ZAK

MAP3K20
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5HES
Identifiers
Aliases	MAP3K20, AZK, MLK7, MLT, MLTK, MRK, mlklak, pk, ZAK, SFMMP, sterile alpha motif and leucine zipper containing kinase AZK, mitogen-activated protein kinase kinase kinase 20, MLTKalpha, MLTKbeta, CNM6
External IDs	OMIM: 609479; MGI: 2443258; HomoloGene: 32331; GeneCards: MAP3K20; OMA:MAP3K20 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	173,268,015 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	72,272,954 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; body of tongue; ; saphenous vein; ; tail of epididymis; ; vena cava; ; urethra; ; seminal vesicula;
	Top expressed in
	interventricular septum; ; temporal muscle; ; ankle; ; triceps brachii muscle; ; digastric muscle; ; extraocular muscle; ; sternocleidomastoid muscle; ; soleus muscle; ; atrioventricular valve; ; intercostal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; ATP binding; magnesium ion binding; RNA binding;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	cell differentiation; intracellular signal transduction; cell cycle checkpoint signaling; phosphorylation; DNA damage checkpoint signaling; response to stress; cell death; protein phosphorylation; cytoskeleton organization; positive regulation of apoptotic process; cell cycle; response to radiation; cell population proliferation; embryonic digit morphogenesis; limb development; mitotic cell cycle checkpoint signaling; stress-activated MAPK cascade; cellular response to gamma radiation;
	Sources:Amigo / QuickGO
Orthologs
	51776
	65964
	ENSG00000091436
	ENSMUSG00000004085
	Q9NYL2
	Q9ESL4
	NM_016653; NM_133646
	NM_001164791; NM_023057; NM_178084
	NP_057737; NP_598407
	NP_001158263; NP_075544; NP_835185
	Wikidata
View/Edit Human	View/Edit Mouse

Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.^[5]

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5] ^[6]

Interactions

ZAK has been shown to interact with ZNF33A.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091436 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004085 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK".
^ Liu, Te-Chung; Huang, Chang-Jen; Chu, Yu-Chuan; Wei, Chih-Chang; Chou, Chun-Chieh; Chou, Ming-Yung; Chou, Chen-Kung; Yang, Jaw-Ji (11 August 2000). "Cloning and Expression of ZAK, a Mixed Lineage Kinase-like Protein Containing a Leucine-Zipper and a Sterile-Alpha Motif". Biochemical and Biophysical Research Communications. 274 (3): 811–816. doi:10.1006/bbrc.2000.3236. PMID 10924358.
^ Yang, Jaw-Ji (Jan 2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochem. Biophys. Res. Commun. 301 (1): 71–7. doi:10.1016/S0006-291X(02)02980-7. ISSN 0006-291X. PMID 12535642.

Lee, Jin-Sun (28 February 2018). "Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK". The Chinese Journal of Physiology. 61 (1): 25–34. doi:10.4077/CJP.2018.BAG528. PMID 29374956.