In the 1980s the club was a center for Chicago's Punk and New Wave scenes.[6] In 1988, on the advice of one of the bartenders employed by Neo's management, the bar was renovated to look like lower Wacker.[12][13]
In 2009, Neo celebrated its 30th anniversary and was Chicago's oldest nightclub.[14]
In 2015, the nightclub lost its lease and had to move to a new location.[15][16][17][13] Since 2017, the club is currently located inside the Debonair Social Club at 1575 N Milwaukee Avenue at Chicago.