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In organic chemistry, polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone (>C=O...

Polyketide synthases (PKSs) are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites...

isolated from cultures of S. rimosus. Streptomyces rimosus's oxytetracycline polyketide synthase acyl carrier protein differs from most ACPs by having a C-terminus...

also known as the polyketide pathway, is a fundamental biosynthetic route in organisms for the production of fatty acids and polyketides. This pathway operates...

Aromatic polyketides are assembled by a type II (iterative) polyketide synthase in bacteria. Iterative type II polyketide syntheses produce polyketide chains...

ω−3), Marine bacteria and the microalgae Schizochytrium use an anerobic polyketide synthase (PKS) pathway to synthesize DHA. The PKS pathway includes six...

synthases and to Type I polyketide synthesis. But, in contrast to fatty acid synthesis, the keto groups of the growing polyketide chain are not modified...

class of aromatic polyketide antibiotics, also known as bacterial aromatic polyketides, produced by Streptomyces via type II polyketide synthases (PKSs)...

instructions of microbes for making natural product polyketides. Rearranging the modular units in natural polyketide synthases, combining modules from different...

produced by Escherichia coli and other Enterobacteriaceae. Colibactin is a polyketide peptide that can form inter-strand crosslinks in DNA. Colibactin forms...

either from type ll polyketide or shikimate pathways. This claim was not disputed until a key intermediate exclusive to the polyketide pathway was isolated...

Borrelidin is an 18-membered polyketide macrolide derived from several Streptomyces species. First discovered in 1949 from Streptomyces rochei, Borrelidin...

Muironolide A is a tetrachloro polyketide discovered in 200 that has two unusual structural details: a hexahydro-1H-isoindolone-triketide ring and a trichlorocarbinol...

a family of protein cofactors that participate in fatty acid (acyl), polyketide (acyl and aryl), and nonribosomal peptide (peptidyl) biosynthesis. The...

polyketide are in RapC. Then, the linear polyketide is modified by the NRPS, RapP, which attaches L-pipecolate to the terminal end of the polyketide,...

Fostriecin is a type I polyketide synthase (PKS) derived natural product, originally isolated from the soil bacterium Streptomyces pulveraceus. It belongs...

Chlorotonil A is a polyketide natural product produced by the myxobacterium Sorangium cellulosum So ce1525. It displays antimalarial activity in an animal...

17C polyketide monic acid and the 9C fatty acid 9-hydroxy-nonanoic acid. The possibility that the entire molecule is assembled as a single polyketide with...

the family of transferases, it has been identified as part of a Type 1 polyketide synthase module. DEBS is found in Saccharopolyspora erythraea and other...

into four major classes: terpenes, phenylpropanoids (i.e. phenolics), polyketides, and alkaloids. Terpenes constitute a large class of natural products...

assembly of the a linear polyketide by use of seven modules and incorporation of six methylmalonyl CoAs and one malonyl CoA by polyketide synthases (type I PKSs)...

biosynthesis of nonribosomal peptides shares characteristics with the polyketide and fatty acid biosynthesis. Due to these structural and mechanistic similarities...

Xanthohumol is a prenylated chalconoid, biosynthesized by a type III polyketide synthase (PKS) and subsequent modifying enzymes. Xanthohumol is a prenylated...

synthase (OLES) follows the module structure of a type I synthase. The polyketide chain is bound through thioester linkages to the S-H groups of the ACP...

protein phosphatases, and has a variety of negative effects on cells. A polyketide, polyether derivative of a C38 fatty acid, okadaic acid and other members...

