic isopeptides contain at least one non-alpha amide linkage, such as a linkage between...

Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J...

endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes". Proc. Natl. Acad. Sci. U.S.A. 86...

found, including a phosphotyrosine, phosphoserine, and glycyl-lysine isopeptide. A portion of the 3' UTR of C1orf123 has 100% identity with the mRNA for...

endothelins (ETs), they form a homogenous family of strong vasoconstrictor isopeptides. Among them, a few slightly different substances can be named as SRTX-a...

protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–7...

Aoki M, Nakagawara A (March 2004). "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1". The...

transglutaminase are between n^ε-(γ-glutamyl)lysine residues which develop into isopeptide protein-protein linkages that adds to the stabilization of the cornified...

Schulman BA, McIntosh LP (2005). "Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1". J. Biol. Chem. 279 (47): 49131–7. doi:10.1074/jbc...

Tussie-Luna MI, Michel B, Hakre S, Roy AL (2003). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor...

Adélaïde J, et al. (2003). "Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH". J. Biol. Chem. 277...

LN (January 1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". The...

covalent bonds. In the case of EHD3, there are two cross-links which are isopeptide bonds between a lysine and a glycine. They are located in the 315th and...

of the modification sites by tandem mass spectrometry analysis of the isopeptides". J. Biol. Chem. 279 (38): 39653–62. doi:10.1074/jbc.M405637200. PMID 15272016...

rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation". J. Invest. Dermatol. 104 (2): 204–10. doi:10.1111/1523-1747...

of the modification sites by tandem mass spectrometry analysis of the isopeptides". The Journal of Biological Chemistry. 279 (38): 39653–39662. doi:10...