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A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways...

A transmembrane domain (TMD, TM domain) is a membrane-spanning protein domain. TMDs may consist of one or several alpha-helices or a transmembrane beta...

Transmembrane protein 254 is a transmembrane protein that is encoded by the TMEM254 gene, it is predicted to have many orthologs across eukaryotes. TMEM254...

Transmembrane protein 182 is a protein that in humans is encoded by the TMEM182 gene. GRCh38: Ensembl release 89: ENSG00000170417 – Ensembl, May 2017...

G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors...

Transmembrane protein 175, or TMEM175, is a transmembrane protein that is thought to be an endolysosomal potassium channel. It is predicted to have many...

Transmembrane Protein 217 is a protein encoded by the gene TMEM217. TMEM217 has been found to have expression correlated with the lymphatic system and...

Transmembrane protein 268 is a protein that in humans is encoded by TMEM268 gene. The protein is a transmembrane protein of 342 amino acids long with eight...

Transmembrane channels, also called membrane channels, are pores within a lipid bilayer. The channels can be formed by protein complexes that run across...

SID1 transmembrane family member 1 is a protein that in humans is encoded by the SIDT1 gene. The protein encoded by this gene belongs to SID1 family of...

eukaryotes also referred to as the transmembrane 4 superfamily (TM4SF) proteins. These proteins have four transmembrane alpha-helices and two extracellular...

Transmembrane protein 94 is a protein that in humans is encoded by the TMEM94 gene. GRCh38: Ensembl release 89: ENSG00000177728 – Ensembl, May 2017 GRCm38:...

Topology of a transmembrane protein refers to locations of N- and C-termini of membrane-spanning polypeptide chain with respect to the inner or outer...

Transmembrane protein 19 is a protein that in humans is encoded by the TMEM19 gene. The TMEM19 gene is located on chromosome 12(12q21.1) spanning 18,966...

Transmembrane protein 179 is a protein that in humans is encoded by the TMEM179 gene. The function of transmembrane protein 179 is not yet well understood...

Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells. They act in cell...

Transmembrane protein 131-like (TMEM131L protein), alternatively named uncharacterized protein KIAA0922 (KIAA0922 protein), is an integral transmembrane...

Signaling threshold-regulating transmembrane adapter 1 is a protein that in humans is encoded by the SIT1 gene. GRCh38: Ensembl release 89: ENSG00000137078...

Transmembrane protein 150B is a protein that in humans is encoded by the TMEM150B gene. The protein belongs to the DRAM (damage-regulated autophagy modulator)...

Transmembrane protein 72 is a protein that in humans is encoded by the TMEM72 gene. GRCh38: Ensembl release 89: ENSG00000187783 – Ensembl, May 2017 GRCm38:...

protein is a transmembrane protein that spans the lipid bilayer only once. These proteins may constitute up to 50% of all transmembrane proteins, depending...

permanent part of a cell membrane and can either penetrate the membrane (transmembrane) or associate with one or the other side of a membrane (integral monotopic)...

Transmembrane protein 201 is a protein that in humans is encoded by the TMEM201 gene. GRCh38: Ensembl release 89: ENSG00000188807 – Ensembl, May 2017...

Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene. The Transmembrane protein 151B gene is also known as TMEM151B...

Transmembrane protein 247 (also known as TMEM247 or transmembrane protein ENSP00000343375) is a multi-pass transmembrane protein of unknown function found...

MARVEL transmembrane domain-containing 4 (i.e. CMTM4), formerly termed chemokine-like factor superfamily 4 (i.e. CKLFSF4), is a small transmembrane protein...

COVID‑19 vaccines. The M protein is the viral protein responsible for the transmembrane transport of nutrients. It is the cause of the bud release and the formation...

SID1 transmembrane family member 2 is a protein that in humans is encoded by the SIDT2 gene. GRCh38: Ensembl release 89: ENSG00000149577 – Ensembl, May...

Membrane potential (also transmembrane potential or membrane voltage) is the difference in electric potential between the interior and the exterior of...

Transmembrane protein 238 is a transmembrane protein that in humans is encoded by the TMEM238 gene. The Homo sapiens TMEM238 gene is related to Bardet-Biedl...

is a fragment derived from the larger Aβ precursor protein (APP), a transmembrane protein that penetrates the cell's membrane. APP is critical to neuronal...

to the biological membrane. All transmembrane proteins can be classified as IMPs, but not all IMPs are transmembrane proteins. IMPs comprise a significant...

Transmembrane protein 134 is a protein encoded by the TMEM134 gene. TMEM134 does not have any other known aliases. There are two transmembrane domains...

Transmembrane protein 62 (TMEM62) is a protein which in Homo Sapiens is encoded by the TMEM62 gene. TMEM62 is an uncharacterized transmembrane protein...

Transmembrane epididymal protein 1 is a transmembrane protein encoded by the TEDDM1 gene. TEDDM1 is also commonly known as TMEM45C and encodes 273 amino...

Transmembrane protein 212 is a protein that in humans is encoded by the TMEM212 gene. The protein consists of five transmembrane domains and localizes...

Cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and anion channel in vertebrates that is encoded by the CFTR gene. Geneticist...

Transmembrane protein 89 (TMEM89) is a protein that in humans is encoded by the TMEM89 gene. The TMEM89 gene is found on the minus strand of chromosome...

Multiple C2 domains, transmembrane 2 is a protein that in humans is encoded by the MCTP2 gene. GRCh38: Ensembl release 89: ENSG00000140563 – Ensembl,...

Transmembrane protein 131 (TMEM131) is a protein that is encoded by the TMEM131 gene in humans. The TMEM131 protein contains three domains of unknown...

Transmembrane protein 243 is a protein that in humans is encoded by the TMEM243 gene. GRCh38: Ensembl release 89: ENSG00000135185 – Ensembl, May 2017...

Transmembrane 6 superfamily member 1 is a protein that in humans is encoded by the TM6SF1 gene. GRCh38: Ensembl release 89: ENSG00000136404 – Ensembl...

Transmembrane protein 51 is a protein in humans that is encoded by the TMEM51 gene. It is located on the first chromosome (1p36.21) and has 6 isoforms...

expressed seven transmembrane protein is a protein that in humans is encoded by the DCSTAMP gene. This gene encodes a seven-pass transmembrane protein that...

typically against their concentration gradient. These are called transmembrane ATPases. Transmembrane ATPases import metabolites necessary for cell metabolism...

Transmembrane protein 57 is a protein that in humans is encoded by the TMEM57 gene. Endoplasmic reticulum protein 57 (Erp57) Vicinal (chemistry) GRCh38:...

common protein structure element that crosses biological membranes (transmembrane protein), presumably because the helical structure can satisfy all backbone...

Growth hormone-inducible transmembrane protein (GHITM), also known as transmembrane BAX inhibitor motif containing protein 5 (TMBIM5), is a protein that...

Transmembrane and coiled-coil domains 2 is a protein that in humans is encoded by the TMCO2 gene. GRCh38: Ensembl release 89: ENSG00000188800 – Ensembl...

Transmembrane protein 126A is a mitochondrial transmembrane protein of unknown function coded for by the TMEM126A gene. A nonsense mutation in the TMEM126A...

Transmembrane protein 255A is a protein that is encoded by the TMEM255A gene. TMEM255A is often referred to as family with sequence similarity 70, member...

Transmembrane Protein 81 or TMEM81 is a protein that in humans is encoded by the TMEM81 gene. TMEM81 is a poorly-characterized transmembrane protein which...

Transmembrane protein 132B is a protein encoding gene that encodes the human TMEM132B protein. Variant 1 of human TMEM132B consists of 1078 amino acids...

Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) is a protein that...

classified as a type I transmembrane protein. While this protein is not well understood by the scientific community, the transmembrane domain of SMIM14 may...

Formate dehydrogenase consists of two transmembrane domains; three α-helices of the β-subunit and four transmembrane helices from the gamma-subunit. The...

while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism. The GLP-1 receptor is a transmembrane protein composed...

Transmembrane protein 222 is a protein that in humans is encoded by the TMEM222 gene. One notable feature of the protein encoded by this gene is the presence...

Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. Two transcript variants encoding 560 and 572 amino acid isoforms...

Osteoclast stimulatory transmembrane protein is a protein that in humans is encoded by the OCSTAMP gene. GRCh38: Ensembl release 89: ENSG00000149635 –...

encoded by the SLC5A5 gene. It is a transmembrane glycoprotein with a molecular weight of 87 kDa and 13 transmembrane domains, which transports two sodium...

membrane potential can be defined as a relatively stable, ground value of transmembrane voltage in animal and plant cells. Because the membrane permeability...

encoded by the SCIMP gene in humans. SCIMP belongs to the family of transmembrane adaptor proteins (TRAP) which do not directly associate with a receptor...

Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene. This gene encodes a member of the...

Transmembrane protein 251, also known as C14orf109 or UPF0694, is a protein that in humans is encoded by the TMEM251 gene. One notable feature of this...

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene. The protein encoded by this gene is a member of the transmembrane...

Transmembrane Protein 144 (TMEM144) is a protein in humans encoded by the TMEM144 gene. Transmembrane Protein 144 is located on the plus strand of chromosome...

Transmembrane protein 252 is a protein that, in humans, is encoded by the TMEM252 gene. Transmembrane protein 252 (TMEM252), otherwise known as chromosome...

functions by acting as a stimulator of the protein cystic fibrosis transmembrane conductance regulator (CFTR). Rowe SM, Jones I, Dransfield MT, Haque...

Transmembrane serine protease 11F is a protein that is encoded by the TMPRSS11F gene in humans. GRCh38: Ensembl release 89: ENSG00000198092 – Ensembl...

TMEM230 or transmembrane protein 230 is a protein that in humans is encoded by the TMEM230 gene. This gene encodes a multi-pass transmembrane protein that...

Transmembrane protein 151A, also known as TMEM151A, is a protein that is encoded by the TMEM151A gene. The gene encoding transmembrane protein 151A is...

Transmembrane protein 61 (TMEM61) is a protein that is encoded by the TMEM61 gene in humans. It is located on the first chromosome in humans and is highly...

TMEM44 (Transmembrane protein 44) is a protein that in humans is encoded by the TMEM44 gene. DKFZp686O18124 is a synonym of TMEM44. TMEM44 gene has 14...

compartmentalized by actin-based membrane-skeleton "fences" and anchored transmembrane protein "pickets". This model differs from older cell membrane structure...

CKLF like MARVEL transmembrane domain-containing 7 (i.e. CMTM7), previously termed chemokine-like factor superfamily 7 (i.e. CKLFSF7), is a protein that...

Transmembrane Protein 205 (TMEM205) is a protein encoded on chromosome 19 by the TMEM205 gene. TMEM205 is located on the minus strand of chromosome 19...

to 65 amino acyl residues in length that exhibit a single N-terminal transmembrane domain. A representative list of proteins belonging to the Vibrio Holin...

multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed...

pathway. A more complex instance of crosstalk can be observed with transmembrane crosstalk between the extracellular matrix (ECM) and the cytoskeleton...

Transmembrane Protein 176B, or TMEM176B is a transmembrane protein that in humans is encoded by the TMEM176B gene. It is thought to play a role in the...

bindings site can bind copper, zinc, collagen and heparan sulfate. The transmembrane region of APLP2 (residues 693-716) is helical in structure. The cytoplasmic...

TMEM143 (Transmembrane protein 143) is a protein that in humans is encoded by TMEM143 gene. TMEM143, a dual-pass protein (two transmembrane domains), is...

a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic...

The CKLF-like MARVEL transmembrane domain-containing family (CMTM), previously termed the chemokine-like factor superfamily (CKLFSF), consists of 9 proteins...

tiger samples revealed that this phenotype is caused by a mutation of a transmembrane aminopeptidase gene. Around 37% of the Simlipal tiger population has...

(sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered...

Transmembrane protein 215 is a protein that in humans is encoded by the TMEM215 gene. GRCh38: Ensembl release 89: ENSG00000188133 – Ensembl, May 2017...

A transport protein (variously referred to as a transmembrane pump, transporter, escort protein, acid transport protein, cation transport protein, or...

Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene. It belongs to the TMPRSS family of proteins, whose members...

TMEM69, also known as Transmembrane protein 69, is a protein that in humans is encoded by the TMEM69 gene. A notable feature of the protein encoded by...

is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine...

classified by their location. Cell surface receptors, also known as transmembrane receptors, include ligand-gated ion channels, G protein-coupled receptors...

Transmembrane protein 98 is a single-pass membrane protein that in humans is encoded by the TMEM98 gene. The function of this protein is currently unknown...

peptides found within the Kell blood group glycoprotein, a 93-kilodalton transmembrane zinc-dependent endopeptidase which is encoded by the gene KEL, and is...

Transmembrane protein 82 (TMEM82) is a protein encoded by the TMEM82 gene in humans. The TMEM82 gene is found on chromosome 1 (1p36.21) from 15,742,499...

Transmembrane and coiled-coil domain 6, TMCO6, is a protein that in humans is encoded by the TMCO6 gene with aliases of PRO1580, HQ1580 or FLJ39769.1...

as well as supercritical liquids and gases. Transmembrane protein channels and transporters: Transmembrane proteins extend through the lipid bilayer of...

the protein family Dispanin is another name for Interferon-induced transmembrane protein (IFITM). This refers to a family of protein domains which have...

as lipoproteins, since they are formed by lipids and proteins. Some transmembrane proteolipids, especially those found in bacteria, are referred to as...

Transmembrane and tetratricopeptide repeat containing 1 is a protein that in humans is encoded by the TMTC1 gene. GRCh38: Ensembl release 89: ENSG00000133687...

Transmembrane emp24 domain-containing protein 2 is a protein that in humans is encoded by the TMED2 gene. TMED2 has been shown to interact with GORASP1...

function cation transmembrane transporter activity zinc ion transmembrane transporter activity protein binding manganese ion transmembrane transporter activity...

Transmembrane protein 160 is a protein that in humans is encoded by the TMEM160 gene. GRCh38: Ensembl release 89: ENSG00000130748 – Ensembl, May 2017...

Transmembrane channel-like protein 2 is a protein that in humans is encoded by the TMC2 gene. This gene is considered a member of a gene family predicted...

receptors and enzyme linked receptors. Ion channels receptors are large transmembrane proteins with a ligand activated gate function. When these receptors...

Transmembrane protease, serine 6 (also known as matriptase-2) is an enzyme that in humans is encoded by the TMPRSS6 gene. Based on twin studies, mutations...

Ribonucleoside (NR) Uptake Permease (PnuC) Family (TC# 4.B.1) is a family of transmembrane transporters that is part of the TOG superfamily. Close PnuC homologues...

Proline-rich transmembrane protein 2 is a protein that in humans is encoded by the PRRT2 gene. This gene encodes a transmembrane protein containing a...

Transmembrane serine protease 7 is a protein that in humans is encoded by the TMPRSS7 gene. GRCh38: Ensembl release 89: ENSG00000176040 – Ensembl, May...

Transmembrane protein 101 (TMEM101) is a protein that in humans is encoded by the TMEM101 gene. The TMEM101 protein has been demonstrated to activate...

The Transmembrane protein with an EGF-like and two follistatin-like domains 2 (TMEFF2) gene is located on chromosome 2q32-q33 and encodes a 374-residue...

It is a member of the tumor necrosis factor superfamily, a family of transmembrane proteins that are cytokines, chemical messengers of the immune system...

Transmembrane protein 9 is a protein that in humans is encoded by the TMEM9 gene. GRCh38: Ensembl release 89: ENSG00000116857 – Ensembl, May 2017 GRCm38:...

cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role...

any other ion channel family of any other known proteins. They have 4 transmembrane domains and form hexamers. ORAI channels are activated upon the depletion...

Transmembrane protein 273 (TMEM273) aka C10orf128, is a protein which in humans is encoded by the TMEM273 gene. This protein is found within the topological...

