MM-77

MM-77
Clinical data
Drug classSerotonin 5-HT1A receptor antagonist
ATC code
  • None
Identifiers
  • 1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrrolidine-2,5-dione
CAS Number
PubChem CID
Chemical and physical data
FormulaC19H27N3O3
Molar mass345.443 g·mol−1
3D model (JSmol)
  • COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)CCC3=O
  • InChI=1S/C19H27N3O3/c1-25-17-7-3-2-6-16(17)21-14-12-20(13-15-21)10-4-5-11-22-18(23)8-9-19(22)24/h2-3,6-7H,4-5,8-15H2,1H3
  • Key:MQHOGPLXAXSQAJ-UHFFFAOYSA-N

MM-77 is a piperazine derivative which is a serotonergic drug, acting as a potent and selective 5-HT1A receptor antagonist. It is used for research into the 5-HT1A receptor and has anxiolytic effects in animal models.[1][2][3][4][5][6]

See also

References

  1. ^ Griebel G, Rodgers RJ, Perrault G, Sanger DJ (May 1999). "Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists". Psychopharmacology. 144 (2): 121–130. doi:10.1007/s002130050984. PMID 10394992.
  2. ^ Griebel G, Rodgers RJ, Perrault G, Sanger DJ (July 2000). "The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety". Neuropharmacology. 39 (10): 1848–1857. doi:10.1016/s0028-3908(00)00074-5. PMID 10884565.
  3. ^ Wesołowska A, Paluchowska M, Chojnacka-Wójcik E (June 2003). "Involvement of presynaptic 5-HT(1A) and benzodiazepine receptors in the anticonflict activity of 5-HT(1A) receptor antagonists". European Journal of Pharmacology. 471 (1): 27–34. doi:10.1016/s0014-2999(03)01814-4. PMID 12809949.
  4. ^ Bojarski AJ, Duszyńska B, Kołaczkowski M, Kowalski P, Kowalska T (December 2004). "The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands". Bioorganic & Medicinal Chemistry Letters. 14 (23): 5863–5866. doi:10.1016/j.bmcl.2004.09.029. PMID 15501057.
  5. ^ Alfredo BA, Ofir P (January 2005). "Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents". European Journal of Pharmacology. 508 (1–3): 155–158. doi:10.1016/j.ejphar.2004.12.013. PMID 15680266.
  6. ^ Briones-Aranda A, Castillo-Salazar M, Picazo O (March 2009). "Adrenalectomy modifies the hippocampal 5-HT(1A) receptors and the anxiolytic-like effect of 8-OH-DPAT in rats". Pharmacology, Biochemistry, and Behavior. 92 (1): 182–189. doi:10.1016/j.pbb.2008.11.008. PMID 19095004.
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