The Lowther baronetcy, of Marske in the County of York, was created in the Baronetage of England on 15 June 1697 for the 21-year-old William Lowther, subsequently Member of Parliament for Lancaster.^[2] His father was Anthony Lowther.^[3] He was the grandson of the London merchant Robert Lowther, brother of Sir John Lowther of Lowther Hall, the father of Sir John Lowther, 1st Baronet, of Lowther.^[4]

He was succeeded by his son, the 2nd Baronet, who also represented Lancaster in the House of Commons.^[3][5] On his death the title passed to his son, the 3rd Baronet, who served as Lord-Lieutenant of Westmorland. In 1755 he succeeded to the estates of his cousin Sir James Lowther, 4th Baronet, of Whitehaven;^[6] but then died unmarried, at an early age the following year when the baronetcy became extinct.

• Sir William Lowther, 1st Baronet (1670–1705)^[2]
• Sir Thomas Lowther, 2nd Baronet (died 1745)^[5][3]
• Sir William Lowther, 3rd Baronet (1727–1756)^[3][6]