Interferon-induced transmembrane protein 5 is a gene that encodes a membrane protein thought to play a role in bone mineralization. The gene is located...

four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Claudins are small (20–24/27 kilodalton (kDa)) transmembrane proteins...

members are transmembrane proteins, which are embedded in the cell membrane. All Frizzled family members have two folded domains: a transmembrane domain,...

This group of enzymes usually utilizes NADP+ or NAD+ as cofactors. Transmembrane oxidoreductases create electron transport chains in bacteria, chloroplasts...

Transmembrane protein 271, or TMEM271 is a protein in Homo sapiens encoded by the TMEM271 gene, located at 4p16.3 on the minus strand. The protein is...

Transmembrane protease, serine 3 is an enzyme that in humans is encoded by the TMPRSS3 gene. This gene encodes a member of the serine protease family...

Transmembrane channel like 3 is a protein that in humans is encoded by the TMC3 gene. GRCh38: Ensembl release 89: ENSG00000188869 – Ensembl, May 2017...

Sheddases are membrane-bound enzymes that cleave extracellular portions of transmembrane proteins, releasing the soluble ectodomains from the cell surface. Many...

of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions...

transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases...

Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. It is an Fc receptor which facilitates...

that bind cholesterol. They are commonly located in alpha helices of transmembrane domains within integral membrane proteins, although examples in β-strands...

the mitochondrial enzymes hCA VA/VB, the cytosolic hCA VII, and the transmembrane isoform hCA XII were potently activated. Some of these enzymes (hCA...

EC 1.9.3.1, now reclassified as a translocase EC 7.1.1.9) is a large transmembrane protein complex found in bacteria, archaea, and the mitochondria of...

Transmembrane and coiled-coil domains 4, TMCO4, is a protein in humans that is encoded by the TMCO4 gene. Currently, its function is not well defined...

11 transmembrane domains. For SERINC5 to localize itself to the plasma membrane to inhibit infectivity by viruses, an extra c-terminal transmembrane domain...

zipper-EF-hand containing transmembrane protein 1 is a protein that in humans is encoded by the LETM1 gene. The LETM1 protein has a transmembrane domain and a casein...

The sarcoglycans are a family of transmembrane proteins (α, β, γ, δ or ε) involved in the protein complex responsible for connecting the muscle fibre...

Transmembrane protein 150A is a protein that, in humans, is encoded by the TMEM150A gene. GRCh38: Ensembl release 89: ENSG00000168890 – Ensembl, May 2017...

Transmembrane protein 26 is a protein that in humans is encoded by the TMEM26 gene. GRCh38: Ensembl release 89: ENSG00000196932 – Ensembl, May 2017 GRCm38:...

cause of this coat pattern was found to be a mutation in the gene for transmembrane aminopeptidase (Taqpep), the same gene responsible for the striped "mackerel"...

protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major...

is a protein which in humans is encoded by the gene CNNM3. It is a transmembrane protein which is thought to help mediate the transport of magnesium...

involved in cholesterol homeostasis. The sigma-2 receptor is a four-pass transmembrane protein located in the endoplasmic reticulum. It has been found to play...

Interferon-induced transmembrane protein 2 is a protein that in humans is encoded by the IFITM2 gene. IFITM1 is a member of the IFITM family (Interferon-induced...

Membrane distillation (MD) is a thermally driven separation process in which separation is driven by phase change. A hydrophobic membrane presents a barrier...

powers the ion pumps maintaining these gradients. As a result, the transmembrane ion gradients run down, and glutamate transporters reverse their direction...

Transmembrane emp24 domain-containing protein 5 is a protein that in humans is encoded by the TMED5 gene. TMED5 (transmembrane emp24 domain-containing...

SLC26A5 family; they are protein receptors whose main function is the transmembrane movement of amino acids and their derivatives. This family of receptors...

Transmembrane protein 145 is a protein, which in humans, is encoded by the TMEM145 gene. TMEM145 has been associated with tumor suppression in breast...

Transmembrane protein 127 (TMEM127) is a transmembrane protein which is encoded by the TMEM127 gene. It has been demonstrated to be a negative regulator...

highly hydrophobic transmembrane protein of unknown function. ORF7b protein is a transmembrane protein with a single transmembrane helix whose membrane...

nucleotide binding organic anion transmembrane transporter activity ATPase activity ATP binding purine nucleotide transmembrane transporter activity ATPase-coupled...

Transmembrane and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the TMCO1 gene. GRCh38: Ensembl release 89: ENSG00000143183...

transmembrane 4 alpha is a protein that in humans is encoded by the LAPTM4A gene. This gene encodes a protein that has four predicted transmembrane domains...

TMEM106C is a gene that encodes the transmembrane protein 106C (TMEM106C) in Homo sapiens It has been found to be overexpressed in cancer cells and also...

Prolyl 4-hydroxylase, transmembrane is a protein that in humans is encoded by the P4HTM gene. The product of this gene belongs to the family of prolyl...

Biophysics at Johns Hopkins University. She investigates the energetics of transmembrane helix-helix interactions. Fleming was awarded the 2020 Protein Society...

YedZ (TC# 5.B.7) of E. coli has been examined topologically and has 6 transmembrane segments (TMSs) with both the N- and C-termini localized to the cytoplasm...

The phosphotransferases system (PTS-GFL) superfamily is a superfamily of phosphotransferase enzymes that facilitate the transport of glucose, glucitol...

Transmembrane protein 221 (TMEM221) is a protein that in humans is encoded by the TMEM221 gene. The function of TMEM221 is currently not well understood...

Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in a cell's electrical membrane...

MagT1 is expressed as a 335 amino acid polypeptide which includes five transmembrane helices. The nascent polypeptide possesses a cleavage site after the...

TMEM106A is a gene that encodes the transmembrane protein 106A (TMEM106A) in Homo sapiens. It is located at 17q21.31 on the plus strand next to cancer-related...

pore-forming holins between 80 and 90 amino acyl residues in length with 2 transmembrane segments (TMSs). A representative list of proteins belonging to this...

TMEM156 is a gene that encodes the transmembrane protein 156 (TMEM156) in Homo sapiens. It has the clone name of FLJ23235. TMEM156 is located on the short...

Transmembrane protein 63A is a protein that in humans is encoded by the TMEM63A gene. The mature human protein is approximately 92.1 kilodaltons (kDa)...

Fat storage-inducing transmembrane protein 2 (FITM2) affects the formation of triglyceride lipid droplets (LD). It is expressed in high quantities in...

Transmembrane protein 242 (TMEM242) is a protein that in humans is encoded by the TMEM242 gene. The tmem242 gene is located on chromosome 6, on the long...

the difference between the thicknesses of hydrophobic regions of a transmembrane protein and of the biological membrane it spans. In order to avoid unfavorable...

Notch 1 is a single-pass transmembrane receptor. This gene encodes a member of the Notch family. Members of this type 1 transmembrane protein family share...

Transmembrane protein 8B is a protein that in humans is encoded by the TMEM8B gene. It encodes for a transmembrane protein that is 338 amino acids long...

protein threading, ab initio methods, secondary structure prediction, and transmembrane helix and signal peptide prediction. Below is a list which separates...

Transmembrane protein 126B is a protein that in humans is encoded by the TMEM126B gene. TMEM126B is a mitochondrial transmembrane protein which is a component...

MFSD8, which functions as a lysosomal transmembrane protein. Northern epilepsy: CLN8 encodes for CLN8, a transmembrane protein of the endoplasmic reticulum...

III domain-containing protein 5, the precursor of irisin, is a type I transmembrane glycoprotein that is encoded by the FNDC5 gene. Irisin is a cleaved...

Transmembrane protein 130 is a protein that in humans is encoded by the TMEM130 gene. GRCh38: Ensembl release 89: ENSG00000166448 – Ensembl, May 2017...

belongs to the family of bacterial transmembrane rhodopsins (retinylidene proteins). In 1971, the first microbial transmembrane rhodopsin - Bacteriorhodopsin...

is also known as Transmembrane protein 8A, Transmembrane Protein 6, Five-Span Transmembrane Protein M83, TMEM6, TMEM8, Transmembrane protein 8 and M83...

