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ADGRF5
Identifiers
Aliases	ADGRF5, KPG_001, GPR116, adhesion G protein-coupled receptor F5
External IDs	MGI: 2182928; GeneCards: ADGRF5
Gene location (Human)
Chr.	Chromosome 6 (human)
End	46,954,943 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	43,770,448 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; visceral pleura; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; renal medulla; ; right ventricle; ; metanephric glomerulus; ; vena cava; ; pericardium;
	Top expressed in
	right lung; ; right lung lobe; ; left lung lobe; ; endothelial cell of lymphatic vessel; ; interventricular septum; ; myocardium of ventricle; ; extraocular muscle; ; digastric muscle; ; soleus muscle; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; apical part of cell; cytoplasmic vesicle; membrane;
Biological process	surfactant homeostasis; negative regulation of macrophage activation; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; energy reserve metabolic process; regulation of lipid metabolic process; fat cell differentiation; positive regulation of phospholipid biosynthetic process; glucose homeostasis; signal transduction; glomerular filtration; erythrocyte development; pharyngeal arch artery morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	221395
	224792
	ENSG00000069122
	ENSMUSG00000056492
	Q8IZF2
	G5E8Q8
	NM_001098518; NM_015234
	NM_001081178; NM_001357332
	NP_001091988; NP_056049
NP_001074647; NP_001344261; NP_001391458; NP_001391459; NP_001391465;
	NP_001391470; NP_001391475; NP_001391477
	Wikidata
View/Edit Human	View/Edit Mouse

Adhesion G protein-coupled receptor F5 is a protein that in humans is encoded by the ADGRF5 gene (previously GPR116).^[5]^[6]^[7] ADGRF5 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.^[8]^[9] It functions as a receptor for soluble FNDC4, an anti-inflammatory protein that is also involved in systematic glucose tolerance.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069122 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056492 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs: structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4. {{cite book}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link)
^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
^ "Entrez Gene: GPR116 G protein-coupled receptor 116".
^ Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMC 3695742. PMID 23684610.
^ Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7) e69451. Bibcode:2013PLoSO...869451F. doi:10.1371/journal.pone.0069451. PMC 3726689. PMID 23922714.
^ "Q8IZF2 · AGRF5_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-23.

Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069122 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056492 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs: structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4. {{cite book}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link)

[pmid12435584-6] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[entrez-7] "Entrez Gene: GPR116 G protein-coupled receptor 116".

[8] Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMC 3695742. PMID 23684610.

[9] Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7) e69451. Bibcode:2013PLoSO...869451F. doi:10.1371/journal.pone.0069451. PMC 3726689. PMID 23922714.

[10] "Q8IZF2 · AGRF5_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-23.

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ADGRF5

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