ARTIKELDIGITAL.COM

transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the STAT protein family. STAT3 is a member...

STAT3 gain-of function (GOF) is a rare genetic disorder of the immune system, leading to early-onset autoimmunity and a variety of multi-organ disorders...

phosphate groups to) proteins. There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many different domains...

which acts as a proteolysis targeting chimera (PROTAC) against the protein STAT3, acting by targeting this protein for destruction by cell maintenance enzymes...

between PI3K and JAK in Stat3 phosphorylation is that PI3K phosphorylates Stat3 on the S727 residue whereas JAK phosphorylates Stat3 on the Y705 residue....

nucleus. STAT3 regulates several genes in response to growth factors and cytokines and play an important role in cell growth. Therefore, STAT3 facilitates...

activity, nifuroxazide has been predicted to possess properties of inhibiting STAT3, so it can potentially interfere with a specific cell signaling pathway...

STAT3 (pSTAT3), found in 50% of lung adenocarcinomas, and IL-6. Further investigation revealed that mutant EGFR could activate the oncogenic STAT3 pathway...

impetiginosus, that acts as an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer, acting as a stemness...

National Medical Center in Duarte, California. His research has shown that the STAT3 protein plays a role in protecting cancers from immune responses and contributes...

receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor...

mammalian STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are involved...

dominant or autosomal recessive. Many patients with autosomal dominant STAT3 hyper-IgE syndrome have characteristic facial and dental abnormalities,...

The STAT3-Ser/Hes3 signaling axis is a specific type of intracellular signaling pathway that regulates several fundamental properties of cells. Cells...

bupropion anti-inflammatory action: involvement of the TLR2/TLR4 and JAK2/STAT3". Inflammopharmacology. 29 (4): 1101–1109. doi:10.1007/s10787-021-00829-4...

is a drug that acts as an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer and autoimmune...

UC-514321 is an experimental drug which acts as an inhibitor of the proteins STAT3 and STAT5. This blocks the transcription of the enzyme Tet methylcytosine...

turn, inhibits proliferation. Rex1 was also found to inhibit NOTCH and STAT3, two transcription factors which lead to differentiation. Therefore, Rex1...

molecule JAK2 (Janus kinase) inhibitor, with additional minor inhibition of STAT3. In phase I trial, 16% of patients receiving the drug developed tumor lysis...

Anatabine has anti-inflammatory activity partly through inhibition of STAT3 phosphorylation in vitro and in vivo. On a biochemical level, it appears...

to inhibit STAT. For example, PIAS1 inhibited STAT1, and PIAS3 inhibited STAT3. When it was discovered that PIAS proteins did far more than simply inhibit...

arm of chromosome 17. The phenotype may be associated with variation in STAT3 or ORMDL3 genes. Marla J. F. O'Neill (11 January 2022). "INFLAMMATORY BOWEL...

expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha". Blood....

06.010. PMID 16210110. Wu R, Sun S, Steinberg BM (2003). "Requirement of STAT3 activation for differentiation of mucosal stratified squamous epithelium"...

with a dissociation constant (KD) of 7.1 pM and inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5...

Th17 cells are signal transducer and the activator of transcription 3 (Stat3) and retinoic acid receptor-related orphan receptors gamma (RORγ) and alpha...

apoptosis and cell cycle arrest in lung squamous cancer cells suppresses STAT3 activation has antiinflammatory effects by inhibiting chemokine production...

STAT3 locus, directly regulates STAT3 expression, a key driver of temozolomide (TMZ) resistance in glioblastoma. Silencing TMZR1-eRNA reduced STAT3 mRNA...

molecule inhibitors of JAK3 (e.g. tofacitinib), JAK1/JAK2 (e.g. AZD1480), STAT3 (e.g. WP1066), and DDX3X (e.g. RK-33) are being study in pre-clinical in...

dependent on IL-6 amplifier activation, which is dependent on NF-κB and STAT3 activation. This research provides evidence for a critical role for CCL20...

hyperactivated STAT3 proteins in their bone cells. Cortical bone maturation depends on SOCS3-mediated suppression of interleukin-6 cytokine-induced STAT3 phosphorylation...

IL-10RA IL-10RB Stat3, Stat1, Stat5 IL-19/20/24 IL-20RA IL-20RB Stat3, Stat5 IL-20/24 IL-22R IL-20RB Stat3, Stat5 IL-22 IL-22R IL-10RB Stat3, Stat1, Stat5...

et al. (2005). "STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation"...

shown to induce autophagy in hepatocellular carcinomas by inhibiting JAK2/STAT3 pathways, which may present possibilities of anti cancer mechanism in bufothionine...

production. In the absence of SOCS3, IL-23-induced STAT3 phosphorylation is enhanced, and phosphorylated STAT3 binds to the promoter regions of both IL-17A...

may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1 expression has been linked to...

factor for primary astrocytes and its expression is controlled by NFI-X3, STAT3, and AP-1. CHI3l1 is induced by a variety of cancers and in the presence...

phosphorylated STAT3 in Interleukin -6 (IL-6) activated murine myeloblast M1 cells. This interaction is mediated via PIAS3 binding to the STAT3 DNA binding...

α-Pyrrolidinooctanophenone promotes activation of human microglial cells via a ROS/STAT3-dependent pathway. α-Pyrrolidinooctanophenone was metabolized into hydroxy-derivatives...

portions of the α subunit. This recruits STAT3, which is additionally phosphorylated by JAK1 and TYK2. STAT3 homodimerizes, moves to the cellular nucleus...

Michael reaction. This inhibits the phosphorylation of STAT3 and increases the S-glutathionylation of STAT3 and therefore deactivating it. This leads to an increase...

factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. STAT proteins are key activators of gene...

transcription factor called signal transducer and activator of transcription 3 (STAT3). The SAFE pathway interacts with the reperfusion injury salvage kinase...

receptor-α, capable of stimulating cell proliferation through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the hematopoietic...

(September 2009). "New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain"...

lines BEL-7402 and HepG2 Cucurbitacin can also inhibit VEGFR2-mediated Jak-STAT3 and MAPK signaling pathways. Anti-angiogenesis property of cucurbitacin...

(causing autoimmune polyglandular syndrome), FoxP3 (causing IPEX syndrome), or STAT3 include type 1 diabetes in their effects. There is ongoing research for...

of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-κB pathways and promotes cell survival in human cancer cells". Cancer...

liver disease, Parkinson's disease, prostate cancer, Stargardt disease, STAT3-expressing cancers, Usher syndrome. Several ASOs are currently being investigated...

inhibits the proliferation of various cancer cell types by inhibiting the STAT3 activation pathway, and may also decrease proliferation of cancer cells...

multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene...

rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways". Phytochemistry. 194. doi:10.1016/j.phytochem.2021.113018...

