Marlee and the Design Team builds a new home while Llanes going to Walt Disney World in Orlando, Florida ^{[n 1]}

Due to being unavailable to film this episode, Ty's hosting duties were filled in by Marlee Matlin and her interpreter Jack.

Design team: Marlee, Michael, Paul, Tanya, Paige, Eduardo, Ed, Daniel

Ty and the design team embark on a mission to help a needy family in each of the 50 states, first heading up to North Pole, Alaska to build a new home for a family of thirteen, A single mother and her eight children. Her brother and his three children are living with her so he can be closer to necessary medical treatment. The design team replaced their decaying, rundown, 900sq. ft house (which had only one bathroom) with a large, comfortable home with space for the whole family-and a football field.^{[n 1][n 2]}

Ty's Secret Room: A small classroom in the house
Design Team: Ty, Ed, Michael, Paige, Paul and Preston
Guest Stars: Matt Hasselbeck, Shaun Alexander, Lofa Tutupu

Ty and the design team arrive in Armada, Michigan to remodel the home for a widow and her six children because they had to move out due to a mold infestation that had killed her husband.^{[n 3]}

Ty's Secret Room: Abigale's room (it was not explained that it was the secret project until after Maryann saw her bedroom, in the final part of the episode)

The design team is in Hendersonville, Tennessee to rebuild a family's home and make it wheelchair accessible for mom Amy, who became paralyzed while saving her children during a tornado on April 7, 2006.

Ty's Secret Room: Amy & Jerrod's master bedroom
Design Team: Ed, Paul, Preston, Tracy, and Ty.

Ty and the design team arrive in Minot, North Dakota to rebuild the Bliven family's home to accommodate their son, who has cerebral palsy.

Ty's Secret Room: Bill & Michelle's master bedroom
Design Team: Eduardo, John, Paige, Paul, and Ty.
Guest Star: Tim McGraw.

The design team arrives in Gladbrook, Iowa to rebuild the family's farmhouse after it burned down days before Christmas in 2005.

Ty's Secret Room: office for Kibe dairies

Ty and the gang head to Toronto, South Dakota to help a family whose only daughter has already had four open-heart surgeries in twelve years.

Ty's Secret Room: Siehera's guitar-themed room
Design Team: Michael, Tanya, John, Eduardo and Ty

The design team goes to Indiana to repair a 135-year-old farmhouse for a family whose matriarch is recovering from breast cancer.

Ty's Secret Room: Steve & Shawna's master bedroom

Ty and the design team head to Dundee, Wisconsin to help a family that recently lost their father to skin cancer.^{[n 4]}

Ty's Secret Room: The family room with pictures of the father and the family

Ty and the design team head to Logan, Utah to help a family (immigrants from Tonga) that lost their father to a heart attack. In addition to a new house, the family (which operated a catering and entertainment business featuring Tongan culture and cuisine) received a new catering truck.

Ty's Secret Room: The family catering business kitchen. (In a departure from the norm, where no one gets to see the Secret Room prior to reveal, Ty allowed the local health inspector into the room so the business could obtain the needed operating permit.)

Ty and the design team go to Redondo Beach, California to help a cop mother who was shot in the line of duty and left paralyzed from the waist down. This project was managed by Cornerstone Construction Group with help from Sharefest and 3000 volunteers.^{[n 5][n 1]}

Ty's Secret Room: Tim and Kristina's master bedroom

Ty and the design team head to Lincoln, Nebraska to help an engaged couple get married and combine a family of three and a family of four into a family of seven (Described by Ty as "The Modern Day Brady Bunch").

Ty's Secret Room: Kenny and Teresa's master bedroom.

Now, the design team heads to Chicago to make a new home for a Latino family of eight whose parents help out teens who are involved with drugs and gangs and turns their lives around, after the father did the same thing as a teen.

Ty's Secret Room: 3rd floor music room for the entire family.
Special guests: John Cena, Batista and Ashley Massaro.

Ty and the design team visit Raleigh, North Carolina to help a family, William and Linda Faye Riggins, and their three children, whose mother, a schoolteacher, is suffering from arthritis, and whose dad is blind.

Ty's Secret Room: William and Linda's master bedroom.
Design Team: Tracy, Paul, John, Ed and Ty

Ty and the design team go to Whitehall, Ohio to help the family of Jason Thomas, a man who risked his life to save two officers' lives in the September 11, 2001 attacks. After the attacks, Jason, his wife, their four children, his wife's aunt, and her daughter, left New York and moved to Ohio to put what happened on that day behind them. This 2-hour event aired a week after the Super Bowl.^{[n 6][n 1]}

Ty's Secret Room: Jason and Kristi's master bedroom.
Design Team: John, Paul, Ed, Tanya and Ty

Ty and the crew head to Austin, Texas to help a family with six kids, five of whom have autism.