MARVEL transmembrane domain-containing 6 (i.e. CMTM6), previously termed chemokine-like factor superfamily 6 (i.e. CKLFSF6), is a transmembrane protein...

objective is to determine whether the protein in question is a soluble or a transmembrane protein. SOSUI's algorithm was developed in 1996 at Tokyo University...

in humans. Family members have a shared architecture containing five transmembrane domains. Yip1 domain family members are found in all eukaryotes. The...

NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular...

sequence and structure, have been characterised to date: soluble and transmembrane proton-pumping pyrophosphatases (sPPases and H(+)-PPases, respectively)...

An immune receptor (or immunologic receptor) is a receptor, usually on a cell membrane, which binds to a ligand (usually another protein, such as cytokine)...

bonding systems. PnB systems have also been shown to be capable of transmembrane anion transport, in which lipophilic organopnictogen compounds bind...

Mibefradil Niflumic acid Activators Carbachol CFTRTooltip Cystic fibrosis transmembrane conductance regulator Blockers Glibenclamide Lonidamine Piretanide Activators...

activity protein heterodimerization activity bile acid transmembrane transporter activity transmembrane transporter activity Cellular component integral component...

TMPad (the TransMembrane Protein Helix-Packing Database) is a repository of helix-helix interactions in membrane proteins Alpha helix membrane protein...

proteins to and from the Golgi apparatus. These ER membrane proteins are transmembrane proteins that are then embedded into the ER membrane after transport...

Generally, the transmembrane domain from the most membrane-proximal component of the endodomain is used, but different transmembrane domains result in...

Transmembrane protein 261 is a protein that in humans is encoded by the TMEM261 gene located on chromosome 9. TMEM261 is also known as C9ORF123 and DMAC1...

Mibefradil Niflumic acid Activators Carbachol CFTRTooltip Cystic fibrosis transmembrane conductance regulator Blockers Glibenclamide Lonidamine Piretanide Activators...

between 125 and 140 amino acyl residues (aas) in length and exhibit 4 transmembrane segments (TMSs), although at least one putative holin (TC# 9.B.185.1...

The oxysterol-binding protein (OSBP)-related proteins (ORPs) are a family of lipid transfer proteins (LTPs). Concretely, they constitute a family of sterol...

ER retention mechanisms. The amino acid chain of transmembrane proteins, which often are transmembrane receptors, passes through a membrane one or several...

model on the bottom-right, bound to CFTR docked in a cleft formed by transmembrane helices at the protein–lipid interface. Elexacaftor and tezacaftor act...

Transmembrane protein 200A is a protein that in humans is encoded by the TMEM200A gene. GRCh38: Ensembl release 89: ENSG00000164484 – Ensembl, May 2017...

size from 129 to 255 amino acyl residues (aas) and exhibiting 4 to 7 transmembrane segments (TMSs). A representative list of proteins belonging to the...

encoded by the FZD6 gene. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6...

including amphioxus and most vertebrate species. The protein is a type I transmembrane receptor of ligands Dickkopf1, Dickkopf2, Dickkopf3, Dickkopf4, EpCAM...

membrane. FO is a water insoluble protein with eight subunits and a transmembrane ring. The ring has a tetrameric shape with a helix-loop-helix protein...

protein KIAA2013, also known as Q8IYS2 or MGC33867, is a single-pass transmembrane protein encoded by the KIAA2013 gene in humans. The complete function...

Mibefradil Niflumic acid Activators Carbachol CFTRTooltip Cystic fibrosis transmembrane conductance regulator Blockers Glibenclamide Lonidamine Piretanide Activators...

Ascorbate ferrireductase (transmembrane) (EC 1.16.5.1, cytochrome b561) is an enzyme with systematic name Fe(III):ascorbate oxidorectuctase (electron-translocating)...

OmpA-like transmembrane domain is an evolutionarily conserved domain of bacterial outer membrane proteins. This domain consists of an eight-stranded beta...

Transmembrane protein 50A is a protein that in humans is encoded by the TMEM50A gene. This gene is located in the RH gene locus, between the RHD and RHCE...

a type I transmembrane (TM) protein which consists of a leucine-rich repeat (LRR) ectodomain (extracellular domain), a single transmembrane helix, and...

Transmembrane protein 138 is a protein that in humans is encoded by the TMEM138 gene. Transmembrane protein 138 is an integral component of the Tectonic...

The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine...

P24 protein family is a group of transmembrane proteins that are major components of COPI and COPII-coated vesicles. The family is also known as EMP24/GP25L/p24...

Transmembrane protein 171 (TMEM171) is a protein that in humans is encoded by the TMEM171 gene. TMEM171 is also known as PRP2 or proline-rich protein...

of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain...

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the...

predicted to be 444 amino acyl residues in length and exhibits 10 putative transmembrane α-helical segments. The KX blood group antigen mRNA expression pattern...

protein that in humans is encoded by the FAM151A gene. The protein is a transmembrane protein expressed in the kidney tubules, and is an ortholog of menorin...

Transmembrane protein 229b is a protein that in humans is encoded by the TMEM229b gene. The TMEM229B gene is also known as C14orf83, FLJ33387, Q8NBD8...

Mibefradil Niflumic acid Activators Carbachol CFTRTooltip Cystic fibrosis transmembrane conductance regulator Blockers Glibenclamide Lonidamine Piretanide Activators...

domains, then "zips up" through the ligand-binding domain into the transmembrane ion pore. The conformation of the subunit protein in the plasma membrane...

EGFR may refer to: Epidermal growth factor receptor (EGFR), a transmembrane receptor protein in humans Estimated glomerular filtration rate (eGFR), a...

binds to a transmembrane protein. The transmembrane proteins interacts with Gɑβ𝛾. Gαs separates from Gβ𝛾 and interacts with the transmembrane protein adenylyl...

Transmembrane protein 25 is a protein that in humans is encoded by the TMEM25 gene. GRCh38: Ensembl release 89: ENSG00000149582 – Ensembl, May 2017 GRCm38:...

pathogen/host cell interactions. These proteins are related to OmpA-like transmembrane domain family. Vandeputte-Rutten L, Bos MP, Tommassen J, Gros P (July...

Transmembrane 4 L6 family member 1 is a protein that in humans is encoded by the TM4SF1 gene. The protein encoded by this gene is a member of the transmembrane...

main driving force of cross-flow filtration process is transmembrane pressure. Transmembrane pressure is a measure of pressure difference between two...

photoreceptor outer segment ciliary membrane Golgi-associated vesicle membrane transmembrane transporter complex terminal bouton intracellular cyclic nucleotide...

the family are of 256-285 residues in length and exhibit 6-8 putative transmembrane α-helical spanners (TMSs). In one case, that of the E. coli FocA (TC#...

Transmembrane protein 117 is a protein that, in humans, is encoded by the TMEM117 gene. GRCh38: Ensembl release 89: ENSG00000139173 – Ensembl, May 2017...

C5orf15 gene. It can also be referred to as keratinocyte-associated transmembrane protein 2 precursor (KCT2) or HTGN29, but is most commonly referred...

enzyme that in humans is encoded by the HPN gene. Hepsin is a type II transmembrane serine protease found on the cell surface of various mammalian tissues...

also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin)...

(PSCP) Family 1.D.48 The Pore-forming Syringomycin E Family 1.D.49 The Transmembrane Carotenoid Radical Channel (CRC) Family 1.D.50 The Amphiphilic bis-Catechol...

proteins which contain a transmembrane domain, as well as the non-receptor tyrosine kinases which do not possess transmembrane domains. The first RTKs...

membrane, as well as actin connected to the transmembrane. The metric cellular matrix is bound by transmembrane proteins, including the β1-integrin, to the...

porters of other bacteria also lack a IIA domain. BglF consists of a transmembrane domain, which in addition to TMSs, contains a large cytoplasmic loop...

membrane proteins or anchored through a single transmembrane helix. Some others are multi-span transmembrane proteins, for example rhomboid protease. The...