3 (STAT3) inhibitor to induce apoptotic cell death and decrease DU-145 cancer cell proliferation. DU-145 cells consistently express activated STAT3 and...

interact with: ELP2, GNB2L1 IL6ST, Grb2, IL2RB, IRS1, IL10RA, PTPN11, STAM2, STAT3, STAT5A, STAT5B, and TNFRSF1A. Janus kinase inhibitor GRCh38: Ensembl release...

included chronic granulomatous disease, Job's syndrome (autosomal dominant STAT3 deficiency) and the genetic conditions predisposing people to mycobacterial...

and capsular invasion. Overexpression of AGK sustains constitutive JAK2/STAT3 activation, consequently promoting the cancer stem cell population and augmenting...

the transcription factor STAT3 binds to IL20RA and STAT3 becomes activated.[1] IL20RA has multiple docking sites for STAT3. Research indicates that IL20RA...

STAT3 – Embryonic lethal, increased histone acetylation, increase in p21 and p27 HDAC2 1 Nucleus Ubiquitous Glucocorticoid receptor, YY1, BCL6, STAT3...

degradation product of GnRH. GnRH-(1-5) was found to induce STAT3 phosphorylation (pSTAT3) in GN11 cells. GnRH-(1-5) was not found to affect cAMP levels...

developing cancer. An example of this is the overactivation of the IL-6/STAT3 pathway, which has been linked to colitis-associated cancer. Basal lamina...

unknown mechanism of protein stabilisation and transcriptional regulation of Stat3. Other pathways influenced by Bcl3 activity include phosphorylation of AKT...

hypereosinophilia or eosinophilia due to mutations in any one of the following genes: STAT3, DOCK8, PGM3, SPINK5, and TYK2 (see mutations in the hymperimmoglobulin...

kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism". Blood. 127 (17): 2144–54. doi:10.1182/blood-2015-10-678706...

Many cases of AML-M5 are seen to have enhanced phosphorylation of the STAT3 protein due to increased induction of cytokines thus increasing cell proliferation...

patients with CD4+ T-cell disease carried a STAT3-JAK2 fusion gene. This gene consists of a fusion between the STAT3 gene at position 2.2 on the long (or "g")...

EIF4EBP1, FKBP1A, GPHN, KIAA1303, PRKCD, RHEB, RICTOR, RPS6KB1, STAT1, STAT3, Two-pore channels: TPCN1; TPCN2, and UBQLN1. GRCh38: Ensembl release 89:...

1126/science.1684878. PMID 1684878. "STAT3 - Signal transducer and activator of transcription 3 - Homo sapiens (Human) - STAT3 gene & protein". www.uniprot.org...

and IL-10 CD4 T cells. The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs. IL-10 from CD4 T cells activate NK cells' ADCC to apoptose...

Blatt L, Croze E, Mullersman JE, Pfeffer LM (1996). "Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor". J. Biol...

cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle...

response. ANGPTL4 induces nitric oxide production through an integrin/JAK/STAT3-mediated upregulation of iNOS expression in wound epithelia, and enhances...

symptoms of DOCK8 deficiency are similar to the autosomal dominant form, STAT3 deficiency. However, in DOCK8 deficiency, there is no skeletal or connective...

, et al. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L...

breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways". Molecular Cancer. 16 (1): 57. doi:10...

manipulating AQP4 channels, diminishing the action of NF-kB, or regulating the STAT3 pathway in order to reduce the inflammatory effects of reactive astrocytes...

PKA-related gene (Pkare); protein kinase MysPDZ 110-kDa myosin XVIIIA STAT1, STAT3, STAT5 Signal transducers and activators of transcription-1, -2, -3; transcription...

humans is encoded by the TRIP10 gene. TRIP10 has been shown to interact with STAT3, Wiskott-Aldrich syndrome protein, Huntingtin, CDC42, AKAP9 and RHOQ. GRCh38:...

and phosphorylation. RIG-G has shown the capacity to inhibit NF-κB and STAT3 signaling in lung cancer cells, which demonstrates the potential of type...

Granulocytecolony stimulating factor (G-CSF) 2003 activator of transcription-3 (STAT3) in the periphery of the infarction 53 1 No effect - G-CSF did not improve...

cytotoxic T lymphocytes (CD8+/CTL), temporal response of Tregs, and the STAT3 signaling pathway. The role of the antitumor immune response in cancer therapeutics...

progression by blocking E-selectin expression in endothelial cells via STAT3". Cancer Letters. 510: 13–23. doi:10.1016/j.canlet.2021.04.005. hdl:2318/1791282...

Inhibition of ALK subsequently blocks cell signalling pathways, including STAT3 and the PI3K/AKT/mTOR pathway, and induces death (apoptosis) of tumour cells...

Nojiri S, Joh T, Miura Y, et al. (2004). "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3". Biochem. Biophys. Res. Commun. 314...

STAT1 and STAT3 transcription factors that bind specifically to the receptor subunits, IL-27ɑ and glycoprotein. IL-27 is able to activate STAT3 signaling...

DOK1, DOK5, GDNF family receptor alpha 1, GRB10, GRB7, Grb2, SHC1, and STAT3. GRCh38: Ensembl release 89: ENSG00000165731 – Ensembl, May 2017 GRCm38:...

deficiency MOPD1 deficiency EXTL3 deficiency Hyper IgE syndromes Job syndrome (STAT3 deficiency) Comel-Netherton syndrome PGM3 deficiency Hypohidrotic ectodermal...

that involves the phosphorylation of STAT3 on the serine residue and subsequent elevation of Hes3 expression (STAT3-Ser/Hes3 Signaling Axis) oppose neuronal...

particularly hyper-IgE syndromes. She has studied patients with STAT3-mutated Hyper-IgE syndrome (STAT3 DN; Job's syndrome), which involves eczema, recurrent infections...

the signal and phosphorylate STAT3 and STAT4. STATs dimerise and activate transcription of target genes in nucleus. STAT3 is responsible for key Th17 development...

IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3, which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule...

undifferentiated state. This is achieved through its activation of the Jak-STAT3 pathway, which has been shown to be necessary and sufficient towards maintaining...

through the activation of STAT3 signaling. ITGA1 inhibition decreases STAT3 expression, phosphorylated STAT3 activity, STAT3 nuclear localization, and...

ATF3, CREB1, HIF1α, JUN, KLF6, KLF7, MYC, SMAD1, SMAD2, SMAD3, SOX11, SRF, STAT3, TP53, and XBP1. Several of these can also boost the regenerative capacity...

anti-apoptotic genes prevents LLPCs from undergoing programmed cell death. STAT3 (Signal transducer and activator of transcription 3): LLPCs respond to interleukin...

"Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway". Journal of Immunology. 179...

PMID 22985997. Grivennikov SI, Karin M (February 2010). "Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer". Cytokine & Growth...

transcription 3 (STAT3). IRAK-1 forms a complex with STAT3 and the IL-10 promoter element in the nucleus and is required for STAT3 phosphorylation and...

complex D. melanogaster Endosomal protein sorting Bicoid mRNA localization STAT3 M. musculus Transcription factor Electron transport chain Histone H3 X....

humans is encoded by the ELP2 gene. ELP2 has been shown to interact with STAT3 and Janus kinase 1. GRCh38: Ensembl release 89: ENSG00000134759 – Ensembl...

activation STAT3 (Signal Transducer and Transcription 3), which seems to be a transcription factor in the expression of Ifi202. Ifi202 contains a STAT3 binding...

and involves the transcription factors C/EBP, NF-κB, AP2, SAF, Sp1 and STAT3. Elevation of the transcript of SAA1 is often seen in cDNA arrays used for...

interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the...

signalling which is linked with activation of the MAPK cascade, PI3K cascade and STAT3 activation. OSM induced recruitment of SHC to the OSMRβ sub-unit has been...