Swinholides are dimeric 42 carbon-ring polyketides that exhibit a 2-fold axis of symmetry. Found mostly in the marine sponge Theonella, swinholides encompass...

with a strain of the Burkholderia gladioli bacterium, which produces a polyketide that protects the beetle's eggs against fungal and also bacterial infections...

focused on two realms: the first is to build a molecular understanding of polyketide synthases, and the second is focused on the biochemistry of celiac disease...

produces viridicatumtoxin and griseofulvin, two structurally interesting polyketides. List of Penicillium species MycoBank "Straininfo of Penicillium aethiopicum"...

genomic sequence of nystatin reveals the presence of the polyketide loading module (nysA), six polyketide syntheses modules (nysB, nysC, nysI, nysJ, and nysK)...

of avermectin production: 1) production of the avermectin aglycon by polyketide synthases, 2) modification of the aglycon, 3) synthesis of modified sugars...

Integrasone is a polyketide natural product, isolated from an unknown fungus, that has been shown to inhibit the HIV-1 integrase enzyme. Integrasone occurs...

Tylactone synthase or TYLS is a Type 1 polyketide synthase. TYLS is found in strains of Streptomyces fradiae and responsible for the synthesis of the macrolide...

previously presented Priming beta-ketosynthase in chemistry, a domain of polyketide synthases with a thiol group on a cysteine side-chain The process by which...

generate enolate is a common strategy in biosynthetic pathways such as polyketide synthesis, where malonic acid half thioester can be converted to the corresponding...

constituent of the Cannabis plant. It is also a meroterpenoid (i.e. a polyketide and a terpenoid), a member of resorcinols and a phytocannabinoid. It derives...

anticancer effects. It was suggested that lac insects employ polyketide pathway catalysed by polyketide synthase to produce laccaic acid D, a common precursor...

iterative polyketide synthase (PKS) pathway. This type I PKS loads Acetyl-CoA and then repeatedly adds a total of seven Malonyl-CoAs. The growing polyketide is...

and type II polyketide synthesis, or as domains in large multidomain enzymes, such as type I fatty acid synthases (FASs) and polyketide synthases (PKSs)...

\rightleftharpoons } 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 This polyketide synthase catalyse the first step in the cannabinoids biosynthetic pathway...

roquefortine C, shikimic acid, griseofulvin, and 6-Methylsalicylic acid (via a polyketide synthase). Penicillium griseofulvum occurs on cereals and nuts. Fletcher...

taken from the bacterium pseudomonas protegens (Pf-5), is a type III polyketide synthase. The enzyme cyclizes the activated form of 3,5-dioxoheptanedioate...

Apratoxin family of cytotoxins. The mixed peptide-polyketide natural product comes from a polyketide synthase/non-ribosomal peptide synthase pathway (PKS/NRPS)...

produce bioactive compounds called mycotoxins, such as alkaloids and polyketides, that are toxic to animals, including humans. The fruiting structures...

glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, and polyketides (derived from condensation of ketoacyl subunits); and sterol lipids and...

Disorazol, a cyclic polyketide synthesized by the bacterium Sorangium cellulosum So ce12, was first detected and isolated in 1994. Its chemical structure...

Sanglifehrin A is a polyketide natural product found to potently inhibit cyclophilins and have immunosuppressive activity. Isolation and characterisation...

Protopic. The biosynthesis of tacrolimus is hybrid synthesis of both type 1 polyketide synthases (PKS 1) and nonribosomal peptide syntheses (NRPS). The research...

Pladienolide B is a polyketide natural product that is made by the bacterium Streptomyces platensis MER-11107, which is a gram-positive bacteria isolated...

in Schizochytrium occurs via a Polyketide synthase (PKS)-based pathway, although the primary structures of the Polyketide synthases do not conform to any...

genes ann4 and ann5 encode two polypeptides that correspond to a type 1 polyketide synthase PKS. The biosynthesis of the C5N ring was recently reconstructed...

bacterium in the genus Kytococcus. It is known for the production of polyketide antibiotics as well as for its role as an opportunistic pathogen. It is...

natural product belonging to a family of 22- to 26-membered macrocyclic polyketides which is featured with a 6,6-spiroacetal (1,7-dioxaspiro[5,5]-undecanyl)...

