Given Imaging

Given Imaging Ltd.
Company type	Private
Traded as	Nasdaq: GIVN; TASE: GIVN;
Industry	Medical technology
Founded	1998; 26 years ago
Headquarters	Yokneam Illit, Israel
Key people	Homi Shamir (CEO)
Products	Capsule endoscopy
Revenue	US$ 177.95 million (2011)
Operating income	US$ 12.98 million (2011)
Net income	US$ 11.97 million (2011)
Owner	Medtronic
Number of employees	800
Website	givenimaging.com

Endoscopic capsule end-on, showing six LEDs and camera lens.

Given Imaging Ltd. (Hebrew: גיוון אימג'ינג) is an Israeli medical technology company that manufactures and markets diagnostic products for the visualization and detection of disorders of the gastrointestinal tract. Until March 2014, it was dual-listed on both the NASDAQ and the Tel Aviv Stock Exchange, where it was a component of the TA-100 Index and the TA BlueTech Index. In March 2014 it was acquired by Covidien and became a private company. In 2015 Covidien was purchased by Medtronic.

Given Imaging pioneered the capsule endoscopy technology and has also developed capsule-based pH monitoring.^[1] Through Sierra Scientific Instruments, a subsidiary, Given Imaging also provides an array of diagnostic modalities including high-resolution manometry and ambulatory reflux monitoring. Given Imaging's technology is currently marketed in over 60 countries.

History

Given Imaging was founded in 1998 by Gavriel Meron and Rafael Development Corporation (RDC) Ltd. based on the purchase of an early patent from Rafael Advanced Defense Systems Ltd. Initial funding for the company was provided by Elron Electronic Industries, Israel's leading technology holding company, in cooperation with Rafael. Today, Elron still holds 28% Given Imaging's shares.^[2] The idea for the solution was developed by Dr. Iddan, while working in the missile division of Rafael, where he envisioned that missile technology could be miniaturized to create a medical product.^[3]

The company's first capsule endoscopy products was named M2A capsule and received it CE marking in May 2001 and in August 2001 was cleared by the US Food and Drug Administration (FDA) for visualization of abnormalities of the small intestine^[4] The capsule uses a radio developed for Given by Zarlink Semiconductor's medical team in San Diego and Jarfalla, Sweden.

In October 2001, Given Imaging had an Initial public offering on NASDAQ under ticker GIVN.)^[5] In September 2004, M2A capsule re-branded PillCam SB(R).

In March 2004, Given Imaging became a member of the Tel Aviv Stock Exchange^[6]

In November 2004, US FDA clears PillCam(R) ESO for the esophagus

In May 2006, US FDA clears Agile Patency System^[7]

In October 2006, PillCam COLON was cleared for marketing in the European Union (CE Mark)^[8]

In December 2008, Given Imaging acquired Bravo pH Monitoring System(R)

In May 2009, 1 millionth PillCam capsule was sold^[9]

In September 2009, PillCam COLON 2 receives CE Mark^[10]

In July 2012, Given Imaging's capsule endoscopy featured in a live broadcast on the BBC, when the reporter Michael Mosley spent the day as an exhibit at the Science Museum in London, after swallowing a PillCam which transmitted live pictures to a public screen.^[11]

In February 2014, 100% of Given Imaging's shares were purchased by Covidien, making it a Private Company fully owned by Covidien. As a result, its shares are no longer traded neither in NASDAQ nor in TASE^[12]

In 2015 Covidien was purchased by Medtronic

Products

PillCam SB

PillCam SB is a tool for visualization of the entire small bowel and detection of small bowel abnormalities. No sedation is needed, however bowel prep is needed. A liquid bowel prep is consumed before the procedure emptying the bowel completely, this allows clear photos to be taken.^[13]

PillCam ESO

PillCam ESO provides a method for visualization of the esophagus.^[14]

PillCam COLON 2

PillCam COLON 2 is complementary to traditional colonoscopy and is used for patients who have received incomplete colonoscopy, are contraindicated for colonoscopy or are unwilling to undergo traditional colonoscopy.^{[citation needed]}

PillCam CROHN'S

The PillCam CROHN’S system offers direct visualization of the entire small bowel and colonic mucosa with a noninvasive procedure.

PillCam Express

In May 2010, Given Imaging released a new manually guided GI scope based on PillCam swallowable devices. In cases where patient anatomy does not allow for natural passage of large tablets the size of traditional PillCams, the PillCam Express can be delivered through the stomach and into the small intestine with help of an endoscope and a proprietary balloon deployment mechanism.^[15]

Bravo pH Monitoring System

The Bravo pH Monitoring System is a catheter-free ambulatory pH test.^[16] Ambulatory pH testing is considered the gold standard for pH measurement and monitoring of gastric reflux, helping clinicians manage gastroesophageal reflux disease (GERD). Featuring data collection for up to 96 hours, Bravo allows patients to maintain their regular diets and activities, accurately reflecting normal physiologic conditions.^{[citation needed]}

Sierra Scientific Instruments

In April 2010, Given Imaging acquired Sierra Scientific Instruments.^[17]

Headquarters and plants

The company's corporate headquarters, research and development laboratories, and manufacturing facilities are located in Yokneam, Israel.^[18]^[19] It maintains offices in Duluth, Georgia and Heerlen, Netherlands. Additional sales and marketing offices are located in France, Japan, Australia, and Singapore. The company also has a plant in Ireland.^{[citation needed]}

