Ty and the gang travel to Kalihi, Hawaii to renovate the home of the Akana family. In addition to renovating the Akana family home, Ty and his team also renovate the KOKA Family Learning Center, which the family has run for more than eleven years. The Akana family consists of Theresa (a.k.a., "Momi"), her husband Ben, her three children, and their daughter. The children are fourteen-year-old Keahi, twelve-year-old Kuʻulei, eight-year-old Maka, and baby Poli. Momi Akana was a single mother on welfare when she started the Keiki O Ka ʻĀina (KOKA) Family Learning Center. Keiki O Ka ʻĀina means "Child of the land" in the Hawaiian language; the center helps struggling moms and their kids. Keahi Akana is now the lead singer and guitarist of the band "Further than our Sky."^{[n 1]}

Ty's Secret Project: Ben & Momi's master bedroom

Ty and the crew head up to Corvallis, Oregon to take on the home of Rob and Rachel Byers and their three children, 13-year-old Joe, 14-year-old Chris, and 8-year-old Jenessa, nicknamed "Boey", who had been battling cancer for the past two years. On December 28, 2007, this special girl lost her battle only 12 weeks after the episode aired.^{[n 2]}

Ty's Secret Project: Boey's fashion boutique themed room

In this episode Ty and the crew head to Bridgeport, Connecticut to rebuild the home of the Brown Family, which was damaged by flooding, looting and fire.

Ty's Secret Project: Gloria's Room
Design Team: Paige, Eduardo, John, Michael and Ty

Ty and the crew head to Billings, Montana to a take on the home of Lon and Julie Carter and their three daughters Jade, Sapphire and Chalce-Donae who live in a refurbished chicken coop. Julie and Jade both have a very rare and very serious brain malformation called Chiari malformation. According to an online article, Sapphire and Chalce-Donae have a similar disease as well. These three sisters won't let pain keep them down though. All three are aspiring musicians. As an interesting side note, all three sisters have tattoos honoring the three-brother band Hanson and list them as their greatest musical inspiration.

Ty's Secret Project: Lon and Julie's master bedroom

The team rebuilds the home of a Navajo family that has been living without running water and heat for the past five years.

Ty's Secret Room: Georgia's Master Bedroom

The team makes their first stop in Wyoming to help a family who takes care of their animals, along with their two kids, both of whom have heart defects because of the air in their house being contaminated with radon. Ty's Secret Project: Dan and Dawn's master bedroom.
Design Team: Paige, Eduardo, John, Rib and Ty Special Guests: David Beckham and Wynonna Judd

Ty and the crew head to New Jersey to help a cancer-stricken father, 54-year-old Victor, who has been raising his five teenage sons ever since their mother abandoned them twelve years prior. They live in a run-down rental town-home in Camden with holes in the walls, bad plumbing, few furnishings, and no beds (the oldest slept on the living room couch). The father was unable to work due to two previous heart-attacks, and had started a local organization called "Single Fathers of Camden". Lack of money has left him wondering where his sons' next meal would come from, and left him forced to hold meetings for SFOC in his backyard ^{[n 3]}

Ty's Secret Project: A room stocked with video games, paintings, the works. Ty dubbed it "The Lion's Den".

For the show's 100th episode, Ty and the design team head to Minnetonka, Minnesota to help Erik and Vicki Swenson and their seven children; Taylor, 13, Samantha, 10, Trevor, 10, Tyler, 9, Tara, 7, Stella, 2, and Olivia, 2. Four of the children (Taylor, Trevor, Tyler, and Tara) are actually Vicki's nieces and nephews. Vicki's sister, Teri Lee, and her boyfriend, Tim, were murdered by Teri's ex-boyfriend. These four children became orphans (their father was killed in a car wreck five years earlier), and Erik and Vicki welcomed them into their home. Taylor was actually in the car when her father died and was with her mom when she was murdered. With seven children and another one on the way, the Swenson-Lee Family quickly outgrew their three bedroom home. Despite all these challenges Taylor and Vicki are advocates against domestic violence. Eight families from previous seasons also appeared to help out.^{[n 1][n 4]}

Ty's Secret Project: Family Room/Play Room
Design Team: Paul, Michael, Tracy, Paige and Ty

The families that help out in the episode are:

