Pioneer Street begins at EDSA in Mandaluyong, in front of the former site of Forum Robinsons and the Cybergate complex, the street curves looking eastwards. The section between Madison Street and Reliance Street is a one-way road eastbound.
The street soon enters the Pasig at Barangay Kapitolyo and finally terminates at the intersection with Shaw Boulevard. It continues to Barangay San Antonio as General Roxas Street.