RNA family
Small Cajal body specific RNA 15 (also known as SCARNA15 or ACA45 ) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine ) of U1 spliceosomal RNA .
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1 , U2 , U4 , U5 and U12 .[ 1]
ACA45 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1.[ 2] [ 3]
It has been shown that human ACA45 can be processed into a 21 nucleotides long mature miRNA by the RNAse III family endoribonuclease dicer .[ 4] [ 5] endoribonuclease drosha .[ 6]
References
^ Darzacq X, Jády BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (June 2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs" . The EMBO Journal . 21 (11): 2746– 56. doi :10.1093/emboj/21.11.2746 . PMC 126017 PMID 12032087 . ^ Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery" . Molecular and Cellular Biology . 24 (13): 5797– 807. doi :10.1128/MCB.24.13.5797-5807.2004 . PMC 480876 PMID 15199136 . ^ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs" . Nucleic Acids Research . 34 (Database issue): D158-62. CiteSeerX 10.1.1.105.7552 doi :10.1093/nar/gkj002 . PMC 1347365 PMID 16381836 . ^ Ender C, Krek A, Friedländer MR, Beitzinger M, Weinmann L, Chen W, Pfeffer S, Rajewsky N, Meister G (November 2008). "A human snoRNA with microRNA-like functions" . Molecular Cell . 32 (4): 519– 28. doi :10.1016/j.molcel.2008.10.017 PMID 19026782 . ^ "mmu-miR-1839" . MiRBase .^ Babiarz JE, Ruby JG, Wang Y, Bartel DP, Blelloch R (October 2008). "Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs" . Genes & Development . 22 (20): 2773– 85. doi :10.1101/gad.1705308 . PMC 2569885 PMID 18923076 .
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