{\displaystyle \rightleftharpoons } 2 CoA + 4-hydroxycoumarin + CO2 This polyketide synthase can also accept benzoyl-CoA as substrate. Liu B, Raeth T, Beuerle...

tailor the polyketide using malonyl-CoA, methylmalonyl-CoA, and ethylmalonyl-CoA. The final thioesterase domain hydrolyzes the polyketide to form the...

vancomycin and other related compounds. DHPG is enzymatically derived from the polyketide synthase pathway. When synthesized in bacteria, DHPG requires 5 enzymes...

cholesterol. In 1982, some small-scale clinical investigations of lovastatin, a polyketide-derived natural product isolated from Aspergillus terreus, in very high-risk...

synthase categorizes three enzyme isoforms (CURS1, 2, and 3), type III polyketide synthases (PKSs) present in the leaves and rhizome of the turmeric plant...

from sixteen 'C2' acetate and three 'C3' propionate units by polyketide syntheses. Polyketide biosynthesis begins with the decarboxylative condensation of...

chemotherapeutic drugs. In 2009, a study showed that O. unilateralis also produces polyketides. These secondary metabolites have been used in antibiotics such as patulin...

cyclic polyketide derivative originating from the acetate pathway. Geranylgeranyl pyrophosphate is believed to condense with the cyclic polyketide derivative...

Arts degree in Natural Sciences in 1979 followed by PhD on the topic of polyketide biosynthesis for research supervised by James Staunton in 1982. Abell...

f. [51615-30-6]) Y-39677 [312688-85-0] Splitomicin Aldol condensation Polyketide synthase Dieckmann condensation Claisen condensation Smith, Michael B...

brocazine D, brocazine F, bisthiodiketopiperazine, penicibrocazine C and the polyketides brocaenol A, brocaenol B, and brocaenol C. List of Penicillium species...

particularly important in metabolic pathways that generate precursors for polyketide synthesis and other secondary metabolites. Post-translational modification...

matrix. This algae species is capable of producing a variety of bioactive polyketide natural products such as ciguatoxin with characteristic fused-ring cyclic...

Mycolactone is a polyketide-derived macrolide produced and secreted by a group of very closely related pathogenic mycobacteria species including M. ulcerans...

Anthracimycin is a polyketide antibiotic discovered in 2013. Anthracimycin is derived from marine actinobacteria. In preliminary laboratory research, it...

marine-derived fungus Aspergillus glaucus for the production of anti-cancer polyketide". Marine Biotechnology. 14 (6): 665–71. Bibcode:2012MarBt..14..665C. doi:10...

known for being the organism from which the polyketide Callystatin A was identified. Callystatin A is a polyketide natural product from the leptomycin family...

are of practical importance as intermediates in the biosynthesis of polyketides. These natural products are a major source of antibiotics. Diketone Fischbach...

still up for debate. It plays a key role in fatty acid biosynthesis and polyketide biosynthesis, fatty acid elongation, fatty acid oxidation via CPT1, the...

enzYme) is database of enzymes constituting the fatty acid synthesis and polyketide synthesis cycles. Thioester Cantu, David C; Chen Yingfei; Lemons Matthew...

Biology of Nonribosomal Peptide Synthetases". Nonribosomal Peptide and Polyketide Biosynthesis. Methods in Molecular Biology. Vol. 1401. pp. 3–29. doi:10...

isolated from soil. Streptomyces resistomycificus produces the pentacyclic polyketide resistomycin. List of Streptomyces species LPSN bacterio.net UniProt Deutsche...

on the biosynthesis of natural products, particularly terpenoids and polyketides. He was elected as a Fellow of the American Association for the Advancement...

the synthesis of the 14-carbon poly-β-keto chain by a type I iterative polyketide synthase (PKS) via iterative addition of 6 malonyl-CoA to an acyl-CoA...

catalyzed by polyketide synthase. Chain extension of 4-hydroxycinnamoyl-CoA with three molecules of malonyl-CoA gives initially a polyketide (figure), which...

early experiment helped establish the rich condensation chemistry of polyketides. It can be obtained by fusing extract of aloes with potash, followed...