Transmembrane protein 33 is a protein that in humans, is encoded by the TMEM33 gene, also known as SHINC3. Another name for the TMEM33 protein is DB83...

shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2)...

the TSPAN6 gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members...

TMEM50A: Transmembrane protein 50A TMEM59: Transmembrane protein 59 TMEM69: Transmembrane protein 69 TMEM201 encoding protein Transmembrane protein 201...

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a regulator protein that in humans is...

Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene. TMC1 contains six transmembrane domains with both the C...

Transmembrane protease, serine 11B is a protein that in humans is encoded by the TMPRSS11B gene. GRCh38: Ensembl release 89: ENSG00000185873 – Ensembl...

in humans is encoded by the PROM1 gene. It is a member of pentaspan transmembrane glycoproteins, which specifically localize to cellular protrusions....

Transmembrane protein 184B is a protein that in humans is encoded by the TMEM184B gene. GRCh38: Ensembl release 89: ENSG00000198792 – Ensembl, May 2017...

protein which in humans is encoded by the C4orf3 gene. ARLN is a small ER transmembrane protein that regulates calcium homeostasis through SERCA (sarco-endoplasmic...

as orientation, extent of insertion, and hydrophobic mismatch. The transmembrane region of many integral membrane proteins consists of one or more alpha...

TMEM275 (Transmembrane protein 275) is a protein that in humans is encoded by the TMEM275 gene. TMEM275 has two, highly-conserved, helical trans-membrane...

extracellular and transmembrane regions of the CD3γε/CD3δε/CD3ζζ/TCRαβ complex was solved with CryoEM, showing for the first time how the CD3 transmembrane regions...

cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J Biol Chem. 277...

Human concentrative nucleoside transporters include SLC28A1, SLC28A2 and SLC28A3 proteins. SLC28A2 is a purine-specific Na+-nucleoside cotransporter localised...

Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene. This gene encodes a member of the fibronectin...

in length and possess 8 to 12 putative transmembrane α-helical spanners. Members may possess 11 transmembrane segments (TMSs), as seems to be true for...

surrounded by amphipathic α-helices. Some members of the family have transmembrane domains at their c-terminus which primarily function to localize them...

3 open reading frame 5 (C3orf52), also known as TTMP or TPA-Induced Transmembrane Protein (accession: NP_078892), is an uncharacterized protein encoded...

discovered by genomic sequence analysis. Collagen XXIII is a type II transmembrane protein and the fourth in the subfamily of non-fibrillar transmembranous...

been shown to interact with GRID2, BECN1, RHOQ, ACCN3, Cystic fibrosis transmembrane conductance regulator and CSPG5. GRCh38: Ensembl release 89: ENSG00000047932...

Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a transmembrane protein (1009 aa) encoded by the GRID1 gene. A C-terminal GluD1 splicing...

other 5-HT receptors are G-protein-coupled receptors (also called seven-transmembrane, or heptahelical receptors) that activate an intracellular second messenger...

The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor is composed of a membrane-bound immunoglobulin molecule...

their number of transmembrane domains and their endoplasmic reticulum membrane topology. All Class I viroporins contain one transmembrane domain that takes...

lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of...

Lysosomal-associated transmembrane protein 4B is a protein that in humans is encoded by the LAPTM4B gene. LAPTM4B protein contains a lysosome localization...

Protein 19, encodes the SMIM19 protein. SMIM19 is a confirmed single-pass transmembrane protein passing from outside to inside, 5' to 3' respectively. SMIM19...

gene in humans. G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G...

isolate of E. coli. It has 346 amino acyl residues (aas) and 9 putative transmembrane segments (TMSs) with a large hydrophilic loop between TMSs 5 and 6....

of human cells and is encoded by the MCUB gene. While CCDC109B is a transmembrane protein it is unclear if it is located within the cell membrane or mitochondrial...

Transmembrane protein 219 also known as insulin-like growth factor-binding protein 3 receptor or IGFBP-3R is a protein that in humans is encoded by the...

mutations in both copies (alleles) of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Those with a single working copy...

matrix into the intermembrane space, storing energy in the form of a transmembrane electrochemical gradient. The protons move back across the inner membrane...

Zinc transporter ZIP4 is a transmembrane protein which in humans is encoded by the SLC39A4 gene. It is associated with acrodermatitis enteropathica. Solute...

consists of two types of integral proteins, including proteins with transmembrane β-barrel and proteins with one or more α-helical membrane anchors. The...

A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin. The C-type designation is from their requirement for calcium for binding...

hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is...

The Na+ Transporting Mrp Superfamily is a superfamily of integral membrane transport proteins. It includes the TC families: 2.A.63 - The Monovalent Cation...

process regulation of cell size negative regulation of potassium ion transmembrane transport myelination regulation of axon diameter cellular magnesium...

Transmembrane 202 protein (Homo sapiens, TMEM202) is encoded by the gene TMEM202 and is a member of the Claudin2 superfamily. Human paralogs include LIMP2...

proteases (I-CLiPs), are enzymes that have the property of cleaving transmembrane domains of integral membrane proteins. All known intramembrane proteases...

containing over half the mass of the protein. The transmembrane section (M domain) typically has ten transmembrane helices (M1-M10), with the binding sites for...

Transmembrane protein 196 is a protein that in humans is encoded by the TMEM196 gene. GRCh38: Ensembl release 89: ENSG00000173452 – Ensembl, May 2017...

Meiothermus silvanus is 108 amino acyl residues in length and possesses 3 transmembrane segments. Holins Lysins Holin superfamily III Transporter Classification...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

protein does not appear to be post translationally modified and has four transmembrane domains. Both the N-terminus and C-terminus lie on the intracellular...

The SGCE gene encodes the epsilon member of the sarcoglycan family, transmembrane components of the dystrophin-glycoprotein complex, which links the cytoskeleton...

PMID 7656991. "Entrez Gene: SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C". Inagaki...

Flippases are transmembrane lipid transporter proteins located in the cell membrane. They are responsible for aiding the movement of phospholipid molecules...

Chapelle, A.; Sankila, E. M. (2001). "Mutations in a Novel Gene with Transmembrane Domains Underlie Usher Syndrome Type 3". The American Journal of Human...

C-terminal transmembrane domain, a SNARE domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxin 17 may have two transmembrane domains...

exist; one cell surface form that is anchored via glycolipid, and two transmembrane forms. The normal protein is not sedimentable; meaning that it cannot...

between the epidermal cells are of the adherens junction type, formed by transmembrane proteins called cadherins. Inside the cell, the cadherins are linked...

(PSE) Family (TC# 2.A.98) is composed of several putative 10 or 11 transmembrane segment (TMS) proteins. This family is part of the CPA superfamily and...

tissue development, intracellular zinc ion homeostasis, and zinc ion transmembrane transport. SLC39A13 has multiple transcript variants listed in NCBI...

the binding capacity of the disintegrin domain. The transmembrane helix is a single-pass transmembrane segment that anchors ADAM20 to the sperm plasma membrane...

composed of a cytosolic, V1, (site of the ATP catalytic site) and a transmembrane, V0, domain. V-ATPase dependent organelle acidification is necessary...

GABAAR subunit-interface transmembrane locations. High anesthetic dosages of ethanol act on GABAAR subtype-dependent transmembrane domain locations. Ethanol...

and 549 amino acyl residues in length and are predicted to have 8-12 transmembrane α-helical spanners. The E. coli homologue of 412 aas exhibits 11 putative...

Fat storage-inducing transmembrane protein 1 is a protein that in humans is encoded by the FITM1 gene. FIT1 belongs to an evolutionarily conserved family...

(December 2000). "Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor". Journal of Neurochemistry...

single transmembrane helix. List of EC numbers of enzymes belonging to category EC 4 "Lyase". www.uniprot.org. Superfamilies of single-pass transmembrane lyases...

describes the ionic flux across a cell membrane as a function of the transmembrane potential and the concentrations of the ion inside and outside of the...

domain-containing protein 4 TMBIM1: Transmembrane BAX inhibitor motif-containing protein 1 TMEM182: encoding protein Transmembrane protein 182 TNRC15: PERQ amino...

glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based...

