二丁酸雌二醇

二丁酸雌二醇
臨床資料
其他名稱	EDBu; Estradiol dibutanoate; Estradiol 3,17β-dibutanoate
给药途径	Intramuscular injection
藥物類別（英语：Drug class）	Estrogen; Estrogen ester
识别信息
CAS号	63042-23-9
ChemSpider	4956817;
UNII	VQZ6UH9WLR;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID50978982 ;
ECHA InfoCard	100.057.990
化学信息
化学式	C26H36O4
摩尔质量	412.57 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES O(C(CCC)=O)[C@]1CC[C@]([H])2[C@@]([H])3CCC4C=C(C=CC=4[C@@]3([H])CC[C@@]21C)OC(=O)CCC;
	InChI InChI=1S/C26H35O4/c1-4-6-24(27)29-18-9-11-19-17(16-18)8-10-21-20(19)14-15-26(3)22(21)12-13-23(26)30-25(28)7-5-2/h9,11,16,20-22H,4-8,10,12-15H2,1-3H3/t20-,21-,22+,26+/m1/s1; Key:YQLMZRSLVHCBEL-CQAGSAPUSA-N;

二丁酸雌二醇（英语：Estradiol dibutyrate或Estradiol dibutanoate），或名雌二醇二丁酸酯，是一种雌激素药物和一种雌激素酯，具体来说雌二醇的二酯，该药物现已不再使用。^[1]^[2]它是Triormon Depositum的一个成分，该药物是1950年代开发的由二丁酸雌二醇、己酸睾酮和庚酸羟孕酮的组合配方。^[2]

参见

雌激素酯列表
二丁酸雌二醇/庚酸羟孕酮/己酸睾酮（商品名为Triormon Depositum）

参考资料

^ Cacciari P. [Experimental research on estradiol dibutyrate]. Minerva Ginecol. August 1960, 12: 788–9. PMID 13689684 （意大利语）.
^ ^2.0 ^2.1 Ermiglia, G; Valli, P. Triormon depositum in climacteric syndrome. Curves of excretion of catabolites and duration of the therapeutic effect. Quaderni Clin. Ostet. E Ginecol. 1957, 12: 284–93. Triormon depositum (estradiol dibutyrate 3, testosterone caprylate 50, and hydroxyprogesterone heptanoate 30 mg.), administered in castor oil-benzyl benzoate soln. or polyvinylpyrrolidone suspension to 21 women in climacteric, was followed by estradiol, pregnanediol, and 17-keto steroid urinary curves, most with a peak at the 4th day, and approaching starting values at the 8-10th day. The therapeutic efficacy of the drug was satisfactory.

[pmid13689684-1] Cacciari P. [Experimental research on estradiol dibutyrate]. Minerva Ginecol. August 1960, 12: 788–9. PMID 13689684 （意大利语）.

[ErmigliaValli1957-2] 2.0 ^2.1 Ermiglia, G; Valli, P. Triormon depositum in climacteric syndrome. Curves of excretion of catabolites and duration of the therapeutic effect. Quaderni Clin. Ostet. E Ginecol. 1957, 12: 284–93. Triormon depositum (estradiol dibutyrate 3, testosterone caprylate 50, and hydroxyprogesterone heptanoate 30 mg.), administered in castor oil-benzyl benzoate soln. or polyvinylpyrrolidone suspension to 21 women in climacteric, was followed by estradiol, pregnanediol, and 17-keto steroid urinary curves, most with a peak at the 4th day, and approaching starting values at the 8-10th day. The therapeutic efficacy of the drug was satisfactory.

[1]

[2]

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二丁酸雌二醇

参见

参考资料

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