RNF14, RNF4, SART3, SIRT1, SMAD3, Small heterodimer partner, Src, SRY, STAT3, SVIL, Testicular receptor 2, Testicular receptor 4, TGFB1I1, TMF1, TRIM68...

0811902106. PMC 2626610. PMID 19144919. Katoh M, Katoh M (February 2007). "STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues...

Rashidi, Mohsen; Taheriazam, Afshin; Samarghandian, Saeed (August 2022). "STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy...

the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway". Journal of Genetics and Genomics. 51 (10): 1055–1065...

loop between IL-6, STAT3 and NFkB. Namely, when ARID1A and PIK3CA are mutated, there is a promotion of IL-6 and activation of STAT3 because of the newly...

IL-6-receptor, which is associated with activation of the transcription factor STAT3 (which binds to the binding site in the mIndy promoter) and thereby rise...

inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages...

Rho-associated kinase and Aurora kinase. STAT3. In 2003 the Sebti lab discovered JSI-124, a selective STAT3 signaling pathway inhibitor. Bcl/Mcl. The...

Kacper; Sauer, Natalia Julia; Karwacki, Jakub (2024-10-31). "Avelumab reduces STAT3 expression with effects on IL-17RA and CD15". Dental and Medical Problems...

its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. IL-20 has a broad range of functions and is involved...

as by SOCS proteins, which inhibit the JAK-STAT signal to regulate it. STAT3 is the main transcription factor activated with IL20R signaling. IL20R subunit...

NCOR1, NCOA1, NCOA2, NCOA3, POU2F1, RANBP9, RELA, SMAD3, SMARCD1, SMARCA4 STAT3, STAT5B, Thioredoxin, TRIM28, and YWHAH. Membrane glucocorticoid receptor...

identify STAT3, a protein that helps to protect tumor cells from the immune system. Her group is developing possible drug treatments using CpG-Stat3 siRNA...

regenerative species like the zebrafish or the axolotl. Here, activation of STAT3 by IL-11 is mandatory to allow regeneration and to prevent injury-induced...

implantation and this downregulation promotes trophoblast invasion by activating STAT3. Homeobox A10 has been shown to interact with PTPN6. Homeobox GRCh38: Ensembl...

damage-induced hair cell regeneration has been demonstrated in the inner ear. The Stat3/SOCS3 pathway has been identified as key in promoting hair cell regeneration...

necessary for the HGF-induced branching morphogenesis. MET activates the STAT3 transcription factor directly, through an SH2 domain. The beta-catenin pathway...

2001). "Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel...

LM, Lu P, Hugenholtz F, Belzer C, Stolte EH, et al. (March 2015). "IL-22-STAT3 pathway plays a key role in the maintenance of ileal homeostasis in mice...

oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130". Mol. Pharmacol. 63 (5): 1104–16. doi:10.1124/mol...

confirmed to interact with STAT3, such that ECHS1 specifically represses STAT3 activity by inhibiting STAT3 phosphorylation. STAT3 can act as both an oncogene...

including Wnt/β-catenin, epithelial-mesenchymal transition (EMT), notch, and STAT3. When overexpressed, it acts as a tumor suppressor gene in many cancer types...

breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways". Molecular Cancer. 16 (1): 57. doi:10...

Loughran TP Jr, Heckman CA, Maciejewski JP, Mustjoki S (2012). "Somatic STAT3 mutations in large granular lymphocytic leukemia". New England Journal of...

heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3". Biochemical and Biophysical Research Communications. 300 (4): 847–52....

differentiation, neutrophil function, and inflammasome regulation, including STAT3-associated hyper-IgE syndrome, STAT1 gain-of-function disease, chronic granulomatous...

Priel-Halachmi S, Ben-Dor I, Shpungin S, et al. (2000). "FER kinase activation of Stat3 is determined by the N-terminal sequence". J. Biol. Chem. 275 (37): 28902–10...

AR, GR, E2F and STAT3. PELP1 participates in activation of ESR1 extra-nuclear actions by coupling ESR1 with Src kinase PI3K STAT3 ILK1 and mTOR PELP1...

activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3". The Biochemical Journal. 370 (Pt 2): 391–6. doi:10.1042/BJ20021935. PMC 1223207...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

(2013), Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock. Mol Mod Rep 7(4): 1293-1299. Cao Y, Shan...

interact with: ARNTL, ARNT, CREBB, EP300, HIF1AN, Mdm2, NR4A, P53, PSMA7, STAT3, UBC, VH and VHL. GR (NR3C1). On an organismal level, when a fish is introduced...

The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)...

metabolic function. It appears to activate oncogenic pathways, such as STAT3 and enzymes like MMP2 and MMP9, which contribute to enhanced cell proliferation...

transcription control. There are some signaling pathways, such as LIF/JAK/STAT3 (Leukemia inhibitory factor/Janus kinase/Signal transducer and activator...

Reprimo[citation needed] RPA1, RPL11, S100B, SUMO1, SMARCA4, SMARCB1, SMN1, STAT3, TBP, TFAP2A, TFDP1, TIGAR, TOP1, TOP2A, TP53BP1, TP53BP2, TOP2B, TP53INP1...

he also discovered. He identified the transcription factors NF-IL-6 and STAT3, both central to the action of IL-6. He further discovered a family of suppressors...

(December 2014). "Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity". Sci Rep. 4: 7330. Bibcode:2014NatSR...

(2001). "Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma". Am. J. Pathol. 158 (1): 25–32. doi:10...

tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell". International Journal of Cancer. 129 (10):...

gene Gfap is repressed during early neurogenesis due to methylation of its STAT3 binding sites. Research published in 2001 demonstrated that DNMT3a maintains...

FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution". Dev Biol. 333 (2): 238–50. doi:10...

pathways involved in neural repair. He discovered that the PTEN/mTOR and SOCS3/STAT3 signaling pathways are key regulators of the intrinsic growth capabilities...

factor c/EBP regulates development of MDSCs in bone marrow and in tumors. STAT3 also promotes development of MDSCs, whereas IRF8 could counteract MDSC-inducing...

that involves the phosphorylation of STAT3 on the serine residue and subsequent Hes3 expression increase (STAT3-Ser/Hes3 Signaling Axis). Odelberg S....

