NE-CHMIMO

NE-CHMIMO
Legal status
Legal status	CA: Schedule II; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I; Illegal in Japan;
Identifiers
	IUPAC name [1-(Cyclohexylmethyl)-1H-indol-3-yl](naphthalen-1-yl)methanone;
CAS Number	1373876-11-9 ;
PubChem CID	139031057;
ChemSpider	81407778;
UNII	5FWB35TKQ2;
CompTox Dashboard (EPA)	DTXSID401046437 ;
Chemical and physical data
Formula	C26H25NO
Molar mass	367.492 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1cccc2ccccc12)c3cn(CC4CCCCC4)c5ccccc35;
	InChI InChI=1S/C26H25NO/c28-26(23-15-8-12-20-11-4-5-13-21(20)23)24-18-27(17-19-9-2-1-3-10-19)25-16-7-6-14-22(24)25/h4-8,11-16,18-19H,1-3,9-10,17H2; Key:HGJYPIZWMHHQKS-UHFFFAOYSA-N;

NE-CHMIMO (CHM-018) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.^[1]^[2]^[3] NE-CHMIMO is the 1-cyclohexylmethyl (instead of 1-pentyl) analogue of the first-generation synthetic cannabinoid JWH-018. The corresponding cyclohexylmethyl derivative of JWH-081 had also been reported several months earlier.^[4]

Legal status

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as NE-CHMIMO are Schedule I Controlled Substances.^[5]

NE-CHMIMO is a controlled substance in Japan as of November 2019.^[6]

^ Angerer V, Bisel P, Moosmann B, Westphal F, Auwärter V (September 2016). "Separation and structural characterization of the new synthetic cannabinoid JWH-018 cyclohexyl methyl derivative "NE-CHMIMO" using flash chromatography, GC-MS, IR and NMR spectroscopy". Forensic Science International. 266: e93–e98. doi:10.1016/j.forsciint.2016.05.031. PMID 27297324.
^ Franz F, Jechle H, Angerer V, Pegoro M, Auwärter V, Neukamm MA (May 2018). "Synthetic cannabinoids in hair - Pragmatic approach for method updates, compound prevalences and concentration ranges in authentic hair samples". Analytica Chimica Acta. 1006: 61–73. doi:10.1016/j.aca.2017.12.029. PMID 30016265.
^ "NE-CHMIMO". New Synthetic Drugs Database.
^ Blakey K, Boyd S, Atkinson S, Wolf J, Slottje PM, Goodchild K, McGowan J (March 2016). "Identification of the novel synthetic cannabimimetic 8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) and other designer drugs in herbal incense". Forensic Science International. 260: 40–53. doi:10.1016/j.forsciint.2015.12.001. PMID 26795397.
^ 21 U.S.C. § 812: Schedules of controlled substances
^ "指定薬物を指定する省令が公布されました｜厚生労働省". www.mhlw.go.jp (in Japanese). Ministry of Health, Labour and Welfare. Retrieved 2019-12-22.