ADAMTS10

ADAMTS10
Identifiers
Aliases	ADAMTS10, ADAM-TS10, ADAMTS-10, WMS, WMS1, ADAM metallopeptidase with thrombospondin type 1 motif 10
External IDs	OMIM: 608990; MGI: 2449112; HomoloGene: 81940; GeneCards: ADAMTS10; OMA:ADAMTS10 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	8,610,735 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	33,772,756 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; right coronary artery; ; skin of arm; ; ascending aorta; ; nasal epithelium; ; myocardium of left ventricle; ; granulocyte; ; cardiac muscle tissue of right atrium; ; cerebellar vermis; ; vena cava;
	Top expressed in
	ascending aorta; ; aortic valve; ; granulocyte; ; left lung; ; left lung lobe; ; tail of embryo; ; external carotid artery; ; internal carotid artery; ; genital tubercle; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; metalloendopeptidase activity; protein binding; hydrolase activity; metallopeptidase activity; metal ion binding; molecular function;
Cellular component	microfibril; extracellular region; extracellular matrix; collagen-containing extracellular matrix;
Biological process	proteolysis; biological process;
	Sources:Amigo / QuickGO
Orthologs
	81794
	224697
	ENSG00000142303
	ENSMUSG00000024299
	Q9H324
	P58459
	NM_001282352; NM_030957
NM_172619; NM_001329143; NM_001329147; NM_001329151; NM_001329152;
	NM_001329153; NM_001329154; NM_001329202; NM_001329203
	NP_001269281; NP_112219
NP_001316072; NP_001316076; NP_001316080; NP_001316081; NP_001316082;
	NP_001316083; NP_001316131; NP_001316132; NP_766207
	Wikidata
View/Edit Human	View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.^[5]

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.^[5]