As described in a film publication,[2] Bart Carson (Carey) is in love with Lou (La Marr) and even goes to jail to save Walter A. Walker (Coxen), a man she says is her brother but who is really a husband who has deserted his wife and two children. After he learns the truth, Bart breaks out of jail and trails Walter, who falls off a train trying to escape. Bart then seeks refuge in a cabin with Mrs. Walker (Rich), where he is captured, but the officials have learned the truth and promise him a pardon.
Filming of Desperate Trails started on March 14, 1921, under the working title of Christmas Eve at Pilot Butte, and lasted until April 11, with Harry C. Fowler and Robert De Grasse serving as the photographers. The movie was released on July 9.[5]