JAM2

JAM2
Identifiers
Aliases	JAM2, C21orf43, CD322, JAM-B, JAMB, PRO245, VE-JAM, VEJAM, junctional adhesion molecule 2, IBGC8
External IDs	OMIM: 606870; MGI: 1933820; HomoloGene: 10929; GeneCards: JAM2; OMA:JAM2 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	25,717,562 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	84,622,816 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; tendon of biceps brachii; ; vena cava; ; internal globus pallidus; ; ganglionic eminence; ; pericardium; ; gastric mucosa; ; body of uterus; ; epithelium of colon; ; tibial nerve;
	Top expressed in
	interventricular septum; ; myocardium of ventricle; ; cumulus cell; ; right ventricle; ; cardiac muscles; ; neural layer of retina; ; deep cerebellar nuclei; ; iris; ; epithelium of lens; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein heterodimerization activity;
Cellular component	integral component of membrane; cell junction; plasma membrane; integral component of plasma membrane; membrane; bicellular tight junction;
Biological process	negative regulation of cell adhesion; extracellular matrix organization; leukocyte migration; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	58494
	67374
	ENSG00000154721
	ENSMUSG00000053062
	P57087
	Q9JI59
	NM_001270407; NM_001270408; NM_021219
	NM_023844
	NP_001257336; NP_001257337; NP_067042
	NP_076333
	Wikidata
View/Edit Human	View/Edit Mouse

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.^[5]^[6]^[7] JAM2 has also been designated as CD322 (cluster of differentiation 322).

Function

Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.^[7]

It is purported to promote lymphocyte transendothelial migration.^[8] It might also be involved with endothelial cell polarity, by associating to cell polarity protein PARD3 (PAR-3), together with JAM3.^[9]

Interactions

JAM2 has been shown to interact with PARD3.^[9]

It also interacts with the integrin dimer VLA-4 (also called α4β1).^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154721 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053062 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD (Aug 2000). "Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells". J Biol Chem. 275 (25): 19139–45. doi:10.1074/jbc.M003189200. PMID 10779521.
^ Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA (Nov 2000). "A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions". J Biol Chem. 275 (44): 34750–6. doi:10.1074/jbc.M002718200. PMID 10945976.
^ ^a ^b "Entrez Gene: JAM2 junctional adhesion molecule 2".
^ Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (October 2002). "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration". Blood. 100 (7): 2479–86. doi:10.1182/blood-2001-11-0098. PMID 12239159.
^ ^a ^b Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
^ Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA (August 2002). "JAM2 interacts with alpha4beta1. Facilitation by JAM3". J. Biol. Chem. 277 (31): 27589–92. doi:10.1074/jbc.C200331200. PMID 12070135.

External links

JAM2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q9JI59 (Mouse Junctional adhesion molecule B) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.