Ty's Secret Room: Meaghan's penguin-themed room is the secret project. Meaghan is the only child in the family who does not have autism. There is also a trampoline room not shown on the broadcast.
Design Team: Eduardo, Paige, Paul, Tanya and Ty

Ty and the design team visit Tampa Bay, Florida to help the Tate family after a plane crashed into their Davis Islands home causing a fire that gutted the home, but left the main structure intact.

Ty's Secret Room: Ryan's camouflage-themed room (he was a Marine in Iraq) with a small kitchen, bathroom, and living room included; in addition, Ty gave Ryan a new Ford Super Duty truck. During the interview, Ryan said that he thought either his brother, sister or parents would have their room done as a Secret Project, but was surprised when he learned his room was Ty's project.

Ty and the design team travel down to Waleska, Georgia to help a single mother of two daughters. Two years ago, a fire burned down the home. The only boy in the family, Ransom (a budding architect) was killed in an auto accident three months later.

Ty's Secret Room: Miss Faith's master bedroom, containing a shrine in memory of Ransom.
Design Team: Paul, Michael, Tanya, John and Ty

The team heads to Myrtle Beach, South Carolina where they build a new home for a grandmother and her four grandchildren, who live in a ramshackle trailer held together by duct tape.

Ty's Secret Room: Renee's master bedroom
Design Team: Preston, Paul, Tanya, Paige and Ty

An altruistic nurse and single mother of three has her dilapidated Mississippi home rebuilt by Ty and his team. In addition to receiving a 2007 Ford Edge, the family will also receive a makeover on their garage, having been the winners of a contest where Ford gave away fifty Edges (one for each state).

Ty's Secret Room: Sabrena's master bedroom.
Design Team: Michael, Paige, Eduardo, John and Ty

The team heads to Lawton, Oklahoma to help Gene Westbrook, a US soldier who was injured in Iraq and became disabled when a bomb went off near his tent in 2004. Just two years later, the family (minus Elizabeth) were injured in a car accident. Katie needed extreme surgery to remove one of her kidneys, and worse, Gene suffered broken legs, a stroke, and a bloody mouth, but Peggy survived with minor injuries. This left mom Peggy and fifteen-year-old Elizabeth as the only family members who did not end up needing a wheelchair or surgery. It's revealed that because nine-year-old James is an avid video game fan, he'll be inserted into Ratchet & Clank Future: Tools of Destruction, a new video game being developed by Insomniac Games for PlayStation 3.

This episode marks them return of Ed and begins with a recap of the serious incident he had during the Thomas family episode.

Ty's Secret Room: James video game-themed room (one of the only times we don't see Ty telling the recipient(s) about his secret project prior to reveal)

The team heads further up north to Murfreesboro, Arkansas, where they work on the home of Dennis and Kim Collins and their son Mitchell (who was diagnosed with a brain tumor when he was 3). Also in the family are five cousins of Mitchell whose parents were killed in an auto accident.

Ty's Secret Room: Mitchell's bedroom, made of pop tabs you'd find on soda cans.

The team heads north to south-eastern Pennsylvania - this time to help the family of MaryNoel Kilgallon, a divorced mother of four who can't help the financial issues with her house. During the episode she performed in a live stage production of Beauty and the Beast. This made her family and herself very happy.

Ty's Secret Room: MaryNoel's master bedroom
Design Team: Preston, Paul, Tracy, Eduardo and Ty

The team travels southwest to Kansas City, Missouri to help the family of Jesús and Michelle Jacobo, who took in five more kids to add to their four after Michelle's sister verbally and physically abused them. Also in the family is grandpa Ray (on Michelle's side), who lives with them. Not mentioned in the episode (but in an article) is that Michelle is a diabetic.

Ty's Secret Room: Jesús and Michelle's master bedroom. In addition, he also made a room for Merriam, the Jacobo's newborn daughter.

The team travels to upstate New York to help Debbie Oatman-Gaitan, a single mother who adopted three children, two of whom are HIV positive. They were living in an unsuitable environment, where the foundation of their old home was sinking into the ground. A new recreation center was built, replacing a demolished unused laundry building, at Camp Heartland for children with HIV.