ADAMTS8

ADAMTS8
Identifiers
Aliases	ADAMTS8, ADAM-TS8, METH2, ADAM metallopeptidase with thrombospondin type 1 motif 8
External IDs	OMIM: 605175; MGI: 1353468; HomoloGene: 5108; GeneCards: ADAMTS8; OMA:ADAMTS8 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	130,428,609 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	30,875,134 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; upper lobe of left lung; ; endothelial cell; ; lower lobe of lung; ; right lung; ; Brodmann area 23; ; entorhinal cortex; ; tail of epididymis; ; right coronary artery; ; visceral pleura;
	Top expressed in
	tunica media of zone of aorta; ; lumbar spinal ganglion; ; soleus muscle; ; ankle; ; atrium; ; internal carotid artery; ; endocardial cushion; ; semi-lunar valve; ; inner muscle layer; ; tunica adventitia of aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	integrin binding; zinc ion binding; peptidase activity; metalloendopeptidase activity; heparin binding; low-affinity phosphate transmembrane transporter activity; metallopeptidase activity; hydrolase activity; metal ion binding;
Cellular component	extracellular region; extracellular matrix; collagen-containing extracellular matrix;
Biological process	proteolysis; negative regulation of cell population proliferation; phosphate ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	11095
	30806
	ENSG00000134917
	ENSMUSG00000031994
	Q9UP79
	P57110
	NM_007037
	NM_013906; NM_001326292
	NP_008968
	NP_038934.2
	Wikidata
View/Edit Human	View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.^[5]^[6]

Function

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo.^[6]

Clinical significance

A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134917 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031994 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (Sep 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.
^ ^a ^b ^c "Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8".

External links

The MEROPS online database for peptidases and their inhibitors: M12.226
Human ADAMTS8 genome location and ADAMTS8 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.