Z, Darnell JE (1995). "Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation". Cell. 82 (2): 241–50...

cancer-associated fibroblasts which communicate with tumour cells via IL-6/STAT3 and this regulates cancer stem cell maintenance via Snail. Esg is expressed...

suppressing hepatocellular carcinoma growth and metastasis, by decreasing Stat3 and Akt signalling activity beside Notch1 inhibition. Concomitant administration...

proximal enhancer Specification markers Absent Fgf5, T Response to Lif/Stat3 Self-renewal None Response to Fgf/Erk Differentiation Self-renewal Clonogenicity...

for both genes; and/or activating mutations in JAK1 (75% of cases) and STAT3 (25% of cases). In Type II RCD, the same types of abnormal ILE found in...

hypothalamic nuclei. Once leptin has bound to the Ob-Rb receptor, it activates the stat3, which is phosphorylated and travels to the nucleus to effect changes in...

complex, JAK kinases are activated which phosphorylate and activate STAT1, STAT3, and STAT5. The OSMR portion of the IL-31 binding complex contains intracellular...

causing a rare form of autosomal recessive Hyper IgM syndrome, and on STAT3, the gene causing autosomal dominant Hyper IgE syndrome if mutated. In 1995...

PTPN1, PTPN11, PTPN6, PTPRK, SH2D3A, SH3KBP1, SHC1, SOS1, Src, STAT1, STAT3, STAT5A, UBC, and WAS, PAR2. In fruitflies, the epidermal growth factor...

expression of hTERT via signal transducer and activation of transcription 3 (STAT3), proposing a mechanism for increased cancer incidence in obese individuals...

ENSG00000170581 STAT Known motif – In vivo/Misc source [886] TNRGTTTCDNTTYC STAT3 ENSG00000168610 STAT Known motif – In vivo/Misc source [887] HTTCCYRKMA...

response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element;...

H, Chung J, Kao HY, Yang YC (March 2003). "Tip60 is a co-repressor for STAT3". The Journal of Biological Chemistry. 278 (13): 11197–11204. doi:10.1074/jbc...

the region more open and accessible for transcription. Acetylated p53 and STAT3 have been shown to bind to CBP's bromodomain. The 380 protein residue lysine...

progression and mitosis, and it also modulates the transcription factors SRF, STAT3, and NFkB. It has been hypothesized that targeting Cdc42 in conjunction...

anti-viral activities. Sugiol has been shown to inhibit the oncogenic protein STAT3, which is constituently on in malignant tumors. Sugiol directly inhibits...

than the γ chain. of the TCR. Current evidence suggests that patients with STAT3 mutations are more likely to respond to methotrexate therapy. First-line...

AM, Katseff AS, Ratliff TS, Garza LA (February 2016). "Interleukin 6 and STAT3 regulate p63 isoform expression in keratinocytes during regeneration". Experimental...

BTF3 increases EMT and metastatic potential by increasing the JAK2 or STAT3 signaling pathways. Having FOXM1, eliminates several of these cancer-related...

PCAF, PPARGC1A, Peroxisome proliferator-activated receptor alpha, SNW1, STAT3, STAT6, TRIP4, and Thyroid hormone receptor beta. GRCh38: Ensembl release...

transcription 3 (Stat3). Stat3 is recruited to the activated LIF receptor and phosphorylated by Janus kinase. It bears noting that LIF and Stat3 are not sufficient...

cell growth and increases LAM cell viability. Upregulation of STAT1 and STAT3 and autophagy are known mediators of LAM cell viability and survival. LAM...

transcriptional inhibitor that acts by inhibiting STAT3's DNA binding activity. PIAS3 directly interacts with MITF, and STAT3 does not interfere with the interaction...

(January 2002). "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth & Differentiation...

dephosphorylates STAT3, signal transducer and activator of transcription 3, on tyrosine 705, a residue that is critical for the activation of STAT3. Dephosphorylation...

(November 2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". The EMBO Journal. 19 (21): 5845–5855...

S (2012). "GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer". PLOS ONE. 7 (10) e46410. Bibcode:2012PLoSO...746410L...

Lin, L.; Wu, C.; Xu, S.; Jiang, Z.; Xu, J.; Liu, Q.; Cao, X. (2014). "The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation"...

dendritic cells and overexpression of CTLA-4. IL-6 mediates activation of STAT3 transcription factor which is critical for proliferation of cancer cells...

(2009). "Green tea catechins inhibit angiogenesis through suppression of STAT3 activation". Breast Cancer Research and Treatment. 117 (3): 505–515. doi:10...

dysfunction-associated steatohepatitis (MASH, formerly NASH) through AGE-RAGE and JAK1-STAT3 signalling pathways. Comprehensive anti-inflammatory activity has been documented...

mediated by an increase in δ-secretase levels, via an upregulation of the JAK2/STAT3 pathway and C/EBPβ downstream of TrkB. Additionally, TrkB has been shown...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

"Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)". Proc. Natl. Acad. Sci. U.S.A. 101 (1): 99–104. Bibcode:2004PNAS...

responsible for induction of angiotensinogen synthesis in liver through JAK/STAT3 pathway, which gets activated through high affinity membrane protein receptors...

Kuang Y, Zhao X, Li G, et al. (June 2014). "A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma". Journal of Experimental...

kinases (JAKs), and the signal transducer and activator of transcription 3 (STAT3) to initiate the molecular signaling cascade shown on the diagram on the...

S2CID 7713780. Klosek SK, Nakashiro K, Hara S, Goda H, Hamakawa H (October 2008). "Stat3 as a molecular target in RNA interference-based treatment of oral squamous...

Nociti V, Iorio R, et al. (Dec 2008). "The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early...

termination, and also highlighted the significance of PTPRD in deactivating STAT3 and Rsu-1 as a Ras signaling suppressor gene with deletions in some HCC...

Some suggested therapeutic targets include the PI3K/AKT/mTOR, VEGF, Il-6/STAT3, MET, and HNF-1beta pathways. Better insight into genomic heterogeneity...

pathway or through reactive oxygen species (ROS)-mediated activation of the STAT3 pathway. Downstream effects of this include regulation of gene expression...

pathways, including Akt, signal transducer and activator of transcription 3 (STAT3), mitogen-activated protein kinase, Ras, and Wnt signaling. Activated Twist...

phosphorylation and activation of signal transducer and activator of transcription 3 (STAT3) and STAT5. Due to sharing of receptor subunits between IL-2 and IL-15,...

Exhibits multiple biological activities, including liver protection, inhibits STAT3 transcription factor activation, and disrupts the actin cytoskeleton of...

dapansutrile include several phosphorylated kinases such as Src; Fyn; HcK; STAT3. Human monocyte derived macrophages (HMDM) cells were stimulated with lipopolysaccharide...

and a conserved DNA binding domain similar to the transcription factor STAT3/dna complex or STAT1/dna complex suggests that it could act as a transcription...

different signal transducer and activator (STAT) proteins namely STAT1, STAT3 and STAT5 and thus connects this cytokine to various biological processes...

inhibits cell proliferation and induces apoptosis through activation of the STAT3 pathway in ovarian cancer1". All Life. 14 (1). Informa UK Limited: 646–656...

Q1 and SV40 T antigen. KPNA4 has been shown to interact with RECQL and STAT3. GRCh38: Ensembl release 89: ENSG00000186432 – Ensembl, May 2017 GRCm38:...

is not always clear. It (they) regulates signaling by: a) inhibiting the STAT3-Janus kinase pathway to block cellular pro-inflammatory responses; b) stimulating...

Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y (2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling". Nat. Cell Biol...

