KCND2

KCND2
Identifiers
Aliases	KCND2, KV4.2, RK5, potassium voltage-gated channel subfamily D member 2
External IDs	OMIM: 605410; MGI: 102663; HomoloGene: 40828; GeneCards: KCND2; OMA:KCND2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	120,750,337 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	21,729,804 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; paraflocculus of cerebellum; ; lateral nuclear group of thalamus; ; pons; ; stromal cell of endometrium; ; right hemisphere of cerebellum; ; Brodmann area 23; ; prefrontal cortex; ; primary visual cortex; ; ganglionic eminence;
	Top expressed in
	lobe of cerebellum; ; habenula; ; cerebellar vermis; ; toe; ; medial geniculate nucleus; ; medial dorsal nucleus; ; third toe; ; olfactory tubercle; ; nucleus accumbens; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	potassium channel activity; metal ion binding; voltage-gated ion channel activity; ion channel activity; protein binding; A-type (transient outward) potassium channel activity; voltage-gated potassium channel activity; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; perikaryon; postsynaptic membrane; cell projection; membrane; plasma membrane raft; intrinsic component of plasma membrane; voltage-gated potassium channel complex; plasma membrane; dendritic spine; synapse; integral component of plasma membrane; neuronal cell body membrane; cell junction; neuronal cell body; dendrite; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic membrane; integral component of postsynaptic specialization membrane; postsynaptic density;
Biological process	chemical synaptic transmission; regulation of ion transmembrane transport; ion transport; potassium ion transport; transmembrane transport; potassium ion transmembrane transport; action potential; sensory perception of pain; protein homooligomerization; cellular response to hypoxia; neuronal action potential; locomotor rhythm; regulation of postsynaptic membrane potential; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	3751
	16508
	ENSG00000184408
	ENSMUSG00000060882
	Q9NZV8
	Q9Z0V2
	NM_012281
	NM_019697
	NP_036413
	NP_062671
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily D member 2 is a protein that in humans is encoded by the KCND2 gene.^[5]^[6]^[7] It contributes to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.^[8]

Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.^[7]

Interactions

KCND2 has been shown to interact with FLNC.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184408 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060882 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhu XR, Wulf A, Schwarz M, Isbrandt D, Pongs O (December 1999). "Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current". Receptors Channels. 6 (5): 387–400. PMID 10551270.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b "Entrez Gene: KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2".
^ Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–872. doi:10.1006/jmcc.2001.1376. PMID 11343410. S2CID 829154.
^ Petrecca, K; Miller D M; Shrier A (December 2000). "Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin". J. Neurosci. 20 (23): 8736–44. doi:10.1523/JNEUROSCI.20-23-08736.2000. PMC 6773047. PMID 11102480.