List of estrogens available in the United States

This is a complete list of estrogens and formulations that are approved by the FDATooltip Food and Drug Administration and available in the United States. Estrogens are used as hormonal contraceptives, in hormone replacement therapy, and in the treatment of gynecological disorders.

Estrogen-only

Oral/sublingual pills

Conjugated estrogens (Premarin) – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg, 2.5 mg
Esterified estrogens (Amnestrogen, Estratab, Evex, Femogen, Menest) – 0.3 mg, 0.625 mg, 1.25 mg, 2.5 mg
Estradiol (Estradiol, Gynodiol, Innofem) – 0.5 mg, 1 mg, 2 mg
Estradiol acetate (Femtrace) – 0.45 mg, 0.9 mg, 1.8 mg
Synthetic conjugated estrogens (Cenestin, Enjuvia)^[1] – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg

Atypical (dual estrogen and nitrogen mustard alkylating antineoplastic):

Estramustine phosphate sodium (Emcyt) – 140 mg

Oral estradiol valerate (except in combination with dienogest as an oral contraceptive) is not available in the U.S. and is used primarily in Europe.^[2]

Transdermal forms

Patches

Estradiol (Alora, Climara, Esclim, Estraderm, Estradiol, Fempatch, Menostar, Minivelle, Vivelle, Vivelle-Dot) – 14 μg/24 hours, 25 μg/24 hours, 37.5 μg/24 hours, 50 μg/24 hours, 60 μg/24 hours, 75 μg/24 hours, 100 μg/24 hours

Gels

Estradiol (Divigel, Elestrin, Estrogel) – 0.06% (0.87 g/activation, 1.25 g/activation), 0.1% (0.25 g/packet, 0.5 g/packet, 1 g/packet)

Sprays

Estradiol (Evamist) – 1.53 mg/spray

Emulsions

Estradiol hemihydrate (Estrasorb) – 0.25%

Vaginal forms

Tablets

Estradiol (Estradiol, Vagifem) – 10 μg (25 μg discontinued)

Creams

Conjugated estrogens (Premarin) – 0.625 mg/g (0.0625%)
Estradiol (Estrace) – 0.01%
Synthetic conjugated estrogens (Synthetic Conjugated Estrogens A) – 0.625 mg/g (0.0625%)

Inserts

Estradiol (Imvexxy) – 4 μg, 10 μg

Rings

Estradiol (Estring) – 7.5 μg/24 hours
Estradiol acetate (Femring) – 50 μg/24 hours, 100 μg/24 hours

Intramuscular injection

Conjugated estrogens (Premarin) – 25 mg/vial
Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued)
Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL

Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.

Combined with progestins

For contraception

⇾ See here instead.

For menopausal symptoms

Oral pills

Conjugated estrogens and medroxyprogesterone acetate (Premphase (Premarin, Cycrin 14/14), Premphase 14/14, Prempro, Prempro (Premarin, Cycrin), Prempro/Premphase) – 0.3 mg / 1.5 mg; 0.45 mg / 1.5 mg; 0.625 mg / 2.5 mg; 0.625 mg / 5 mg
Estradiol and drospirenone (Angeliq) – 0.5 mg / 0.25 mg; 1 mg / 0.5 mg
Estradiol and norethisterone acetate (Activella, Amabelz) – 1 mg / 0.5 mg; 0.5 mg / 0.1 mg
Ethinylestradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg
Estradiol and progesterone (Bijuva) – 0.5 mg / 100 mg; 1 mg / 100 mg^[3]

Transdermal patches

Estradiol and levonorgestrel (Climara Pro) – 45 μg/24 hours / 15 μg/24 hours
Estradiol and norethisterone acetate (Combipatch) – 50 μg/24 hours / 0.14 mg/24 hours; 50 μg/24 hours / 0.25 mg/24 hours

Combined with other medications

Oral pills

Conjugated estrogens and bazedoxifene acetate (Duavee) – 20 mg / 0.45 mg

Notes

^ Mary C. Brucker; Tekoa L. King (8 September 2015). Pharmacology for Women's Health. Jones & Bartlett Learning. pp. 640–. ISBN 978-1-284-10811-8. Two types of synthetic estrogen mixtures exist that are primarily used for menopausal hormone therapy: synthetic conjugated estrogens and esterified estrogens. The synthetic conjugated estrogen mixtures are derived from yam or soy plants and contain several types of estrogen. Both synthetic conjugated estrogen products available in the United States (Cenestin with 9 estrogens and Enjuvia with 10 estrogens) contain the primary estrogens in CEE, but the products are not considered equivalent to Premarin.
^ Joseph S. Sanfilippo (January 1998). Primary Care in Obstetrics and Gynecology: A Handbook for Clinicians. Springer Science & Business Media. pp. 227–. ISBN 978-0-387-94739-6.
^ Pickar JH, Bon C, Amadio JM, Mirkin S, Bernick B (2015). "Pharmacokinetics of the first combination 17β-estradiol/progesterone capsule in clinical development for menopausal hormone therapy". Menopause. 22 (12): 1308–16. doi:10.1097/GME.0000000000000467. PMC 4666011. PMID 25944519.

References

"Drugs@FDA: FDA Approved Drug Products". United States Food and Drug Administration. Retrieved 16 November 2016.
"DailyMed". National Institutes of Health: United States National Library of Medicine. Retrieved 12 October 2016.