Aureothin is a natural product of a cytotoxic shikimate-polyketide antibiotic with the molecular formula C22H23NO6. Aureothin is produced by the bacterium...

receptor TAS2R50. The biphenylcarboxylic acid moiety is biosynthesized by a polyketide-type pathway, with three units of acetyl-CoA and one unit of 3-hydroxybenzoyl-CoA...

to T-toxin. T-toxin is considered to be related to a family of linear polyketides. This organism's appeal among genetic analysts lends itself to the organism's...

elucidation of biochemical crosstalk between fatty acid synthases and polyketide synthases in Mycobacterium tuberculosis. He holds US and Indian patents...

of p-coumarate. Entering the flavone synthesis pathway, the type III polyketide synthase enzyme chalcone synthase uses consecutive condensations of three...

coumarin Aureusidin, an aurone Catenarin, a naphthoquinone Citreorosein, a polyketide Fisetin, a flavonol Kaempferol, a flavonol Isoscutellarein, a tetrahydroxyflavone...

Euglenoidea Polyketide Karlotoxin Karlodinium veneficum Dinophyceae Polyketide / Polyether Karmitoxin Karlodinium armiger Dinophyceae Polyketide / Polyether...

backbone of A-type prymnesins like prymnesin-1 is reportedly made by giant polyketide synthase enzymes dubbed the "PKZILLAs" of which PKZILLA-1 and PKZILLA-2...

James S. (2005-04-01). "Crotylsilane Reagents in the Synthesis of Complex Polyketide Natural Products: Total Synthesis of (+)-Discodermolide". Journal of the...

ansa chain was derived from acetate and propionate, in common with other polyketide antibiotics. The naphthalenic chromophore was shown to derive from a propionate...

large cigar shaped necrotic lesions that develop on the leaves due to the polyketide metabolite monocerin. Races of S. turcica are named for the maize R genes...

Avermectin biosynthesis is classified into three stages: the formation of the polyketide-derived initial aglycone, modification of the initial aglycone to produce...

(CHS) is an enzyme ubiquitous to higher plants and belongs to a family of polyketide synthase enzymes (PKS) known as type III PKS. Type III PKSs are associated...

In enzymology, a 6-methylsalicylic-acid synthase (EC 2.3.1.165) is a polyketide synthase that catalyzes the chemical reaction acetyl-CoA + 3 malonyl-CoA...

in other anthracycline antibiotics, the framework is synthesized by a polyketide synthase and subsequently modified by other enzymes. The structure of...

plants as secondary metabolites. The enzyme chalcone synthase, a type III polyketide synthase, is responsible for the biosynthesis of these compounds. The...

Resveratrol Polyacetylenes, fatty acids and waxes Without nitrogen 1500 Polyketides Without nitrogen 750 Carbohydrates and organic acids Without nitrogen...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Annonacin is a chemical compound with neurotoxic effects in vitro. It is found in some fruits, such as the paw paw, custard apples, soursop, and others...

Actinorhodin is a benzoisochromanequinone dimer polyketide antibiotic produced by Streptomyces coelicolor. The antibiotic effect of the substance was first...

biosynthesized from a hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) pathway. Pyoluteorin was first isolated in the 1950s from...

Ansamycins is a family of bacterial secondary metabolites that show antimicrobial activity against many Gram-positive and some Gram-negative bacteria,...

microbiota. Examples of these molecules include the potent cytotoxic polyketides: pateamine, peloruside, and mycalamide. Rust, Michael; Helfrich, Eric...

McIntyre, C.; Scott, Fiona E.; Sadler, Ian H. (1997-03-17). "Biosynthesis of polyketide-terpenoid (meroterpenoid) metabolites andibenin B and andilesin A in Aspergillus...

rhubarb, and cascara buckthorn, fungi, lichens, and some insects. A type II polyketide synthase is responsible for anthraquinone biosynthesis in the bacterium...

Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination...

usually cladinose and desosamine, may be attached. Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal...

