ADAM23

ADAM23
Identifiers
Aliases	ADAM23, MDC-3, MDC3, ADAM metallopeptidase domain 23
External IDs	OMIM: 603710; MGI: 1345162; HomoloGene: 2826; GeneCards: ADAM23; OMA:ADAM23 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	206,621,127 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	63,635,435 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; middle temporal gyrus; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; primary visual cortex; ; postcentral gyrus; ; superior frontal gyrus; ; Brodmann area 9; ; left ventricle; ; nucleus accumbens;
	Top expressed in
	facial motor nucleus; ; superior frontal gyrus; ; substantia nigra; ; cerebellar cortex; ; anterior horn of spinal cord; ; pontine nuclei; ; supraoptic nucleus; ; primary visual cortex; ; medial vestibular nucleus; ; deep cerebellar nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding; metalloendopeptidase activity; protein binding; metallopeptidase activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; membrane; glutamatergic synapse; integral component of presynaptic membrane;
Biological process	central nervous system development; cell adhesion; proteolysis; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	8745
	23792
	ENSG00000114948
	ENSMUSG00000025964
	O75077
	Q9R1V7
	NM_003812
	NM_001177600; NM_011780
	NP_003803
	NP_035910
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 23 is a non-catalytic protein that in humans is encoded by the ADAM23 gene.^[5]^[6] It is a member of the ADAM family of extracellular matrix metalloproteinases.

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114948 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025964 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sagane K, Ohya Y, Hasegawa Y, Tanaka I (Aug 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.
^ ^a ^b "Entrez Gene: ADAM23 ADAM metallopeptidase domain 23".

External links

The MEROPS online database for peptidases and their inhibitors: M12.979
Human ADAM23 genome location and ADAM23 gene details page in the UCSC Genome Browser.