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Butamben

Butamben
Clinical data
Other namesn-butyl p-aminobenzoate
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
Topical
ATC code
  • none
Identifiers
  • Butyl 4-aminobenzoate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.002.107 Edit this at Wikidata
Chemical and physical data
FormulaC11H15NO2
Molar mass193.246 g·mol−1
3D model (JSmol)
Melting point58 °C (136 °F)
  • O=C(OCCCC)c1ccc(N)cc1
  • InChI=1S/C11H15NO2/c1-2-3-8-14-11(13)9-4-6-10(12)7-5-9/h4-7H,2-3,8,12H2,1H3 checkY
  • Key:IUWVALYLNVXWKX-UHFFFAOYSA-N checkY
  (verify)

Butamben is a local anesthetic. Proprietary names includes Alvogil in Spain and Alvogyl in Switzerland. It is one of three components in the topical anesthetic Cetacaine.

Chemistry

It is the ester of 4-aminobenzoic acid and butanol.[1] A white, odourless, crystalline powder. that is mildly soluble in water (1 part in 7000) and soluble in alcohol, ether, chloroform, fixed oils, and dilute acids. It slowly hydrolyses when boiled with water. Synonyms include Butamben, Butilaminobenzoato, and Butoforme.

Synthesis

Patents:[2][3] ~97%:[4] ~94%:[5] ~88%:[6] NA:[7][8]

The esterification between 4-Nitrobenzoic acid [62-23-7] (1) and 1-Butanol [71-36-3] (2) gives Butyl 4-Nitrobenzoate [120-48-9] (3). Bechamp reduction then gives Butamben (4).

Alternatively, 4-aminobenzoic acid can be used directly.

References

  1. ^ drugs.com Butamben
  2. ^ GB 148743, "Manufacture of normal butyl paramino benzoate", issued 1920, assigned to Ste Chim Usines Rhone. 
  3. ^ US 1440652, Adams R, Volwiler E, issued 1923, assigned to Abbott Labs. 
  4. ^ Morogina OK, Nasibulin AA, Klyuev MV (1998). "Liquid-Phase Hydrogenation of p-Nitrobenzoic Acid Esters on Palladium Catalysts". Petroleum Chemistry. 38 (4): 251–255.
  5. ^ Hosangadi BD, Dave RH (August 1996). "An efficient general method for esterification of aromatic carboxylic acids". Tetrahedron Letters. 37 (35): 6375–6378. doi:10.1016/0040-4039(96)01351-2.
  6. ^ Gök Y, Alici B, Cetinkaya E, Özdemir İ, Özeroğlu Ö (2010). "Ionic liquids as solvent for efficient esterification of carboxylic acids with alkyl halides". Turkish Journal of Chemistry. 34 (2): 187–192. doi:10.3906/kim-0904-39. S2CID 93020800.
  7. ^ Matsunaga Y, Sakamoto S, Togashi A, Tsujimoto M (July 1994). "Smectogenic Salts Formed by Combination of Alkyl p-Aminobenzoates and p-Ethyl-or p-Chlorobenzenesulfonic Acid". Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals. 250 (1): 161–166. doi:10.1080/10587259408028202.
  8. ^ Brill HC (June 1921). "Esters of Aminobenzoic Acids". Journal of the American Chemical Society. 43 (6): 1320–1323. doi:10.1021/ja01439a014.


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