The Vance-Pontotoc Historic District, in Memphis, Tennessee, was a historic district which was listed on the National Register of Historic Places. It included 69 contributing buildings on 31 acres (13 ha).^[1] It was listed in 1980 for its architectural significance.^[1] It included a number of early shotgun houses, which the Tennessee Encyclopedia has noted were endangered and "disappearing rapidly".^[2] The shotgun houses and/or other residences included Late Victorian, Queen Anne, and Italianate styling.^[1]

The district borders made an irregular pattern along Vance and Pontotoc Avenues in Memphis.^[1] Twelve of the buildings were destroyed by fire between 1979 and 1982. Only 12 of the 65 listed buildings remain.^{[citation needed]} The district was delisted from the National Register on March 18, 1987.^[1]