IL-1 to Th17 cells and IL-18 to Th1 lymphocytes. IL-1 combined with some STAT3 activators, such as IL-6, IL-21 or IL-23, which are important for Th17 lymphocytes...

interact with: Cyclin O, DNA-PKcs, Ku70, MEN1, RPA3, Replication protein A1, STAT3, TP53BP1 and Uracil-DNA glycosylase. Single-stranded binding protein Replication...

prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation". The Journal of Biological...

"CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2, and STAT3 pathway in colorectal cancer". Acta Biochimica et Biophysica Sinica. 51...

Sherry B, Metz CN (November 2009). "Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation". Am. J. Physiol., Cell...

PMC 125559. PMID 11500364. Chung J, Uchida E, Grammer TC, Blenis J (Nov 1997). "STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively...

brain development that regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation, suggesting a potential link between TMEM62 and neural signaling...

Liang ZP, Yang LH, Ma YP (2021). "Leonurine-Repressed miR-18a-5p/SOCS5/JAK2/STAT3 Axis Activity Disrupts CML malignancy". Frontiers in Pharmacology. 12 657724...

These genes regulate cell growth and survival. Other genes (e.g. JAK3, STAT3, and STAT5B ) that are mutated in far lower percentages of cases also regulate...

cell often found in tumors—were present. The extract suppressed the IL-10/STAT3/PD-L1 signaling pathway, which normally helps tumors evade immune attack...

transactivation of signal-transducer and activator of transcription 3 (STAT3) target genes but not other STAT family members. The homologous protein...

increases global post-reperfusion oxidative stress, likely due to decreased STAT3 and Erk phosphorylation. In addition, it appears that hippocampal oxidative...

EBF2 (~330 basepairs downstream of transcriptional start), NR5A2, ZNF423, STAT3 (all found ~120 basepairs downstream of previous transcription factor mentioned)...

degradation. BBS17 was found to function in the regulation of LebRb activating Stat3 transcription factor in relation to leptin sensitivity. This system of leptin...

Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3". Cell. 115 (3): 281–292. doi:10.1016/S0092-8674(03)00847-X. PMID 14636556...

anti-inflammatory response. The IL-37/IL-18Rα/IL-1R8 complex activates the STAT3 signaling pathway, decreases NF-κB and AP-1 activation and reduces IFNγ...

Sergeants. 2 Stat. 696, Military Agents became Deputy Quartermasters. 2 Stat3 816. Storekeepers in the Ordnance Department became Ordnance Storekeepers...

immunodeficiency. O'Shea and colleagues at the NIH identified the role of Stat3 in regulating T cell cytokine production in Job's syndrome. More recently...

phosphorylate and activate both STAT1 and STAT3. gp130 preferentially activates STAT3 which it can do through four STAT3 activation consensus sequences YXXQ:...

of acute myeloid leukemia (AML) Described fusion partners include ETV6, STAT3 and FLI1. About 50% of fusions are out of frame and result in high expression...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription, STAT5. In macrophages, it has also been shown to signal via STAT3. The cytokine activates macrophages to inhibit fungal survival. It induces...

M. (2011-07-26). "Humanized Lewis-Y Specific Antibody Based Delivery of STAT3 siRNA". ACS Chemical Biology. 6 (9): 962–970. doi:10.1021/cb200176v. ISSN 1554-8929...

activation of STAT3. The high level of STAT3 was described in isolated CSCs from liver, bone, cervical and brain cancer. The inhibition of STAT3 results in...

promotes C2C12 myoblast differentiation in vitro via upregulation of Tid1 and STAT3 acetylation". PLOS ONE. 15 (12) e0244791. Bibcode:2020PLoSO..1544791T. doi:10...

cachectic mediator proteolysis inducing factor activates NF-kappaB and STAT3 in human Kupffer cells and monocytes". Int. J. Oncol. 27 (4): 1105–11. doi:10...

IL22R Production of defensins from epithelial cells. Activates STAT1 and STAT3 and increases production of acute phase proteins such as serum amyloid A...

cytokine receptor fragment. When bait and prey interact, TYK2 phosphorylates STAT3 docking sites on the prey chimera, which ultimately leads to activation...

IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling". Scientific Reports. 11 (1): 22469. Bibcode:2021NatSR..1122469M...

G.; Zhao, Y.; Pestell, R.G.; Albanese, C.; Darnell, J.E. Jr. (1999). "Stat3 as an oncogene". Cell. 98 (3): 295–303. doi:10.1016/s0092-8674(00)81959-5...

MEN1, NFKB2, NFKBIE, NOTCH1, Nuclear receptor coactivator 1, RELA, RELB, STAT3, STAT6, and TSC22D3. GRCh38: Ensembl release 89: ENSG00000109320 – Ensembl...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

activated dendritic cells, which serves to activate the transcription factor STAT3, is required in addition to TGF-β1 for the differentiation of Th17 cells...

transcription factors Sp1, KLF5, FOXO1, MEF2C, SRY, GATA-4, and HNF-6, HMG-B2, STAT3, the androgen and estrogen (α) receptors, GATA-2, GATA-3, MyoD, E2F(1-3)...

receptor acts through the Jak/STAT pathway, utilizing Jak1 and Jak3 and a STAT3 homodimer to activate its target genes. It has been shown that IL-21R knock-out...

Liuc, Liao; Yuanc, Chen; Xiao-Did, Huang; Xue-Feic, Tian (June 2020). "STAT3 Inhibition by Centipede Scolopendra Extract in Liver Cancer HepG2 Cells...

SOCS1; SOCS2; SOCS3; SOCS4; SOCS5; SOCS6; SOCS7 SRC; SRMS STAT1; STAT2; STAT3; STAT4; STAT5A; STAT5B; STAT6 SUPT6H; SYK TEC; TENC1; TNS; TNS1; TNS3; TNS4;...

PMID 12759240. Wu Y, Diab I, Zhang X, Izmailova ES, Zehner ZE (Jan 2004). "Stat3 enhances vimentin gene expression by binding to the antisilencer element...

Schlafen family: SLFN5, SLFN11, SLFN12, SLFN12L, SLFN13, SLFN14 STAT proteins: STAT3, STAT5A, STAT5B Tubulins: TUBD1, TUBG1, TUBG2 Ubiquitin-conjugating enzymes:...

IL-2/15Rβγ heterodimer induces JAK1 activation that subsequently phosphorylates STAT3 via the β chain and JAK3/STAT5 activation via its γ chain. Once tyrosine-phosphorylated...

Peptidylprolyl isomerase A has been shown to interact with: ITK, CD147, P53, STAT3, Cyclophilin TRIM5alpha GRCh38: Ensembl release 89: ENSG00000196262 – Ensembl...

it may have a role in cancer treatment (e.g., due to its inhibition of STAT3 signalling). Silibinin has a number of potential mechanisms that could benefit...

cellular senescence by complexing with BIS to chaperone protein folding of STAT3 and activate the signaling pathway. Also, 14-3-3ζ can negatively regulate...