Given Imaging's wholly owned subsidiary, Sierra Scientific Instruments, is located in Los Angeles, California, with manufacturing operations in Vietnam.^{[citation needed]}

References

^ "Invest in Israel: Given Imaging". Archived from the original on 2011-07-21. Retrieved 2010-10-14.
^ Elron Announces That Given Imaging, Held Directly and Indirectly 15% by Elron, Announced Initial Public Offering. Business Wire, October 4, 2001^{[dead link‍]}
^ "RDC – Rafael Development Corporation Ltd - Given Imaging Copnay History". Archived from the original on 2014-08-02. Retrieved 2019-12-29.
^ Athena: Clinical Policy Bulletin: Capsule Endoscopy
^ Given Imaging: First IPO since August IPO Report - MarketWatch - 4 Oct 2001
^ Given Imaging Registration Document March 22, 2004
^ "Given Imaging's Agile(TM) Patency System Receives US Marketing Clearance, Medical News Today, 17 May 2006". Archived from the original on 24 September 2010. Retrieved 16 October 2010.
^ "Pillcam(R) COLON May Be A Cost-Effective Strategy For Preventing Colo-Rectal Cancer, Study, Medical News Today 11 Apr 2008". Archived from the original on 4 January 2009. Retrieved 16 October 2010.
^ Given Imaging Announces One Millionth PillCam Video Capsule, Marketwire May 20, 2009
^ Given Imaging'c PillCam COLON 2 video capsule and system receives the CE mark for sale in Europe, The Medical News, 14. September
^ The second brain in our stomachs, 12 July 2012, Michael Mosley, BBC
^ Announcement Regarding Completion of Merging with Covidien
^ "Given Imaging to Launch Advanced PillCam(TM) SB Video Capsule for the small bowel". Archived from the original on 2009-02-20. Retrieved 2010-10-14.
^ The accuracy of PillCam ESO capsule endoscopy versus conventional upper endoscopy for the diagnosis of esophageal varices: a prospective three-center pilot study. Endoscopy. 2006;38(1):1-5. 20. Eliakim R, Fireman Z, Gralnek IM, Yassin K, Waterman M, Kopelman Y, Lachter J, Koslowsky B, Adler SN. Evaluation of the PillCam Colon capsule in the detection of colonic pathology: results of the first multicenter, prospective, comparative study. Endoscopy. 2006 Oct;38(10):963-70.
^ MedGadget: PillCam Express^{[permanent dead link‍]}
^ "Endoscopy Unit - Bravo PH Monitoring System - Wooster Community Hospital". Archived from the original on 2010-10-25. Retrieved 2010-10-16.
^ Given Imaging Acquires Sierra Scientific Instruments | MDDI Magazine
^ Updating website
^ Present website (July 2023)

[1] "Invest in Israel: Given Imaging". Archived from the original on 2011-07-21. Retrieved 2010-10-14.

[2] Elron Announces That Given Imaging, Held Directly and Indirectly 15% by Elron, Announced Initial Public Offering. Business Wire, October 4, 2001^{[dead link‍]}

[3] "RDC – Rafael Development Corporation Ltd - Given Imaging Copnay History". Archived from the original on 2014-08-02. Retrieved 2019-12-29.

[4] Athena: Clinical Policy Bulletin: Capsule Endoscopy

[5] Given Imaging: First IPO since August IPO Report - MarketWatch - 4 Oct 2001

[6] Given Imaging Registration Document March 22, 2004

[7] "Given Imaging's Agile(TM) Patency System Receives US Marketing Clearance, Medical News Today, 17 May 2006". Archived from the original on 24 September 2010. Retrieved 16 October 2010.

[8] "Pillcam(R) COLON May Be A Cost-Effective Strategy For Preventing Colo-Rectal Cancer, Study, Medical News Today 11 Apr 2008". Archived from the original on 4 January 2009. Retrieved 16 October 2010.

[9] Given Imaging Announces One Millionth PillCam Video Capsule, Marketwire May 20, 2009

[10] Given Imaging'c PillCam COLON 2 video capsule and system receives the CE mark for sale in Europe, The Medical News, 14. September

[11] The second brain in our stomachs, 12 July 2012, Michael Mosley, BBC

[12] Announcement Regarding Completion of Merging with Covidien

[13] "Given Imaging to Launch Advanced PillCam(TM) SB Video Capsule for the small bowel". Archived from the original on 2009-02-20. Retrieved 2010-10-14.

[14] The accuracy of PillCam ESO capsule endoscopy versus conventional upper endoscopy for the diagnosis of esophageal varices: a prospective three-center pilot study. Endoscopy. 2006;38(1):1-5. 20. Eliakim R, Fireman Z, Gralnek IM, Yassin K, Waterman M, Kopelman Y, Lachter J, Koslowsky B, Adler SN. Evaluation of the PillCam Colon capsule in the detection of colonic pathology: results of the first multicenter, prospective, comparative study. Endoscopy. 2006 Oct;38(10):963-70.

[15] MedGadget: PillCam Express^{[permanent dead link‍]}

[16] "Endoscopy Unit - Bravo PH Monitoring System - Wooster Community Hospital". Archived from the original on 2010-10-25. Retrieved 2010-10-16.

[17] Given Imaging Acquires Sierra Scientific Instruments | MDDI Magazine

[18] Updating website

[19] Present website (July 2023)

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Given Imaging

History

Products

PillCam SB

PillCam ESO

PillCam COLON 2

PillCam CROHN'S

PillCam Express

Bravo pH Monitoring System

Sierra Scientific Instruments

Headquarters and plants

See also

References

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