• The Ripatti-Pearce family (Redondo Beach, California) from Episode 4.11
• The Kubena family (East Bernard, Texas) from Episode 3.17
• The Ginyard family (Capitol Heights, Maryland) from Episode 3.6
• The Piestewa family (Tuba City, Arizona) from Episode 2.24
• The Johnson family (Kansas City, Missouri) from Episode 2.22
• The Burns family (Garden Grove, California) from Episode 2.9
• The Wofford family (Encinitas, California) from Episode 2.1
• The Cadigan-Scott family (Livermore, California) from Episode 1.12

Special Guest: Elmo played by Kevin Clash from Sesame Street in association of Sesame Workshop. Elmo Segment Director: Victor DiNapoli
Design Team Footages: Eduardo, Ed, Daniel, Constance and Preston

A family whose four kids have a rare disease known as eosinophilic enteropathy, which causes their white blood cells to think that the food they eat is a parasite and attack it. They have numerous medical complications as a result, and their dilapidated home is making matters even worse. They are much loved by their parents and their dad is a hero because he has decided to go back to school to find a cure for his children.

Ty's secret room: The kitchen, plus a sterile kitchen for preparing formula.

A family whose youngest son, 2-year-old Louis, has numerous skeletal abnormalities and uses a wheelchair. He has amazed everyone with his ability to paint. His split-level, dilapidated house is really dangerous as it is wheelchair inaccessible and dangerous for Louis's immune system.

Ty's secret room- Louis's therapeutic room.

After discovering that the second most common cause of childhood deaths in Washington state was drowning, Connie Chapin, a single mother of 3 daughters and a son set up a swim school called Angelfish in her family pool. Unfortunately the local authority threatened to close it down because her 100-year-old house was structurally unsafe. This was the first time that the build took more than 7 days to complete, as consistent rain forced the build to run long, and the family was brought home on the morning of Day 8.

Ty's secret Project- Molly's interior design themed bedroom.

Ty and the team head to Milbridge, Maine to help Brittany Ray, a teacher at Narraguagus High School who received the Maine 2007 Teacher of the Year award, and her family: her husband, a fellow school teacher, daughter Bayley, and sons Thomas and Jojo. Thomas has autism and Jojo is showing the signs of autism as well. In addition, the family has a genetic disposition towards high cholesterol. The house has been in Brittany's family for over 100 years, but is unsafe and must be demolished. However, it is purportedly haunted by the spirits of Brittany's ancestors. Thus, Ty and Paul must consult a medium to determine if the spirits are willing to allow demolition; the spirits choose portions of the old house to incorporate into the design of a new one.

Ty's secret project: Master Bedroom (the walls feature pictures of a crow, symbolizing that a departed relative watches over the family, a tribute to her haunting the old house)

Design Team: Paul, Eduardo, John, Didiayer and Ty

EM:HE heads over to Colorado Springs, Colorado to help the Woodhouse family, whose ten-year-old daughter, Kayla, has a rare disease called Hereditary Sensory Autonomic Neuropathy (specifically, Type 4, also known as Congenital insensitivity to pain with anhidrosis; only 25 people in the world have been diagnosed with this disease). As a result, she can't feel pain and if her body temperature starts increasing, it can't come down without medical intervention, and any extreme high temperatures could kill her. She has to be indoors most of the time with the thermostat set at 62 degrees at all times. Ty and the crew send the family to a ranch in a part of Colorado where the average temperature is 59 degrees year round.

Ty's Secret Project: Kayla's water themed room (she loves swimming; the cool temperature of the water helps regulate her body temperature)

Design Team: Rib, Eduardo, Tanya, Ed and Ty

(Recorded October 14–22, 2007) In this episode, which many consider the largest build yet, the Extreme Team head to Port Deposit, Maryland to build a house, indoor riding arena and fully renovate a horse stable for people with disabilities after the father, Carl, died of liver cancer. ^{[n 1]} and they can go on a Vacation to Italy.

Ty's Secret Project: Renee's master bedroom

(Recorded October 18–25, 2007) Ty and the design team head to Manchester, NH to help Reynald and Casey Voisine and their four children who lost their home to the 2006 New England flood. As a bonus they also delivered a house to the Herod family built by an organization called "There's No Place Like Home", who also lost their home to the same flood, as well as a $15,000 check to the same organization. For more Info on "There's No Place Like Home" visit www.placelikehome.org ^{[n 1]}

Ty's Secret Project: The garage, known as "Garage Mahal". This is the second garage to have been a Secret Project; the first was back in 2004, on the McCrory family episode.