Evans CP, Gao AC (February 2014). "Inhibition of constitutively active Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells"...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

contain binding sites for transcription factors RCOR1, MILLT1, SIN3A, NFIC, STAT3, JUNB, FOS, EGR1, PHB2, RUNX3, and SRF. Many of these transcription factors...

also known to interact with AP-1. NFI-X3 has been shown to interact with STAT3. In embryonic cells, Nfix has been shown to regulate intermediate progenitor...

effect on Th17 cells that comes from inhibiting the activation of STAT1 and STAT3 pathways, which are normally induced through gp130 receptor by IL-6 and...

erythropoiesis Stat1 Viable Human dwarfism and craniosynostosis syndromes Stat3 Lethal Tissue specific phenotypes Stat4 Viable defective IL-12-driven Th1...

Ruan J, et al. (2013-11-28). Afarinkia K (ed.). "Concerted suppression of STAT3 and GSK3β is involved in growth inhibition of non-small cell lung cancer...

(December 2000). "Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: lack of specificity of stat...

of Women". Hua Eleanor Yu and her group are studying the involvement of STAT3 with cancer cells and the immune system, and developing possible drug treatments...

gastric cancer proliferation due to the failure to inactivate ERK 1/2, STAT3 and PI3K/AKT pathways, which are involved in cell survival and tumour progression...

Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y (June 2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling". Nature Cell Biology...

"Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus". Scientific Reports. 7 (1): 353. Bibcode:2017NatSR...

localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels". Biochem. Biophys. Res. Commun. 360 (2): 333–8. doi:10.1016/j...

low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells, Hui Song, Renxiao Wang, Shaomeng Wang,...

tumour-promoting role of Th9 cells in hepatocellular carcinoma through CCL20 and STAT3 pathways". Clinical and Experimental Pharmacology and Physiology. 44 (2):...

promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways". Blood. 99 (8): 2637–2646. doi:10.1182/blood.V99.8.2637...

activation of STAT3, the suppressive effect of Tregs is decreased together with ST2 and Foxp3 expression. It looks, that GATA3 with presence of STAT3 has different...

positive inflammatory feedback loop that involves the joint role of the NF-κB, STAT3, AP-1, and TEAD transcription factors along with YAP/TAZ co-activators as...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

"Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway". Journal of Immunology. 179...

ID1, ID2, MDFI, MOS, Retinoblastoma protein, Retinoid X receptor alpha STAT3, and TCF3. GRCh38: Ensembl release 89: ENSG00000129152 – Ensembl, May 2017...

HSP90A induces inflammation through the activation of the NF-κB (RELA) and STAT3 transcription programs that include the pro-inflammatory cytokines IL-6...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

CTX III could induce apoptosis via concomitant inactivation of the JAK2, STAT3, PI3K, and Akt signaling pathways. In Colo205, human colorectal cancer cells...

lines, silencing of the SOCS-3 gene via methylation has been shown to cause STAT3 protein activation, which caused uncontrolled proliferation. Cancer cells...

avelumab. In normal tissue, feedback between transcription factors like STAT3 and NF-κB restricts the immune response to protect host tissue and limit...

inhibition of STAT3 signaling which reduces the regulation of innate and adaptive immunity. In addition, AMBRA1 is an essential component for STAT3 signaling...

proliferation of cancer cells by interfering with the activity of a protein called STAT3. Research into the compound has also shown that it can inhibit osteoclast...

with cancer-testis antigen reactivation and germ cell biology, including STAT3, SRY, Nanog, and CREM. Promoter sequence conservation is largely restricted...

mutations are commonly observed in peripheral T cell lymphomas (PTCL), while STAT3 and STAT5B mutations are unique to large granular lymphocytic (LGL) leukemia...

Li S, Li A, et al. (April 2023). "Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis". Investigative Ophthalmology &...

activity; Decreases YAP/TAZ function and cell proliferation Cucurbitacin I JAK/STAT3 inhibitor Dasatinib Tyrosine kinase inhibitor Fluvastatin Statin Pazopanib...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

(2016). "Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway". Oncotarget. 7 (20): 29507–19. doi:10.18632/oncotarget...

molecules that are inhibited by JNK activation include NFAT4, NFATC1 and STAT3. By activating and inhibiting other small molecules in this way, JNK activity...

intergenic non-protein coding RNA 346, p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript, LINC00346 External...

lymphoma-2(Bcl-2) and B-cell lymphoma-extra large (Bcl-xl) through activating the STAT3(Signal transducer and activator of transcription) signal pathway, thus inhibiting...

"Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)". Proc. Natl. Acad. Sci. U.S.A. 101 (1): 99–104. Bibcode:2004PNAS...

Yoshimura A (2003). "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif". J. Biol. Chem...

constitutively with Janus kinase 2 (JAK2) and also binds to transcription activator STAT3 in a ligand-dependent manner. Three variants in the IL23R gene have been...

Th1 and Th2 CD4+ lineages and the differentiation of Th17 cells requires STAT3 and RORC. IL-17 receptor A (IL-17RA) was first isolated and cloned from...

IQGAP1, IQGAP2, Myd88, DMPK, NCKAP1, PAK1, PAK3, PARD6A, PARD6B, RICS STAT3, and TIAM1. GRCh38: Ensembl release 89: ENSG00000136238 – Ensembl, May 2017...

proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways". The Journal of Clinical Investigation. 114 (5): 643–51...

interact with the following signaling pathways: PI3K Akt IKK NFkB Caspase 9 STAT3 p38 MAPK VEGF IL-8 Shc Grb2/SOS Ras Raf MEK1 / MEK2 Erk1/2 FAK p190Rho/GAP...

mS100a7a15 recruits tumor-associated-macrophages (TAM) through RAGE and Stat3 activation to promote tumorigenesis. mS100a7a15 is upregulated in inflamed...

Ferraris P, et al. (2015). "IFN-λ Inhibits MiR-122 Transcription through a Stat3-HNF4α Inflammatory Feedback Loop in an IFN-α Resistant HCV Cell Culture...

Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, et al. (February 2003). "STAT3 signalling is required for leptin regulation of energy balance but not reproduction"...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

expression. MTA1 is a dual coregulatory as it stimulates the transcription of Stat3, breast cancer-amplified sequence 3, FosB, paired box gene 5, transglutaminase...

production in astrocytes and pathogenesis of EAE mice via targeting SOCS3/STAT3 signaling". Glia. 67 (1): 101–112. doi:10.1002/glia.23530. PMID 30294880...

also plays a role in cytokine-dependent signal transduction, including STAT3 signaling. PDIA3 may also participate in Vitamin D (specifically, calcitriol)...

factor MAFB. Expression is further regulated by GSK3 through activation of STAT3, which influences CD5L promoter activity. AIM belongs to the scavenger receptor...

JW, Poon LS, Chan AS, Yu FW, Lo RK, Wong YH (June 2010). "Activation of STAT3 by specific Galpha subunits and multiple Gbetagamma dimers". The International...

depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity". Nucleic...

in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling". Cancer Science. 96 (7): 425–433. doi:10.1111/j.1349-7006...

Retinoblastoma protein, Retinoic acid receptor alpha, SIN3A, SKI protein, STAT3, Serum response factor and Small ubiquitin-related modifier 1, Sp1 transcription...

