EIF4E2

EIF4E2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JGB, 2JGC
Identifiers
Aliases	EIF4E2, 4E-LP, 4EHP, EIF4EL3, IF4e, eukaryotic translation initiation factor 4E family member 2, h4EHP
External IDs	OMIM: 605895; MGI: 1914440; HomoloGene: 128466; GeneCards: EIF4E2; OMA:EIF4E2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	232,583,644 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,168,210 bp
RNA expression pattern
	Top expressed in
	monocyte; ; sural nerve; ; Achilles tendon; ; gastrocnemius muscle; ; rectum; ; gingival epithelium; ; mucosa of transverse colon; ; muscle of thigh; ; islet of Langerhans; ; amniotic fluid;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; fossa; ; condyle; ; yolk sac; ; primitive streak; ; seminal vesicula; ; endothelial cell of lymphatic vessel; ; Paneth cell; ; vas deferens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA cap binding; translation factor activity, RNA binding; protein binding; translation initiation factor activity; ubiquitin protein ligase binding; RNA binding; RNA 7-methylguanosine cap binding;
Cellular component	cytoplasm; cytosol; mRNA cap binding complex; eukaryotic translation initiation factor 4F complex;
Biological process	translational initiation; negative regulation of translation; in utero embryonic development; protein biosynthesis; regulation of translation;
	Sources:Amigo / QuickGO
Orthologs
	9470
	26987
	ENSG00000135930
	ENSMUSG00000026254
	O60573
	Q8BMB3
NM_001276336; NM_001276337; NM_001282958; NM_004846; NM_001330201;
	NM_001330202; NM_001330203
	NM_001039169; NM_001039170; NM_023314; NM_001347083
NP_001263265; NP_001263266; NP_001269887; NP_001317130; NP_001317131;
	NP_001317132; NP_004837
	NP_001034258; NP_001034259; NP_001334012; NP_075803
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene.^[5]^[6]^[7]^[8] It belongs to the eukaryotic translation initiation factor 4E family.

Interactions

EIF4E2 has been shown to interact with ARIH1.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135930 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026254 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, et al. (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–8180. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
^ Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, et al. (May 1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein". The Journal of Biological Chemistry. 273 (21): 13104–13109. doi:10.1074/jbc.273.21.13104. PMID 9582349.
^ "Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2".
^ Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, et al. (September 2012). "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development". Molecular and Cellular Biology. 32 (17): 3585–3593. doi:10.1128/MCB.00455-12. PMC 3422012. PMID 22751931.
^ Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Letters. 554 (3): 501–504. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119. S2CID 25441190.

External links

Overview of all the structural information available in the PDB for UniProt: O60573 (Eukaryotic translation initiation factor 4E type 2) at the PDBe-KB.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135930 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026254 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9653160-5] Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, et al. (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–8180. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.

[pmid9582349-6] Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, et al. (May 1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein". The Journal of Biological Chemistry. 273 (21): 13104–13109. doi:10.1074/jbc.273.21.13104. PMID 9582349.

[entrez-7] "Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2".

[8] Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, et al. (September 2012). "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development". Molecular and Cellular Biology. 32 (17): 3585–3593. doi:10.1128/MCB.00455-12. PMC 3422012. PMID 22751931.

[pmid14623119-9] Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Letters. 554 (3): 501–504. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119. S2CID 25441190.

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EIF4E2

Interactions

References

Further reading

External links

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