TRIB3

TRIB3
Identifiers
Aliases	TRIB3, C20orf97, NIPK, SINK, SKIP3, TRB3, tribbles pseudokinase 3
External IDs	OMIM: 607898; MGI: 1345675; HomoloGene: 10902; GeneCards: TRIB3; OMA:TRIB3 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	397,559 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,185,952 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; pancreatic ductal cell; ; gonad; ; islet of Langerhans; ; stromal cell of endometrium; ; upper lobe of left lung; ; optic nerve; ; body of pancreas; ; parotid gland; ; anterior pituitary;
	Top expressed in
	lumbar spinal ganglion; ; endothelial cell of lymphatic vessel; ; calvaria; ; yolk sac; ; submandibular gland; ; seminal vesicula; ; ascending aorta; ; semi-lunar valve; ; aortic valve; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; ubiquitin-protein transferase regulator activity; protein kinase inhibitor activity; kinase activity; protein binding; mitogen-activated protein kinase kinase binding; ATP binding; protein kinase binding; ubiquitin protein ligase binding;
Cellular component	cytosol; plasma membrane; nucleus;
Biological process	negative regulation of fat cell differentiation; regulation of transcription, DNA-templated; negative regulation of fatty acid biosynthetic process; negative regulation of protein kinase activity; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; response to endoplasmic reticulum stress; protein phosphorylation; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of ubiquitin-protein transferase activity; cellular response to insulin stimulus; regulation of MAP kinase activity; positive regulation of protein binding; negative regulation of transcription, DNA-templated; regulation of glucose transmembrane transport; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; apoptotic process; regulation of lipid metabolic process; negative regulation of protein kinase B signaling; regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
	57761
	228775
	ENSG00000101255
	ENSMUSG00000032715
	Q96RU7
	Q8K4K2
NM_021158; NM_001301188; NM_001301190; NM_001301193; NM_001301196;
	NM_001301201
	NM_144554; NM_175093
NP_001288117; NP_001288119; NP_001288122; NP_001288125; NP_001288130;
	NP_066981
	NP_780302
	Wikidata
View/Edit Human	View/Edit Mouse

Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1.^[7] TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target.^[8]^[9]