024.421.200 – stat2 transcription factor MeSH D12.776.476.024.421.300 – stat3 transcription factor MeSH D12.776.476.024.421.400 – stat4 transcription...

occurring because selinexor causes a buildup of the transcription factor STAT3 in the nucleus of hematopoietic stem cells, preventing their differentiation...

regulated by the JAK/STAT pathway. Direct binding of transcription factors STAT3 and STAT5 to the Pim-1 promoter results in the transcription of Pim-1. The...

responsible for astrocyte differentiation through activation of the JAK2-STAT3 pathway via degradation of SOCS2. Furthermore, reduction of ATG5 levels...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

Brachyury gene Mesoderm developmental factor 1.000 + ggtcggcggAGGTgtctaccccg STAT3 Signal transducer and activator of transcription 3 Activate transcription...

PKA, POU2F1, PPARG, PPP1R13L, PRKCZ, REL, RFC1, RNF25, SIRT1, SOCS1, SP1, STAT3, TAF4B, TBP, TP53, and TRIB3. Gene knockout of NF-κB genes via homologous...

the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling". Neuron. 111 (22): 3619–3633.e8. doi:10.1016/j.neuron.2023.08...

Science. 1999;284(5415):770–776. Jin N, Lee J, Park SY, Han JS. NOTCH1-STAT3 signaling axis regulates astrocytic differentiation of hippocampal neural...

Wharton W Pledger WJ Sedivy JM Irby R Yeatman T Courtneidge SA Jove R. Stat3-mediated Myc expression is required for Src transformation and PDGF-induced...

signaling pathway, one of the JAK-STAT signaling pathways (i.e. the Jak1-STAT3 pathway), the c-Jun signaling pathway, and the NF-κB signaling pathway....

of PDGFR signaling. In addition, reactive oxygen species (ROS)-dependent STAT3 activation has been established to be a key downstream mediator of PDGFR...

Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism". Diabetes. 63 (2): 456–470. doi:10.2337/db13-0885....

Mycobacterium leprae, the bacteria that causes leprosy. Disrupting IL10/STAT3 signaling during vaccination through small molecules enhances vaccination...

by miR-203, and hypothesize that miR-203 regulation of SOCS3 and thus of STAT3 could have implications in keratinocyte functions. Another validated target...

transcription participate in this signalling cascade, namely STAT5, STAT1 and STAT3. After dimerisation, they translocate to nucleus to perform transcription...

M, et al. (February 2002). "Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death". Oncogene. 21 (7): 1038–1047...

hepatocyte-specific deletion of PTPN11/Shp2 promotes inflammatory signaling through the STAT3 pathway and hepatic inflammation/necrosis, resulting in regenerative hyperplasia...

Somatic hypermutation Specific granule Specol STAT protein STAT1 STAT2 STAT3 STAT4 STAT5 STAT6 Stem cell educator Stimulator of interferon genes Stromal...

indicates that salazinic acid is a potent modulator of Nrf2, NF-κB and STAT3 signaling pathways in colorectal cancer cells. The complete 1H and 13C NMR...

PROX1, PTMA, PPARA, PPARG, RORA, RELA, SMAD1, SMAD2, SMAD7, SNIP1, SS18, STAT3, STAT6, TAL1, TCF3, TFAP2A, TGS1, TRERF1, TSG101, THRA, TWIST1, YY1, and...

Delespine-Carmagnat M, Bouvier G, Bertoglio J (January 2000). "Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains...

"Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma". Oncogene. 28 (42):...

activation of specific genes and other downstream targets. JAK2, STAT1, STAT3 and STAT5 have been shown to be constitutively active in CML models. Where...

Aki D, et al. (2003). "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif". J. Biol. Chem...

Hodgkin and Reed-Sternberg tumor cells discovered recurrent mutations of STAT3, STAT5B, JAK1, JAK2 and PTPN1 that support the pivotal role of aberrant...

Z, Darnell JE (1995). "Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation". Cell. 82 (2): 241–50...

kinases (JAK1, Tyk2, and MAP kinases) and transcription factors, especially STAT3. It can induce IL-20 and IL-24 signaling when IL-22R1 pairs with IL-20R2...

PMID 11888273. Velichko S, Wagner TC, Turkson J, Jove R, Croze E (2002). "STAT3 activation by type I interferons is dependent on specific tyrosines located...

057.186.200 – stat2 transcription factor MeSH D12.776.157.057.186.300 – stat3 transcription factor MeSH D12.776.157.057.186.400 – stat4 transcription...

Walton KD, Sun K, Hanover JA, Furth PA, Hennighausen L (Dec 2001). "The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that...

visceral adipose tissue. Some of its roles include activation of GLUT4 and STAT3, and increasing acetylcholine and nitric oxide levels. It also inhibits...

Based on a previous study, intranasal delivery of exosomes loaded with a Stat3 inhibitor reduced brain inflammation and slowed brain tumor growth. Dendrimers...

Side Population (SP) SOX10 SOX2 SOX9 SP phenotype SSEA-1 SSEA-3 SSEA-4 Stat3 Stat5 Stella Stra8 Stro-1 Tartrate-resistant acid phosphatase (TRAcP) TdT...

suppress ITGB6 expression. Of note, binding regions for transcription factors STAT3 and C/EBPα were found, and basic normal cell expression of ITGB6 is thought...

phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation". Biochem. Biophys. Res. Commun. 297 (4): 811–7. doi:10...

"Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467....

expression. Some of examples of this are described below. miR-155 stimulates the STAT3 signaling pathway, and this is associated with cell survival and endocrine...

transcription factor signal transducer and activator of transcription 3 (STAT3) was identified as the therapeutic target for glioblastoma. GRCh38: Ensembl...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

Hyper-IgD syndrome; 260920; MVK Hyper-IgE recurrent infection syndrome; 147060; STAT3 Hyper-IgE recurrent infection syndrome, autosomal recessive; 243700; DOCK8...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

Lin, Caiyu; Jiang, Jianxin (2018-06-15). "Correction: Caveolin-1-mediated STAT3 activation determines electrotaxis of human lung cancer cells". Oncotarget...

Timofeeva OA, Lerman MI (Jul 2004). "STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets". Journal of Molecular Biology. 340...

NFE2L1 NFE2L2 NCOR2 NCOA1 PIN1 RBM39 RELA RB1 RFWD2 RUNX1 RUNX2 SMAD3 STAT1 STAT3 TBP TGIF1 c-Jun N-terminal kinases GRCh38: Ensembl release 89: ENSG00000177606...

Kong QY, et al. (2008). "Immunohistochemical profiling of Wnt, NF-kappaB, Stat3 and Notch signaling in human epidermal tumors". J. Dermatol. Sci. 52 (2):...

"Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells". Biochemical and Biophysical Research...

RUNX1 has been shown to interact with: C-Fos, C-jun, SUV39H1 TLE1, and VDR. Stat3 Ro5-3335 RUNX2 RUNX3 GRCh38: Ensembl release 89: ENSG00000159216 – Ensembl...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

of interleukins IL-6 and IL-8. However, the mechanism is not STAT1, but STAT3 dependent. Synthetic gene for ovine IFN-τ was produced using Pichia pastoris...

binds to PTPRD, this leads to the de-phosphorylation and de-activation of Stat3. PTPRD is highly expressed throughout the entire brain, especially in the...

