DTX2

DTX2
Identifiers
AliasesDTX2, RNF58, deltex 2, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 2
External IDsOMIM: 613141; MGI: 1921448; GeneCards: DTX2
Available structures
PDBOrtholog search: PDBe RCSB
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.3.2.27↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

113878

74198

Ensembl

ENSG00000282379
ENSG00000091073

ENSMUSG00000004947

UniProt

Q86UW9

Q8R3P2

RefSeq (mRNA)

NM_001102594
NM_001102595
NM_001102596
NM_020892

NM_001256096
NM_001256097
NM_001256098
NM_023742

RefSeq (protein)

NP_001096064
NP_001096065
NP_001096066
NP_065943

NP_001243025
NP_001243026
NP_001243027
NP_076231

Location (UCSC)Chr 7: 76.46 – 76.51 MbChr 5: 136.02 – 136.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.[5]

DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A.[6]

References

  1. ^ a b c ENSG00000091073 GRCh38: Ensembl release 89: ENSG00000282379, ENSG00000091073 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004947 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: DTX2 deltex homolog 2 (Drosophila)".
  6. ^ Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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