Sushi domain is an evolutionarily conserved protein domain. It is also known as complement control protein (CCP) modules or short consensus repeats (SCR)...

King SA, et al. (1998). "The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the...

identified as Kirsten ras associated gene (KRAG), sarcospan is a 25-kDa transmembrane protein located in the dystrophin-associated protein complex of skeletal...

ligand-gated ion channels. Like GPCRs, insect ORs are transmembrane proteins with seven transmembrane helices, but with a reversed topology, with an intracellular...

action potentials are initiated by voltage-gated sodium channels. As the transmembrane voltage is increased the probability that a given voltage gated sodium...

V-domain Ig suppressor of T cell activation (VISTA) is a type I transmembrane protein that functions as an immune checkpoint and is encoded by the VSIR...

consists of the characteristic four homologous I–IV domains containing six transmembrane α-helices each. The α1 subunit forms the Ca2+ selective pore, which...

Transport and Golgi organization protein 6 homolog also known as transmembrane and coiled-coil domain-containing protein 7 is a protein that in humans...

Ichthyin, is a gene that is predicted to code for a transmembrane protein with nine transmembrane domains. NIPAL4 codes for the protein magnesium transporter...

the UPK1A gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members...

exchange of protons and potassium ions.[citation needed] The combined transmembrane gradient of protons and charges created by proton pumps is called an...

130 to 210 amino acyl residues (aas) in length and may exhibit 1 or 2 transmembrane segments (TMSs). A representative list of proteins belonging to the...

Molecular function antiporter activity secondary active transmembrane transporter activity transmembrane transporter activity Cellular component membrane mitochondrion...

ubiquitin-dependent protein catabolic process negative regulation of ion transmembrane transport Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA:...

phosphotransferase system. All of these proteins possess twelve putative transmembrane α-helical spanners. Homologues are from bacteria, including the distantly...

of congenital diaphragmatic hernia Luteinizing hormone receptor, a transmembrane receptor in reproductive tissues Light Horse Regiment, former name of...

Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential...

homologous repeat domains (I-IV) each comprising six transmembrane segments (S1-S6) for a total of 24 transmembrane segments. The members of this family also coassemble...

electrochemical potential of that reaction.[citation needed] The generation of a transmembrane electrical potential through ion movement across a cell membrane drives...

pancreatic ducts as well as many other secretory epithelia. Cystic fibrosis transmembrane conductance regulator (CFTR) is the mutated gene and is essential to...

membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

membranes via a C-terminal transmembrane domain. Seven of the 38 known SNAREs, including SNAP-25, do not have a transmembrane domain and are instead attached...

comes from the Greek 'piesi,' meaning 'pressure.' Piezos are large transmembrane proteins conserved among various species, but they don't have known...

humans is encoded by the NIPA1 gene. This gene encodes a potential transmembrane protein which functions either as a receptor or transporter molecule...

homologue, RcnA (YohM; TC# 2.A.113.1.1) of E. coli (274 aas) has 6 putative transmembrane segments (TMSs) in a 3 + 3 arrangement with a large hydrophilic loop...

acts specifically as a selective negative allosteric modulator of the transmembrane AMPA receptor regulatory protein (TARP) γ-8 and potently and selectively...

The monocarboxylate transporters, or MCTs, are a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group...

These receptors are G-protein-coupled receptors, which contain seven transmembrane portions, intracellular loops, extracellular loops, intracellular C-terminus...

ion transmembrane transport regulation of membrane potential potassium ion transmembrane transport potassium ion transport ion transport transmembrane transport...

Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene. FLRT1, FLRT2 and FLRT3 are members of the fibronectin...

Chemokine-like factor (CKLF) is a member of the CKLF-like MARVEL transmembrane domain-containing family of proteins that in humans is encoded by the CKLF...

import across plasma membrane potassium ion transmembrane transport transmembrane transport anion transmembrane transport Sources:Amigo / QuickGO Orthologs...

TMEM128, also known as Transmembrane Protein 128, is a protein that in humans is encoded by the TMEM128 gene. TMEM128 has three variants, varying in 5'...

propeller-shaped architecture. Each subunit of PIEZO1 contains between 30 and 40 transmembrane domains. The protein consists of a central pore module and peripheral...

III adenylyl cyclases are transmembrane proteins with 12 transmembrane segments. The protein is organized with 6 transmembrane segments, then the C1 cytoplasmic...

BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, PED, SHEP1, OCA2 melanosomal transmembrane protein, P External IDs OMIM: 611409; MGI: 97454; GeneCards: OCA2 Gene...

encoded by the PAG1 gene. The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is...

also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+...

humans is encoded by the SORL1 gene. SORLA, is a 2214 residue type I transmembrane protein. SORLA a is receptor that binds certain peptides and integral...

binding transmembrane transporter activity GTPase activator activity xenobiotic transmembrane transporter activity ATPase-coupled transmembrane transporter...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

Anoctamin-1 (ANO1), also known as Transmembrane member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-gated...

Secreted and transmembrane protein 1 is a protein that in humans is encoded by the SECTM1 gene. This gene encodes a transmembrane and secreted protein...

categories;signalling proteins. Scaffolding proteins – organise the transmembrane proteins, couple transmembrane proteins to other cytoplasmic proteins as well as to...

Not much is reported about the protein, but it is predicted to be a transmembrane protein. The protein contains the domain of unknown function 4605 (DUF4605)...

factor receptors (sTNFR) are the cleaved-off extracellular domains of transmembrane TNF receptors. They are proposed to enter the bloodstream either via...

Transmembrane protein 42 (TMEM42) is a protein which in humans is encoded by the TMEM42 gene. TMEM42 and its associated proteins may play a role in development...

C4-dicarboxylate uptake family or Dcu family (TC# 2.A.13) is a family of transmembrane ion transporters found in bacteria. Their function is to exchange dicarboxylates...

Transmembrane protein 53, or TMEM53, is a protein that is encoded on chromosome 1 in humans. It has no paralogs but is predicted to have many orthologs...

gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

membrane-bound proteins are targeted to the secretory pathway by their first transmembrane domain, which biochemically resembles a signal sequence except that...

impulses to pass between the two cells. These complexes, consisting of transmembrane adhesion proteins of the cadherin family, link adjacent cells together...

lungs or intestine. Next to their physical properties, gel-forming and transmembrane mucins alike are also involved in cell signalling and immune responses...

Transmembrane protein 106B is a protein that is encoded by the TMEM106B gene. It is found primarily within neurons and oligodendrocytes in the central...

junctions. These proteins consist of both transmembrane and cytoplasmic proteins. The three major transmembrane proteins are occludin, claudins, and junction...

member, membral, membrane, membranous, nonmember, semimembranous, transmembrane memor memor- mindful commemorate, commemoration, commemorative, immemorial...

Biological process anion transmembrane transport ion transport regulation of anion transport signal transduction transmembrane transport transport cell...

B. firmus is 462 amino acyl residues long and possesses 12 putative transmembrane α-helical segments. MleN of B. subtilis (468 aas; TC# 2.A.35.1.2) also...

Mibefradil Niflumic acid Activators Carbachol CFTRTooltip Cystic fibrosis transmembrane conductance regulator Blockers Glibenclamide Lonidamine Piretanide Activators...

DUF3496 remains the most likely. This protein may play a role as a transmembrane protein. For humans, this gene is located on chromosome 9q12 (67977457...

Kobayashi K, Satoh N (2005). "Ci-Rga, a gene encoding an MtN3/saliva family transmembrane protein, is essential for tissue differentiation during embryogenesis...

ADAM12-L, the long form, has a transmembrane region and ADAM12-S, a shorter variant, is soluble and lacks the transmembrane and cytoplasmic domains. This...

providing the neural receptor for migration in astro-gial membranes via its transmembrane regions to intersect glial membranes. Using phase-contrast microscopy...

proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. doi:10...

factors in causing the autosomal dominant Crouzon syndrome. These two transmembrane proteins are two of four fibroblast growth factor receptors involved...

b6f ← phylloquinone PSI, like PSII, is a complex, highly organized transmembrane structure that contains antenna chlorophylls, a reaction center (P700)...

CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. CD34 derives its name from the cluster...

Specific transmembrane protein complexes called Branched Chain Amino Acid Exporters (LIV-E) mediate the export of branched chain amino acids out of prokaryotic...

Example Respiratory enzymes anoxic, oxic Fumarate reductase (frdABCD) Transmembrane carriers Nitrite efflux (narK ) Anaerobic catabolism fermentation Pyruvate...

reference expression data BioGPS n/a Gene ontology Molecular function transmembrane transporter binding Cellular component integral component of membrane...

TRPs, the melastatin or long TRPs, ankyrin (whose only member is the transmembrane protein 1 [TRPA1]) TRPN after the nonmechanoreceptor potential C (nonpC)...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

membranes as peripheral membrane proteins or anchored through a single transmembrane helix, for example certain ubiquitin ligase related proteins. The word...

who are homozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the defective protein that causes...

advanced glycation end-products), also called AGER, is a 35 kilodalton transmembrane receptor of the immunoglobulin super family which was first characterized...

process anion transmembrane transport ion transport fat cell differentiation regulation of anion transport signal transduction transmembrane transport transport...

process regulation of ion transmembrane transport chloride transport ion transport signal transduction chloride transmembrane transport glutathione metabolic...

XK Related 7 (XKR7) is a protein predicted to be a transmembrane protein in Homo sapiens encoded by the XKR7 gene. The primary alias is c20orf159, but...

Fat storage-inducing transmembrane protein 2 is a protein that in humans is encoded by the FITM2 gene. It plays a role in fat storage. Its location is...

the CD37 gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members...

EVA1C (Eva-1 Homolog C) is a transmembrane protein in humans (Homo sapiens) that is encoded by the EVA1C gene on chromosome 21. The EVA1C protein is thought...

phage P68 that is 92 amino acyl residues (aas) in length and exhibits 2 transmembrane segments (TMSs). While annotated as a holin, this protein has not been...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

P24 capsid protein, a protein of HIV P24 protein family, a group of transmembrane proteins Pseudomonas sRNA P24 Maltese patrol boat P24, of the Armed...

ATP binding ATPase-coupled inorganic anion transmembrane transporter activity ATPase-coupled transmembrane transporter activity Cellular component integral...

sequence specifying the transmembrane domain of HER2. Substitution of a valine for a glutamic acid or a glutamine in the transmembrane domain can result in...

Biological process ion transport transmembrane transport lactate metabolic process mitochondrial magnesium ion transmembrane transport magnesium ion transport...

holin; TC# 1.E.45.1.1) of 64 amino acyl residues (aas) in length with 2 transmembrane segments (TMSs). It is a putative uncharacterized protein from Xanthomonas...

(VEGF), and platelet-derived growth factor (PDGF) are all recognized by transmembrane proteins called RTKs. Additionally, they can function as receptors for...

of the polycystin protein family, called TRPP, and contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral...

membrane of E. coli bacteria most likely via a predicted N-terminal transmembrane domain helix. However, it has become apparent that H protein is a multifunctional...

protein that in humans is encoded by the SLCO1B3 gene. OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter...

antibody-drug conjugate (ADC) that targets cancer cells expressing transmembrane glycoprotein NMB (GPNMB). In May 2010, the U.S FDA granted Fast Track...

Transmembrane protein 169 (TMEM169) in humans is encoded by TMEM169 gene. The aliases of TMEM169 include FLJ34263, DKFZp781L2456, and LOC92691. TMEM169...

330 kb downstream of the SIGLEC9 gene. Within the siglec family of transmembrane proteins, Siglec-8 belongs to the CD33-related siglec subfamily, a subfamily...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

latrunculin. In 2011 he and his colleagues presented strong evidence of transmembrane adenyl cyclase being present in Rhinella arenarum. In 1999, Visconti...

Transmembrane protein 248, also known as C7orf42, is a gene that in humans encodes the TMEM248 protein. This gene contains multiple transmembrane domains...

ERx is a putative membrane estrogen receptor (mER) of which little is currently known. It was discovered as a gene transcription signature induced by estradiol...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

alpha-helical transmembrane segments, M1 and M2, which are interconnected by an extracellular loop. It forms a homopentameric channel with ten transmembrane spanners...

Transmembrane protein 216 is a protein in humans that is encoded by the TMEM216 gene. Mutations in this gene may be associated with Meckel syndrome or...

for a disintegrin and metalloproteinase) are a family of single-pass transmembrane and secreted metalloendopeptidases. All ADAMs are characterized by a...

IV membrane integral component of membrane Biological process proton transmembrane transport electron transport chain response to bacterium Sources:Amigo...

function glucose transmembrane transporter activity Cellular component membrane integral component of membrane Biological process transmembrane transport glucose...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and...

Biochemistry in Germany. It is used to optically measure the changes in transmembrane voltage of excitable cells, including neurons, skeletal and cardiac...

cholinergic synapse serotonergic synapse Biological process ion transport transmembrane transport sodium ion transport bile acid and bile salt transport adult...

The Peptidoglycolipid Addressing Protein (GAP) Family is a member of the Lysine Exporter (LysE) Superfamily. It is listed as item 2.A.116 in the Transporter...

agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor. A genome wide CRISPR/Cas9...

Cation diffusion facilitators (CDFs) are transmembrane proteins that provide tolerance of cells to divalent metal ions, such as cadmium, zinc, and cobalt...

Telemedicine Transcendental Meditation, a form of silent, mantra meditation Transmembrane emp24 domain-containing protein, protein found in humans such as TMED1...

(PRRG2 or TMG2, PRGP2, O14669) Transmembrane γ-carboxy glutamyl protein 3 (PRRG3 or TMG3, PRGP3; Q9BZD7) Transmembrane γ-carboxy glutamyl protein 4 (PRRG4...

many influences. Involved in these processes are, among others, the transmembrane proteins occludin, claudins, tight junction protein ZO-1, cadherins...

after sequential cleavage of the amyloid precursor protein (APP), a transmembrane glycoprotein of undetermined function. APP can be cleaved by the proteolytic...

that in humans is encoded by the M6PR gene. The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate (M6P) tags on acid hydrolase...

reference expression data Gene ontology Molecular function protein transmembrane transporter activity ribonuclease activity protein binding Cellular...

also a constituent of the protein complex required for insertion of transmembrane beta-barrel proteins into the lipid bilayer. However, a homologue of...

Lck-interacting transmembrane adapter 1 is a protein that in humans is encoded by the LIME1 gene. LIME1 is a raft-associated transmembrane adaptor phosphoprotein...

conclusively identified but is believed to be a metalloproteinase. BACE is a transmembrane protein with an extracellular aspartic acid protease domain. γ-secretase...

receptor, is a protein that in humans is encoded by the PVR gene. It is a transmembrane protein that is involved in forming junctions between neighboring cells...

(cysteine-rich) domain that links the VFT to the 7 transmembrane domains of the receptor. The 7 transmembrane domain is followed by a long cytoplasmatic tail...

that forms high affinity, stable complexes with both the soluble and transmembrane bioactive forms of human TNF-a, which prevents the binding of TNF-a...

Transmembrane and Tetratricopeptide repeat containing 4 is a protein that in humans is encoded by the TMTC4 gene. This protein crosses the plasma membrane...

following sizes (in #aas) and exhibit the following putative numbers of transmembrane α-helical spanners (TMSs): PhaA - 725 and 17 PhaB - 257 and 5 PhaC -...

sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing...

several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent...

facilitated diffusion. This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues. Glucose...

Rich And Transmembrane Domain Containing 2, is a protein which in humans is encoded by the SERTM2 gene. The SERTM2 protein is a transmembrane protein located...

Vacuolar protein sorting proteins are involved in the intracellular sorting and delivery of soluble vacuolar proteins. Kolesnikova L, Strecker T, Morita...

cytoplasm nucleus Biological process response to osmotic stress ion transmembrane transport regulation of transcription, DNA-templated negative regulation...

protein superfamily of integral membrane proteins, usually of 7 or 8 transmembrane alpha-helical segments (TMSs). It includes (1) ion-translocating microbial...

