In 1985, Sher became director of development at Hill/Obst Productions. In 1987, she became Vice President of Production and in 1991, she became Senior Vice President at Lynda Obst Productions.[3] She went on to work with Danny DeVito and Michael Shamberg at Jersey Films, and now operates Double Feature Films with Michael Shamberg, with whom she co-founded the company. Some of the movies that Sher has worked on as a producer include Django Unchained, the Hateful Eight, and Pulp Fiction. Sher also worked on the 2005 Independent Spirit Award-winning Garden State, and three films with director Steven Soderbergh: Contagion, Erin Brockovich, and Out of Sight. Additional credits include Oliver Stone's World Trade Center, Matilda, and Along Came Polly. Her production company is Shiny Penny Productions.[4]
Sher dated director Quentin Tarantino, but their relationship ended during the development of Pulp Fiction, on which Sher was a producer.[5]
In 2015, Sher was named co-president of Activision Blizzard Studios.[6][7][8] which is devoted to creating television and films based on the company's library of intellectual properties, including Activision Publishing Call of Duty and Skylanders. In June 2021, Sher signed an overall deal with FX Productions.[9]