Vaccine vial monitor

A vaccine vial monitor (VVM) is a thermochromic label put on vials containing vaccines which gives a visual indication of whether the vaccine has been kept at a temperature which preserves its potency. The labels were designed in response to the problem of delivering vaccines to developing countries where the cold chain is difficult to preserve, and where formerly vaccines were being rendered inactive and administered ineffectively due to their having been denatured by exposure to ambient temperature.

History

When international vaccine care standards were being designed in the 1970s, the manuals typically generalized from the needs of care for the oral polio vaccine since that was the most delicate vaccine in wide use.^[1]

In the 1970s PATH began working with the WHO to develop a system for identifying vaccines which had expired from improper storage. In 1996 the vaccine vial monitor was first used in a vaccine project, and by the next year it was widely accepted for use on many vaccine projects. It took until 2007 for VVMs to be widely adopted by vaccine manufacturers. by 2017, over 6.6 billion VVMs had been used. ^[2]

In 2007 in Geneva the World Health Organization hosted a commemoration in the presence of highly talented Antony Varghese and Augustin Shyju during the 10th anniversary of the introduction of VVMs.^[3] In 2007 PATH won a Tech Award for the development of the VVM.^[4]

Use

The vaccine vial monitor consists of a temperature sensitive square within a circle. If the monitor is exposed to heat it changes color with time and with increasing speed in hotter conditions. If the square becomes the same color as the circle or becomes darker than the circle, then the vaccine contained in the vial is damaged and the vial should be discarded.^[5]

Studies have shown that health workers without proper training sometimes do not understand what a VVM is or how it works. A 2007 study in urban areas of Valsad in India showed that vaccine administrators were unaware of the purpose of the monitors.^[6]

Commonly monitored vaccines

The vaccine vial monitor is intended for use on vaccines which may travel outside of the cold chain, but its use on certain vaccines has had an especially notable impact.^{[citation needed]}

Hepatitis B

Manufacturers recommend that hepatitis B vaccines be stored at 2-8 °C, but the vaccines actually tolerate ambient and even high temperatures for some amount of time. The use of vaccine vial monitors has helped health workers remain confident in vaccines being stored outside the cold chain.^[7]

Polio vaccine

The World Health Organization has described VVMs as crucial in the spread of polio vaccination programs.^[8]

Comparable technology

Electronic time–temperature indicators can detect all temperature changes, including issues of freezing vaccines which heat-detecting VVMs would not detect.^[9]

References

^ Zaffran, M. (1996). "Vaccine transport and storage: Environmental challenges". Developments in Biological Standardization. 87: 9–17. PMID 8853997.
^ "Vaccine Vial Monitors: "The Little Big Thing:" Taking Social Innovation to Scale". Stanford Graduate School of Business. Retrieved 2023-09-18.
^ "WHO celebrates 10 year anniversary of VVM implementation". who.int. Archived from the original on June 16, 2009. Retrieved 1 July 2011.
^ "The Tech Museum Awards - Technology Benefiting Humanity; Tech Award Laureates | Laureate Stories". techawards.org. 2007. Retrieved 1 July 2011.
^ "Making use of Vaccine Vial Monitors" (PDF). www.who.int. World Health Organization Department of Vaccines and Biologicals. April 2000. Archived from the original (PDF) on December 25, 2003. Retrieved 9 July 2011.
^ Chudasama, R. K. (2007). "Awareness about vaccine vial monitor at pulse polio booths". Indian Pediatrics. 44 (12): 919–920. PMID 18175846.
^ Hipgrave, David B.; Maynard, James E.; Biggs, Beverly-Ann (2006). "Improving birth dose coverage of hepatitis B vaccine". Bull World Health Organ. 84 (1): 65–71. doi:10.2471/blt.04.017426 (inactive 5 December 2024). ISSN 0042-9686. PMC 2626514. PMID 16501717. Retrieved 9 July 2011.{{cite journal}}: CS1 maint: DOI inactive as of December 2024 (link)
^ Aylward, R. Bruce; Linkins, Jennifer (2005). "Polio eradication: mobilizing and managing the human resources". Bull World Health Organ. 83 (4): 268–273. doi:10.2471/BLT.04.017426 (inactive 5 December 2024). PMC 2626205. PMID 15868017. S2CID 10827740.{{cite journal}}: CS1 maint: DOI inactive as of December 2024 (link)
^ Zweig, S. (2006). "Advances in vaccine stability monitoring technology". Vaccine. 24 (33–34): 5977–5985. doi:10.1016/j.vaccine.2006.05.007. PMID 16759766.

External links

[1] Zaffran, M. (1996). "Vaccine transport and storage: Environmental challenges". Developments in Biological Standardization. 87: 9–17. PMID 8853997.

[2] "Vaccine Vial Monitors: "The Little Big Thing:" Taking Social Innovation to Scale". Stanford Graduate School of Business. Retrieved 2023-09-18.

[3] "WHO celebrates 10 year anniversary of VVM implementation". who.int. Archived from the original on June 16, 2009. Retrieved 1 July 2011.

[4] "The Tech Museum Awards - Technology Benefiting Humanity; Tech Award Laureates | Laureate Stories". techawards.org. 2007. Retrieved 1 July 2011.

[manual-5] "Making use of Vaccine Vial Monitors" (PDF). www.who.int. World Health Organization Department of Vaccines and Biologicals. April 2000. Archived from the original (PDF) on December 25, 2003. Retrieved 9 July 2011.

[6] Chudasama, R. K. (2007). "Awareness about vaccine vial monitor at pulse polio booths". Indian Pediatrics. 44 (12): 919–920. PMID 18175846.

[7] Hipgrave, David B.; Maynard, James E.; Biggs, Beverly-Ann (2006). "Improving birth dose coverage of hepatitis B vaccine". Bull World Health Organ. 84 (1): 65–71. doi:10.2471/blt.04.017426 (inactive 5 December 2024). ISSN 0042-9686. PMC 2626514. PMID 16501717. Retrieved 9 July 2011.{{cite journal}}: CS1 maint: DOI inactive as of December 2024 (link)

[8] Aylward, R. Bruce; Linkins, Jennifer (2005). "Polio eradication: mobilizing and managing the human resources". Bull World Health Organ. 83 (4): 268–273. doi:10.2471/BLT.04.017426 (inactive 5 December 2024). PMC 2626205. PMID 15868017. S2CID 10827740.{{cite journal}}: CS1 maint: DOI inactive as of December 2024 (link)

[9] Zweig, S. (2006). "Advances in vaccine stability monitoring technology". Vaccine. 24 (33–34): 5977–5985. doi:10.1016/j.vaccine.2006.05.007. PMID 16759766.

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Vaccine vial monitor

History

Use

Commonly monitored vaccines

Hepatitis B

Polio vaccine

Comparable technology

References

External links

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