Ericaceae, Lamiaceae, Papaveraceae and Myrtaceae. In lichens, depsides are polyketide-derived secondary metabolites biosynthesized via the polymalonate pathway...

to bio and organic chemists because it produces (+)-discodermolide, a polyketide natural product with immunosuppressive and cancer killing properties....

Malettinins are polyketide-derived antimicrobial compounds produced by fungal ascomycetes in the genus Hypoxylon. Angawi, Rihab F.; Swenson, Dale C.; Gloer...

biosynthesis of prescopranone follows the module structure of a Type I polyketide synthase (PKS) with three elongation modules and a lactonizing thioesterase...

bond is a key step in the biosynthetic pathways by which fatty acids and polyketide are made. The thiolase superfamily enzymes catalyse the carbon–carbon-bond...

where THC accumulates with regular use. THC is a molecule that combines polyketides (derived from acetyl CoA) and terpenoids (derived from isoprenylpyrophosphate)...

mannitol cycle, a new concept in fungal metabolism, and its relation to polyketide formation in Alternaria alternata". LIBRIS. Retrieved April 11, 2010....

"Amphotericin biosynthesis in Streptomyces nodosus: Deductions from analysis of polyketide synthase and late genes". Chemistry & Biology. 8 (7): 713–723. doi:10...

B. Neritina, bryostatin biosynthesis is carried out through a type I polyketide synthase cluster, bry. BryR is the secondary metabolism homolog of HMG-CoA...

PMID 34201951. Chen H, Du L (2016-01-01). "Iterative polyketide biosynthesis by modular polyketide synthases in bacteria". Applied Microbiology and Biotechnology...

fraternity Parkes Catalogue of Radio Sources, an astronomical catalogue Polyketide synthases, a family of enzymes Prosperous Justice Party (Partai Keadilan...

Prymnesin-1 and prymnesin-2 are both are derived from acetate-related (i.e. polyketide) metabolism, based on knowledge about the structure of the prymnesins...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Solorinic acid is an anthraquinone pigment found in the leafy lichen Solorina crocea. It is responsible for the strong orange colour of the medulla and...

Paederus Beetle Archived 2011-06-09 at the Wayback Machine Piel J (2002). "A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

malonyl-CoA, a substrate required for synthesis of flavonoids and related polyketides, for elongation of fatty acids to produce waxes, cuticle, and seed oils...

backbone of B-type prymnesins like prymnesin-B1 is reportedly made by giant polyketide synthase enzymes dubbed the "PKZILLAs". Prymnesin-1 Prymnesin-2 Rasmussen...

Yellow SS. Aldols are also used as intermediates in the synthesis of polyketide natural products and drugs such as Oseltamivir and Epothilone. Aldol reactions...

thousands of specialized metabolites, including waxes, sterols, and polyketides. ATP citrate lyase is the primary enzyme responsible for the synthesis...

hexanoyl-CoA onto a polyketide synthase assembly protein and subsequent condensation with three molecules of malonyl-CoA. This polyketide is cyclized to olivetolic...

41398. This has shown that the polyketide backbone of salinomycin is synthesised on an assembly line of nine polyketide synthase) multienzymes. Furthermore...

dinotoxin synthesis is not widely understood, but the polyketide pathway involving polyketide synthase (PKS) is known to be associated with the production...

revealed the presence of 34 gene clusters involved in the production of polyketide synthase, nonribosomal peptide synthetase, ribosomally synthesized and...

synthesized by the lactic acid bacteria, Enterococcus. This class of polyketide antibiotics are effective against foodborne pathogens including L. monocytogenes...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Carmine (/ˈkɑːrmən, ˈkɑːrmaɪn/) – also called cochineal (when it is extracted from the cochineal insect), cochineal extract, crimson lake, or carmine lake –...

Michael J. (2016). "Enantioselective Alcohol C–H Functionalization for Polyketide Construction: Unlocking Redox-Economy and Site-Selectivity for Ideal Chemical...

