EIF1AY
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene .[ 5] [ 6]
Like its X-chromosomal counterpart EIF1AX , it encodes an isoform of eukaryotic translation initiation factor 1A (EIF1A). EIF1A is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA . It has one amino acid difference (M50L) from EIF1AX.[ 6]
References
Further reading
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution" . PLOS Biol . 2 (7): E207. doi :10.1371/journal.pbio.0020207 PMC 449870 PMID 15252450 . Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches" . Mol. Biol. Evol . 21 (2): 384–96. doi :10.1093/molbev/msh027 PMID 14660691 . Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes" . Nature . 423 (6942): 825–37. Bibcode :2003Natur.423..825S . doi :10.1038/nature01722 PMID 12815422 . Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: A new interaction between old partners" . Proc. Natl. Acad. Sci. U.S.A . 100 (4): 1535–40. Bibcode :2003PNAS..100.1535M . doi :10.1073/pnas.0437845100 PMC 149867 PMID 12569173 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 .
