Route 224 passes through Cooks Brook and Chaswood, to Middle Musquodoboit, where it meets Route 357. The route turns left and runs through the northeastern part of the Musquodoboit Valley, passing through Centre Musquodoboit and Elmsvale. The route passes by the Musquodoboit Valley Provincial park in Middle Musquodoboit. In Upper Musquodoboit, the route meets Route 336 and turns south, where it begins to ascend the southern slope of the Musquodoboit Valley. The route then heads southeast toward the Eastern Shore, passing through Beaver Dam and Marinette then on to its eastern terminus in Sheet Harbour, for a distance of