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CD53
Identifiers
Aliases	CD53, MOX44, TSPAN25, CD53 molecule
External IDs	OMIM: 151525; MGI: 88341; HomoloGene: 20152; GeneCards: CD53; OMA:CD53 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	110,899,922 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	106,697,465 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; mononuclear cell; ; monocyte; ; spleen; ; appendix; ; lymph node; ; bone marrow; ; bone marrow cell; ; epithelium of nasopharynx;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; spleen; ; stroma of bone marrow; ; tibiofemoral joint; ; blood; ; right lung lobe; ; thymus; ; calvaria; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; cell surface; cell junction; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; cell-cell junction; immunological synapse; specific granule membrane; tertiary granule membrane;
Biological process	positive regulation of myoblast fusion; cell surface receptor signaling pathway; signal transduction; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	963
	12508
	ENSG00000143119
	ENSMUSG00000040747
	P19397
	Q61451
	NM_000560; NM_001040033; NM_001320638
	NM_007651
	NP_000551; NP_001035122; NP_001307567
	NP_031677
	Wikidata
View/Edit Human	View/Edit Mouse

Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.^[5]^[6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143119 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040747 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Korinek V, Horejsi V (Jul 1993). "Genomic structure of the human CD53 gene". Immunogenetics. 38 (4): 272–279. doi:10.1007/BF00188803. PMID 8319976. S2CID 6683727.
^ ^a ^b "Entrez Gene: CD53 CD53 molecule".

Horejsí V, Vlcek C (1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Lett. 288 (1–2): 1–4. Bibcode:1991FEBSL.288....1H. doi:10.1016/0014-5793(91)80988-F. PMID 1879540. S2CID 26316623.
Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Bell GM, Seaman WE, Niemi EC, Imboden JB (1992). "The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line". J. Exp. Med. 175 (2): 527–536. doi:10.1084/jem.175.2.527. PMC 2119111. PMID 1346273.
Angelisová P, Vlcek C, Stefanová I, et al. (1990). "The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens". Immunogenetics. 32 (4): 281–285. doi:10.1007/BF00187099. PMID 1700763. S2CID 42139537.
Amiot M (1991). "Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins". J. Immunol. 145 (12): 4322–5. doi:10.4049/jimmunol.145.12.4322. PMID 2258620.
Dianzani U, Bragardo M, Buonfiglio D, et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120". Eur. J. Immunol. 25 (5): 1306–1311. doi:10.1002/eji.1830250526. PMID 7539755. S2CID 37717142.
Carmo AM, Wright MD (1995). "Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity". Eur. J. Immunol. 25 (7): 2090–2095. doi:10.1002/eji.1830250743. PMID 7621882. S2CID 44551148.
Rasmussen AM, Blomhoff HK, Stokke T, et al. (1994). "Cross-linking of CD53 promotes activation of resting human B lymphocytes". J. Immunol. 153 (11): 4997–5007. doi:10.4049/jimmunol.153.11.4997. PMID 7963560.
Gonzalez ME, Pardo-Manuel de Villena F, Fernandez-Ruiz E, et al. (1994). "The human CD53 gene, coding for a four transmembrane domain protein, maps to chromosomal region 1p13". Genomics. 18 (3): 725–728. doi:10.1016/S0888-7543(05)80385-4. hdl:10261/72861. PMID 8307585.
Olweus J, Lund-Johansen F, Horejsi V (1993). "CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells". J. Immunol. 151 (2): 707–16. doi:10.4049/jimmunol.151.2.707. PMID 8335905.
Taguchi T, Bellacosa A, Zhou JY, et al. (1993). "Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents". Cytogenet. Cell Genet. 64 (3–4): 217–221. doi:10.1159/000133580. PMID 8404042.
Virtaneva KI, Angelisová P, Baumruker T, et al. (1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics. 37 (6): 461–465. doi:10.1007/BF00222471. hdl:10138/157839. PMID 8436422. S2CID 8899453.
Wright MD, Rochelle JM, Tomlinson MG, et al. (1993). "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication". Int. Immunol. 5 (2): 209–216. doi:10.1093/intimm/5.2.209. PMID 8452817.
Mannion BA, Berditchevski F, Kraeft SK, et al. (1996). "Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". J. Immunol. 157 (5): 2039–47. doi:10.4049/jimmunol.157.5.2039. PMID 8757325.
Szöllósi J, Horejsí V, Bene L, et al. (1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY". J. Immunol. 157 (7): 2939–46. doi:10.4049/jimmunol.157.7.2939. PMID 8816400.
Okochi H, Kato M, Nashiro K, et al. (1998). "Expression of tetra-spans transmembrane family (CD9, CD37, CD53, CD63, CD81 and CD82) in normal and neoplastic human keratinocytes: an association of CD9 with alpha 3 beta 1 integrin". Br. J. Dermatol. 137 (6): 856–863. doi:10.1111/j.1365-2133.1997.tb01544.x (inactive 15 July 2025). PMID 9470900.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
Nichols TC, Guthridge JM, Karp DR, et al. (1999). "Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes". Eur. J. Immunol. 28 (12): 4123–4129. doi:10.1002/(SICI)1521-4141(199812)28:12<4123::AID-IMMU4123>3.0.CO;2-G. PMID 9862348. S2CID 1333672.
Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.

External links

CD53+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD53 genome location and CD53 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143119 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040747 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8319976-5] Korinek V, Horejsi V (Jul 1993). "Genomic structure of the human CD53 gene". Immunogenetics. 38 (4): 272–279. doi:10.1007/BF00188803. PMID 8319976. S2CID 6683727.

[entrez-6] "Entrez Gene: CD53 CD53 molecule".

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[5]

[6]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
351–371	CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363 CD364 CD365 CD366 CD367 CD368 CD369 CD370 CD371
Category Commons

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

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CD53

See also

References

Further reading

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