Leukotriene E4

Leukotriene E₄
Names
	Systematic IUPAC name (5S,6R,7E,9E,11Z,14Z)-6-({(2R)-2-Amino-2-carboxyethyl}sulfanyl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid
Identifiers
CAS Number	75715-89-8 ;
3D model (JSmol)	Interactive image;
Abbreviations	LTE4
ChEBI	CHEBI:15650;
ChemSpider	4444402;
KEGG	C05952;
MeSH	Leukotriene+E4
PubChem CID	5280749;
UNII	8EYT8ATL7G ;
CompTox Dashboard (EPA)	DTXSID20897510 ;
	InChI InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19?,20-,21+/m0/s1 Key: OTZRAYGBFWZKMX-MPWKMEBCSA-N;
	SMILES CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)O)N;
Properties
Chemical formula	C23H37NO5S
Molar mass	439.61 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Leukotriene E₄ (LTE₄) is a cysteinyl leukotriene involved in inflammation. It is known to be produced by several types of white blood cells, including eosinophils, mast cells, tissue macrophages, and basophils, and recently was also found to be produced by platelets adhering to neutrophils.^[1] It is formed from the sequential conversion of LTC₄ to LTD₄ and then to LTE₄, which is the final and most stable cysteinyl leukotriene.^[2] Compared to the short half lives of LTC₄ and LTD₄, LTE₄ is relatively stable and accumulates in breath condensation, in plasma, and in urine, making it the dominant cysteinyl leukotriene detected in biologic fluids.^[3] Therefore, measurements of LTE₄, especially in the urine, are commonly monitored in clinical research studies.

Increased production and excretion of LTE₄ has been linked to several respiratory diseases, and urinary LTE₄ levels are increased during severe asthma attacks and are especially high in people with aspirin-exacerbated respiratory disease.^[4]

Studies have suggested that LTE₄ works through its own distinct receptor, and although one has not yet been discovered, research is ongoing to isolate and characterize an LTE₄-specific receptor.^[5]^[6]