MDPCP

MDPCP
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC18H25NO2
Molar mass287.403 g·mol−1
3D model (JSmol)
  • C1CCC(CC1)(N1CCCCC1)c1ccc2c(c1)OCO2
  • InChI=1S/C18H25NO2/c1-3-9-18(10-4-1,19-11-5-2-6-12-19)15-7-8-16-17(13-15)21-14-20-16/h7-8,13H,1-6,9-12,14H2
  • Key:ANUGFLCSICVCSB-UHFFFAOYSA-N

Methylenedioxyphencyclidine (3,4-MD-PCP, MDPCP) is a recreational designer drug with dissociative effects. It is an arylcyclohexylamine derivative, with similar effects to related drugs such as 3-MeO-PCP and 4-MeO-PCP.[1][2]

Chemical properties

MDPCP has the molecular formula C18H25NO2 and a molar mass of 287.403 g·mol−1. Its structural characteristics include a methylenedioxy functional group attached to the phenyl ring, a hallmark of several psychoactive substances within this category.

Pharmacology and effects

As a dissociative drug, MDPCP exerts its effects primarily through antagonism of the NMDA receptor, resulting in altered sensory perceptions and dissociative states. The drug's subjective effects are reported to be similar to those of related arylcyclohexylamine derivatives. It has been reported to have an affinity of 63 nM for NMDARs determined in rat forebrains and was reasonably selective over other receptors tested including monoamine transporters and opioid receptors.[3][2]

Given its status as a novel psychoactive substance, MDPCP may be subject to varying degrees of legal control across different jurisdictions, often falling under generic legislation targeting arylcyclohexylamine derivatives or dissociative substances.

See also

References

  1. ^ Wallach JV (2014). Structure activity relationship (SAR) studies of arylcycloalkylamines as N-methyl-D-aspartate receptor antagonists (Ph.D. thesis). University of the Sciences in Philadelphia. 3690548.
  2. ^ a b Wallach J, Brandt SD (2018). "Phencyclidine-Based New Psychoactive Substances". New Psychoactive Substances. Handbook of Experimental Pharmacology. Vol. 252. pp. 261–303. doi:10.1007/164_2018_124. ISBN 978-3-030-10560-0. PMID 30105474.
  3. ^ Wallach JV (2014). Structure activity relationship (SAR) studies of arylcycloalkylamines as N-methyl-D-aspartate receptor antagonists (Ph.D. thesis). University of the Sciences in Philadelphia. 3690548.

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