Citromycetin is a bio-active polyketide isolated from Australian Penicillium. Capon, RJ; Stewart, M; Ratnayake, R; Lacey, E; Gill, JH (2007). "Citromycetins...

proanthocyanidins, cinnamoylamides, phenylpyrroles, styryl pyrones, polyketides (acetogenins), furanosesquiterpenes, and germacranolidous, heliangolidous...

Biosynthesis of the germicidin A, B, and C is achieved through a type III polyketide synthase called germicidin synthase (Gcs). Surugapyrone A is expected...

Maximiscin is a polyketide-shikimate chemical compound isolated from Tolypocladium that shows tumor growth suppression in an animal model. The discovery...

cluster is well characterized. Jadomycin biosynthesis encompasses type II polyketide synthase (T2Pks) assembly to generate the angucycline component, and a...

desaturase (desA2) while ASpks is found with the open reading frame for Polyketide synthase-12 (pks12) and is an antisense regulator of pks12 mRNA. The sRNA...

keratinophilic fungus Amauroascus niger. The core biosynthetic route is via a polyketide synthase pathway from 10 acetates, 4 methyls of methionines, 1 succinate...

molecular genetics studies have proposed pigment cell clusters expressing polyketide synthase (PKS) and sulfotransferase as a synapomorphy of Xenambulacraria...

Andrimid contains a pseudopeptide backbone and is synthesized through the polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) pathways. Amino...

Uvaricin is a bis(tetrahydrofuranoid) fatty acid lactone that was first isolated in 1982 from the roots of the Annonaceae Uvaria acuminata. Uvaricin was...

by engineered yeast, including phenolics, isoprenoids, alkaloids, and polyketides. About 20% of biopharmaceuticals are produced in S. cerevisiae, including...

Bovenberg RA, Vreeken RJ, Driessen AJ (July 2016). "Identification of a Polyketide Synthase Involved in Sorbicillin Biosynthesis by Penicillium chrysogenum"...

the enzyme pigA performs the oxidation. Ring A is then expanded via the polyketide synthase pathway to incorporate L-serine into ring B (figure 3). Ring...

sp. nov. and Its Secondary Metabolite Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide Compounds". Microorganisms. 8 (3): 370. doi:10...

MKN28, K562, and KB. Like many macrocyclic polyketides, quinolidomicin A1 is biosynthesized by type-I polyketide synthases. Decarboxylative condensations...

produce new combinations with new and complex functions. For example, polyketide synthases are large enzymes that make antibiotics; they contain up to...

other polyene antimycotics, the biosynthesis begins with a series of polyketide synthase modules, followed by additional enzymatic processes for oxidation...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

concentration, while subsequently increasing the concentration of polyketides. A polyketide is a structure commonly found in fungi that is made of acetyl-...

the prostate Acyl carrier protein, a component in both fatty acid and polyketide biosynthesis Anterior chamber paracentesis, a surgical procedure done...

Phaeochromycin A is an anti-inflammatory polyketide isolated from Streptomyces. Graziani, E. I.; Ritacco, F. V.; Bernan, V. S.; Telliez, J. B. (2005)....

a method of processing streamed data Ketoacyl synthase, a domain of polyketide synthases with a thiol group on a cysteine side-chain kilosample (kS)...

secondary metabolite, a polyketide produced from multiple acetyl-CoA and malonyl-CoA units which are combined by a polyketide synthase (PKS) enzyme complex...

Enantioselective carbonyl allylations are frequently applied to the synthesis of polyketide natural products. In 1978, Hoffmann reported the first asymmetric carbonyl...

pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis. As of late 2007, 5 structures have been solved...

to bio and organic chemists because it produces (+)-discodermolide, a polyketide natural product with immunosuppressive and cancer killing properties....

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

macrolide to be isolated. Pikromycin is synthesized through a type I polyketide synthase system in Streptomyces venezuelae, a species of Gram-positive...

Akira; Shizuri, Yoshikazu (June 2008). "Ariakemicins A and B, Novel Polyketide-peptide Antibiotics from a Marine Gliding Bacterium of the Genus Rapidithrix"...