Single father Daniel lost his leg while serving in Iraq and his tiny, dilapidated home is not accessible for him.^{[n 1]}

Ty's Secret project: Daniel's office.

The team heads to Louisville to help the family of Patrick Henry Hughes, a blind man with a talent for music. He is in a wheelchair and the home was not accessible for him. Not only does the design team renovate the home, they also renovate the University of Louisville football field (Patrick Henry was in the marching band, courtesy of his father pushing him around) to make it more accessible for him.^{[n 1]}

Ty's Secret Project: A wheelchair accessible mini-apartment for Patrick Henry.

Design Team: Paul, Michael, Didiayer, Eduardo and Ty (Ed traveled with the family in his hometown of London, England while they're vacationing, as a tour guide).

The team goes to Virginia to help military father, Michael, and his wife and two boys. His younger son, Joseph, has autism. Michael loves history, so he started to build his dream home on a landscape which served as a setting for Civil War battles. He was called over to Iraq and could never finish it, so the Extreme Makeover: Home Edition design team lends a hand.

Ty's Secret Project: Michael and Jean's master bedroom
Design Team: Ty, Paul, Michael, Rib and Phyllis

Richard and Angie Turner dedicate themselves to their community by Richard being a football coach to a team of troubled kids, while Angie is trying hard to get her Master's Degree, so she can be a teacher. Their house is very small and cramped for seven people. It's up to Ty and the gang to help this large family get a bigger house.

Ty's Secret Project: Richard and Angie's master bedroom

Steve is a preacher who spreads the word by riding his motorcycle. Steve and Mary are loved by every teen in their community, when they opened a rec room for troubled teens and even cook them dinner. They love doing what they do, but both their trailer and rec room needs repairing. Also, Steve's grandson, Joshua, has respiratory problems and uses a tracheotomy.

Ty's Secret Project: A new rec room for the teens, including new pool tables and air hockey tables

When the youngest son, Peter was diagnosed with Down syndrome, this inspired the family to start opening up to their community for people with special needs and they opened a special camp called "Camp Smile." With all of this love from their community, Ty and the crew give back to the Gaudet Family by giving them a better house with better conditions after Hurricane Katrina struck and made the house conditions even worse.

Ty's Secret Project: Peter's therapeutic room (also not revealed to the recipient prior to reveal, similar to James' room in the Westbrook episode)

Ju-Juanna Latif dropped out of high school, becoming a single teen mother. She was forced to move into a homeless shelter with her son. Things got better when she managed to go to college and buy a home. She had three more kids (including James, who used a wheelchair) and welcomed "Miss Rose" Morgan into their family, who lives next door to them (on the other side of a duplex). The house was really cramped and Ty was amazed to see exactly how wheelchair-inaccessible the house was (Miss Rose's house was covered in plastic sheeting to keep out the cold).

Ty's Secret Project: Ju-Juanna's Room

A family who moved to Albuquerque so their father (a pastor named Gerald) could help out a troubled neighborhood filled with crime. He helped reform numerous lives and is much loved. Unfortunately, his fixer-upper duplex that he and his family are living in is open to everyone, and the family no longer has any privacy. The design team demolishes an entire block and build the family a new home, a dorm room for the people who need to sleep, and a rec room for people to come in to avoid living on the streets.^{[n 1]}

Ty's secret room- Gerald and Liesa's master bedroom.

A former race car driver Ken and his wife Doreen along with their 5 children (3 adopted) have a house that is contaminated with lead poisoning. Ty and the design team not only tear down the house, they dig down deep enough to get all of the lead out of the property.

Ty's Secret Project: Ken and Doreen's Master Bedroom.

On the day his daughter is born, Paul Giunta gets into a serious accident on his way home from the hospital. Doctors didn't think he'd live through the night. When he did, they said he'd never speak or walk ever again. He defied the odds and talks and walks a little with the help of a walker. He has never lived in the same house as his daughter due to the house not being wheelchair accessible.

Ty's Secret Project: Renee's Hair Salon room Design Team: Michael, Paige, Tanya, Paul and Ty

On the final episode of the 50-state tour, Ty and the crew head down to New Orleans to help the entire city, while still working on the home of fireman Brad Usea and his family, including wife Laura, and two daughters, Abby and Audrey. Also being made over is a nearby church, Noah's Ark Baptist.^{[n 1]}

Ty's Secret Project: a bedroom for Brad's brothers, Chris and Chad
Design Team: Michael, Tracy, Eduardo, Paige, Ed, Paul and Ty