The Pimlico Spring Handicap was a race for Thoroughbred horses run annually from 1917 through 1932 at Pimlico Race Course racetrack in Baltimore, Maryland. The mile and one-sixteenth race on dirt was open to horses of either sex age three and older.

For most of its duration, the event attracted top-level horses such as inaugural winner Pennant, the 1913 Belmont Futurity winner and sire of U.S. Racing Hall of Fame inductee, Equipoise.^[1] Others include 1918 winner Cudgel, who beat that year's American Champion Older Male Horse, Omar Khayyam.^[2] In 1921 Sandy Beal won the Pimlico Spring Handicap beating 1920 Kentucky Derby winner Paul Jones,^[3] and 1922 winner Exterminator had already won a Kentucky Derby and by the time he retired from racing had been named a five-time Champion as well as a U.S. Racing Hall of Fame inductee.^[4]

The Pimlico Spring Handicap was a victim of the Great Depression in the United States which brought much consolidation of races at every track and a dramatic reduction in purse money.^{[citation needed]}

Speed record: (at 1 1/16 miles)

• 1:45 0/0 - Edisto (1926)

Most wins by a jockey:

• 2 - Fred Stevens (1924, 1930)

Most wins by a trainer:

• 2 - H. Guy Bedwell (1918, 1920)

Most wins by an owner:

• 2 - Harry Payne Whitney (1917, 1923)
• 2 - J. K. L. Ross (1918, 1920)