Molecular function symporter activity L-glutamate transmembrane transporter activity neurotransmitter transmembrane transporter activity Cellular component integral...

(TRIC-B) is a monovalent cation channel in the ER membrane encoded by the transmembrane protein 38B (TMEM38B) gene. It is one of two known TRIC proteins, the...

of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with...

or simply delta receptor, abbreviated DOR or DOP, is an inhibitory 7-transmembrane G-protein coupled receptor coupled to the G protein Gi/G0 and has enkephalins...

gene. It is localized in the mitochondrial outer membrane and has four transmembrane domains. The human gene MARCH5, also known as MITOL or RNF153, has 7...

(CNS). Barbiturates bind to the GABAA receptor at multiple homologous transmembrane pockets located at subunit interfaces, which are binding sites distinct...

Cleft lip and palate transmembrane protein 1 (Clptm1) is a multi-transmembrane protein that in humans is encoded by the CLPTM1 gene. Clptm1 was characterized...

involved in the fly circadian clock TIM barrel, a protein fold structure Transmembrane immunoglobulin and munin domain, a family of immunomodulatory proteins...

Transmembrane protein 39B (TMEM39B) is a protein that in humans is encoded by the gene TMEM39B. TMEM39B is a multi-pass membrane protein with eight transmembrane...

into the circulating form. The KL gene encodes a type-I single-pass transmembrane protein that is related to β-glucuronidases. Reduced production of this...

Transmembrane and coiled-coil domains 5A is a protein that in humans is encoded by the TMCO5A gene. GRCh38: Ensembl release 89: ENSG00000166069 – Ensembl...

Mycobacterial porins are a group of transmembrane beta-barrel proteins produced by mycobacteria, which allow hydrophilic nutrients to enter the bacterium...

et al.'s method for TM region allocation indicates potential for two transmembrane proteins with a high likelihood of the protein also being peripheral...

transport) of molecules or ions across a biological membrane via specific transmembrane integral proteins. Being passive, facilitated transport does not directly...

and other bacteria. They are integral membrane proteins with seven transmembrane helices, the last of which contains the attachment point (a conserved...

EA (1996). "HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor". Science. 272 (5263): 872–7. Bibcode:1996Sci...

Mibefradil Niflumic acid Activators Carbachol CFTRTooltip Cystic fibrosis transmembrane conductance regulator Blockers Glibenclamide Lonidamine Piretanide Activators...

Robert Krane also played a prominent role in this field. Specialized transmembrane proteins recognize the substance and allow it to move across the membrane...

SANS Scaffold protein 461 Q495M9 606943 USH2A 80% 1q41 USH2A Usherin Transmembrane linkage 5202 O75445 276901 USH2C 15% 5q14.3-q21.1 GPR98 VLGR1b Very...

protein that in humans is encoded by the EDA gene. Ectodysplasin A is a transmembrane protein of the TNF family which plays an important role in the development...

al. (2013) Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels. 2012 Chan...

Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein belonging to a family of keratan sulfate proteoglycans, located on the synaptic vesicles...

potassium ion transmembrane transporter activity regulation of inflammatory response negative regulation of potassium ion transmembrane transport negative...

(September 2006). "The HAMP domain structure implies helix rotation in transmembrane signaling". Cell. 126 (5): 929–40. doi:10.1016/j.cell.2006.06.058. PMID 16959572...

Wiktionary, the free dictionary. Porin may refer to: Porin (protein), a transmembrane protein Porin (opera), a Croatian grand opera, first performed in 1897...

The follicle-stimulating hormone receptor or FSH receptor (FSHR) is a transmembrane receptor that interacts with the follicle-stimulating hormone (FSH)...

the TSPAN31 gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members...

CKLF like MARVEL transmembrane domain-containing 8 (i.e. CMTM8), previously termed chemokine-like factor superfamily 8 (i.e. CKLFSF8) has at least two...

transmembrane 7 superfamily member 2 TMEM109: encoding protein Transmembrane protein 109 TMEM123: transmembrane protein 123 TMEM126B: transmembrane protein...

and they cleave other transmembrane proteins within their transmembrane domains. About 30% of all proteins have transmembrane domains, and their regulated...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and...

PMID 10642437. S2CID 6529349. "Entrez Gene: CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)". Phua YL, Martel N, Pennisi DJ, Little...

composition of these subunits affects the range of specificity for VRACs. The transmembrane portion of LRRC8 proteins are similar to those in Pannexins. LRRC8A...

fingers, commonly called knuckles Methyl-accepting chemotaxis protein, a transmembrane sensor protein of bacteria Modified citrus pectin, a form of pectin...

expression data BioGPS n/a Gene ontology Molecular function ATPase-coupled transmembrane transporter activity nucleotide binding ABC-type bile acid transporter...

of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with...

Epstein–Barr virus. LMP2A/LMP2B are transmembrane proteins that act to block tyrosine kinase signaling. LMP2A is a transmembrane protein that inhibits normal...

BioGPS More reference expression data Gene ontology Molecular function transmembrane transporter binding dioxygenase activity structural molecule activity...

the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor...

present in most multicellular organisms Notch proteins, a family of transmembrane proteins Notch filter, a band-stop filter with a narrow stopband Notch...

American roller derby league lutropin/choriogonadotropin receptor, a transmembrane receptor This disambiguation page lists articles associated with the...

Store-operated calcium entry-associated regulatory factor, also known as transmembrane protein 66 (TMEM66) is a protein that in humans is encoded by the SARAF...

kDa transmembrane glycoprotein, which includes 10–15 kDa of N-terminal glycosylation. The N-terminal half of the protein contains six transmembrane helixes...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

across species.Focusing on the transmembrane regions, mutagenesis-driven affinity studies have revealed the second transmembrane region as the determinant...

efflux pump. AbgT is 510 amino acyl residues long and has 12-13 putative transmembrane α-helical spanners (TMSs). MtrF is 522 aas long and has 11 or 12 putative...

hydrophobic regions in the protein sequence, there have been no confirmed transmembrane domains present A protein kinase C phosphorylation site is predicted...

and many hormones act by binding specifically to their receptors. Transmembrane proteins can serve as ligand transport proteins that alter the permeability...

the α-subunit is of 340 amino acyl residues (aas) with 7 putative transmembrane segments (TMSs) while the β-subunit is of 128 aas with 1 putative TMS...

humans is encoded by the ANO6 gene. This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential...

Gene ontology Molecular function neuroligin family protein binding transmembrane signaling receptor activity cell adhesion molecule binding calcium channel...

Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the TMUB2 gene. TMUB2 maps on the human chromosome...

antimicrobial peptides frequently destabilize biological membranes, can form transmembrane channels, and may also have the ability to enhance immunity by functioning...

Biological process chloride transport chloride transmembrane transport ion transport ion transmembrane transport Sources:Amigo / QuickGO Orthologs Databases...

Franzke CW, Bruckner P, Bruckner-Tuderman L (February 2005). "Collagenous transmembrane proteins: recent insights into biology and pathology". Journal of Biological...

are usually 500-600 amino acyl residues long and possess 12 putative transmembrane α-helical segments (TMSs). Residues in the first TMS and in the region...

encoded by the TMEM267 gene. It is a possible oncogene which encodes a transmembrane protein. The function of TMEM267 most likely involves transportation...

and growth delay, and Homo Sapiens leucine zipper-EF-hand containing transmembrane protein 1 (LETM1), which is associated with seizures. About 87% of cases...

B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19. In humans, CD19...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

individuals identified variants of the gene KLB, which encodes the transmembrane protein β-Klotho, as highly associated with alcohol consumption. The...

cysteine rich extracellular domain from AA1 to AA138 (Amino Acid), a transmembrane region from AA139 to AA159, C-terminus region with a proline rich region...

endoplasmic reticulum stress endoplasmic reticulum mannose trimming transmembrane transport ubiquitin-dependent protein catabolic process retrograde protein...

arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and...

general bioenergetic principle: the conservation of energy through transmembrane electrochemical gradients. The synthesis of ATP by ATP synthase, driven...