Steven J. (2017-06-01). "Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non–Small Cell Lung Cancers"...

stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling". Cancer Letters. 370 (2): 260–7. doi:10.1016/j.canlet.2015.10...

mRNA and increases its degradation (DIF -1 and -3) Inhibition of ERK and STAT3 signaling (DIF -1) Inhibition of PAK1 activity in breast cancer cells (DIF-3...

Kieliszek AM, Tatari N, McKenna D, et al. (February 2023). "An HLA-G/SPAG9/STAT3 axis promotes brain metastases". Proceedings of the National Academy of...

modulate multiple STAT proteins activities. In response to the smoking, STAT3 and STAT6 signaling are stimulated to potentiate M2-like phenotype with...

regulated by β-catenin in fish. β-catenin activates the transcription factor stat3. Stat3 coordinates cell movements during gastrulation and contributes to establishing...

cell migration and proliferation in vitro via interaction with Rac1 and Stat3". Mol Med Rep. 9 (1): 173–179. doi:10.3892/mmr.2013.1766. PMID 24172987...

amplification, growth factor or oncogene induced expression by Src, Ras, ErbB2, STAT3, STAT5, impaired protein degradation, or chromosomal translocation. Gene...

phosphorylation of signal transducer and activator of transcription 3 (i.e. STAT3) in the crypts of affected colon tissue; and e) reduced colon mucosa integrity...

promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways". Blood. 99 (8): 2637–46. doi:10.1182/blood.V99.8.2637...

PABPC4-TYK2 in rare cases. They also show mutations in the JAK1 and/or STAT3 genes in 18% of cases; the MSC gene in 15% of cases, and the NOTCH1 gene...

Inflammation-Mediated Carcinogenesis and Prevents Doxorubicin-Induced Apoptosis via IL6/STAT3 Signaling in HCC". Clinical Cancer Research. 25 (13): 4141–4154. doi:10...

Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, et al. (October 2008). "STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination"...

maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway". Clinical Cancer Research. 20 (15): 4154–4166. doi:10.1158/1078-0432...

breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways". Molecular Cancer. 16 (1): 57. doi:10...

thus may mediate signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4 CD213a2 IL13RA2 - Interleukin-13 receptor...

H, Chung J, Kao HY, Yang YC (March 2003). "Tip60 is a co-repressor for STAT3". The Journal of Biological Chemistry. 278 (13): 11197–11204. doi:10.1074/jbc...

differentiation primary response 88, continuously activates NF-κB as well as the STAT3 and AP1 transcription factors. 3) Inactivating mutations in the NOTCH1 (8%...

V, Iorio R, et al. (December 2008). "The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early...

the phosphorylation of STAT3 on the serine residue at amino acid position 727 and subsequent Hes3 expression increase (STAT3-Ser/Hes3 Signaling Axis)...

Q9Y3M8 15951 STAT1 HGNC:11362; P42224 15952 STAT2 HGNC:11363; P52630 15953 STAT3 HGNC:11364; P40763 15954 STAT4 HGNC:11365; Q14765 15955 STAT5A HGNC:11366;...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

in mice overexpressing the GAST gene. JAK2 (Janus-activated kinase 2), STAT3 and kinases increases regulated by extracellular signals have also been...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

GADD45G is down regulated. It participates in negatively regulating the JAK-STAT3 signaling pathway. It acts as a tumor suppressor in HCC cells by promoting...

Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation". Mol. Cell. Biol. 20 (6): 2043–54. doi:10.1128/MCB.20.6.2043-2054...

receptor of Mregs induce differentiation of Mregs through activation of STAT3 signaling pathway. Some pathogens can promote the transformation of cells...

on IFNAR1 and IFNAR2 recruit STAT proteins (classically STAT1, STAT2, or STAT3, although STAT4, STAT5, and STAT6 may play a role in certain cell types)...

A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway". Molecular Carcinogenesis. 54 (Suppl 1): E81-93. doi:10...

protein. OSBP also acts as a sterol-dependant scaffold for the JAK2 and STAT3 proteins. OSBP is a multi-domain protein consisting of an N-terminal pleckstrin...

2018). "Influence of single nucleotide polymorphisms in pri-miR-124-1 and STAT3 genes on gastric cancer susceptibility". British Journal of Biomedical Science...

breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)". Journal...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

PGLYRP1 is secreted by microglial cells and initiates the TREM-1–Syk–Erk1/2–Stat3 signaling pathway in glial cells, which leads to the production of proinflammatory...

Hayden, J., Keeney, F., Nathanson, K.L., Herlyn, M. MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines. Oncogene April 29 [Epub...

Clinical Investigation and Nature Communications have highlighted the role of STAT3-enhancing germline mutations and other common genetic variants in modulating...

also signals via JAK-STAT pathways; it is capable of activating STAT1 and STAT3. The role of IL-35 in autoimmune conditions is well documented, with multiple...

Mirabella M, et al. (December 2008). "The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

V, Iorio R, et al. (October 2008). "The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early...

promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation". Oncotarget. 8 (8): 13174–13185. doi:10.18632/oncotarget...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

studies show binding of the C16ORF82 promoter by ARNT, ELF5, SMAD4, and STAT3. C16orf82 expression in humans has been observed in major organ systems...

interact with the following proteins: CHUK IKBKG IKK2, Myd88 NEMO SOCS1 STAT3 TRAF6 UBC, TOLLIP TLR4 IRAK-1 signaling is involved in rheumatoid arthritis...

inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine, first synthesized in 1971, was...

(2009). "A Point Mutation, E95D, in the Mumps Virus V Protein Disengages STAT3 Targeting from STAT1 Targeting". Journal of Virology. 83 (13): 6347–6356...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

causes activation of phosphatase PTEN, kinase MER, transcription factor STAT3 and adaptor protein p62 (DOK1). Pre-treatment of mice by IL-37 before injection...

transcription factors, such as p53, c-Jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms". Cell Reports. 43 (1) 113661: 113661–...

secreted by human neuroblastoma mediated doxorubicin resistance by activating STAT3 and inhibiting apoptosis". Molecular Medicine. 7 (6). Cambridge, Mass.:...

In breast cancer, Signal transducer and activator of transcription 3 (STAT3) has been reported to directly activate SALL4 expression. Furthermore, canonical...

decrease of AML1-ETO also results in lower levels of C-KIT kinases, Akt/PKB, STAT3, and Erk1/2 – all of which are involved in cell signaling and gene transcription...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

signalling. The signaling is mediated by Ras/Mapk, PI3K/Akt, c-Src and STAT3/5 and include cell proliferation, reduced apoptosis, altered cytoskeletal...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

leukemia inhibitory factor receptor beta, and the transcription factor STAT3. It has been implicated in the induction of IL-1 (via induction of corticosterone...

transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, STAT3, sterol-regulated element-binding proteins and androgen receptors are all...

024.342.200 – stat2 transcription factor MeSH D12.644.360.024.342.300 – stat3 transcription factor MeSH D12.644.360.024.342.400 – stat4 transcription...