Atrop-abyssomicin C is a polycyclic polyketide-type natural product that is the atropisomer of abyssomicin C. It is a spirotetronate that belongs to the...

4-coumarate-CoA ligase. (E)-4-coumaroyl-CoA is then subjected to the type III polyketide synthase naringenin chalcone synthase, undergoing successive condensation...

Phytotoxins: Mode of Action, Regulation, and Biosynthesis by Peptide and Polyketide Synthetases". Microbiol. Mol. Biol. Rev. 63 (2): 266–292. doi:10.1128/MMBR...

found in diverse natural products including lignans, acetogenins, and polyketide natural products. Diverse methodology has been developed for the synthesis...

in Streptomyces galbus, but these loci are separate from the modular polyketide synthase ge". FEMS Microbiology Letters. 310 (1): 69–75. doi:10.1111/j...

through FAD+ to yield pyrrole ring A. Ring A is then expanded via the polyketide synthase pathway to incorporate L-serine into ring B (figure 3). Ring...

insect host. Another important sequence identified is the gene encoding polyketide and nonribosomal peptide syntheses which produce antibiotics to protect...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

predicted in the next 200 years. Myriapora truncata is the source of 4 polyketide-derived metabolites: Myriaprones 1-4 Wikimedia Commons has media related...

last step. Aldol condensation Stobbe condensation Fatty acid synthesis Polyketide synthase Dieckmann condensation Carey, F. A. (2006). Organic Chemistry...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

suspected to utilize phenylpropanoid pathway and produce putative type III polyketide synthase products based on the research of 6-gingerol biosynthesis by...

when crystallized from water. Orsellinic acid is biosynthesized by a polyketide pathway. Nolan, T. J.; Keane, J.; Davidson, V. E. (1940). "Chemical constituents...

albidoflavus's ACP S-MT is involved in both fatty acid synthesis II and polyketide synthase and is structurally similar to Escherichia coli's analogue. Strains...

biosynthesis of conipyridoin E has been proposed as a hybrid between Type I polyketide synthase (PKS) and an amino acid biogenetic pathway. The decalin moiety...

mutase in the biosynthesis of the unique starter unit of the macrolactam polyketide antibiotic vicenistatin". The Journal of Antibiotics. 58 (7): 468–72....

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

a macrocyclic polyketide that is synthesized by a Type I polyketide synthase. The genes gelA, gelB, and gelC encode for the polyketide synthase. The PKS...

multi-domains gene clusters, such as Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). Diverse studies show that grouping BGCs that share homologous...

Butyrolactol A is a polyketide featuring a tert-butyl group linked to a long hydrophobic carbon chain followed by 8 polyol groups. It is one of a number...

(2012). "Monophyly of some North American species of Ramalina and inferred polyketide synthase gene function". Botany. 90 (12): 1295–1307. doi:10.1139/b2012-097...

followed by the aromatization of the resulting pentaketide using a type III polyketide synthase. Next, THN undergoes geranylation or farnesylation at the C-4...

"Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds". Angewandte Chemie (International ed. In English). 52 (28):...

called dTDP-4-keto-6-deoxyglucose reductase. This enzyme participates in polyketide sugar unit biosynthesis. Yoshida Y, Nakano Y, Nezu T, Yamashita Y, Koga...

tongue or throat, severe dizziness, and trouble breathing Rifampicin is a polyketide belonging to the chemical class of compounds termed ansamycins, so named...

exposure and deters grazing animals with its bitter taste. Usnic acid is a polyketide biosynthesized via methylphloroacetophenone as an intermediate. Usnic...

Kinamycins are a group of bacterial polyketide secondary metabolites containing a diazo group. Kinamycins are known for their cytotoxicity and are considered...

and C, with type A being the major component. All types consist of a polyketide core with a perosamine sugar moiety. The variations occur at the end of...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

biosynthesis involves the construction of an aglycone core (by a type II polyketide synthase) to which one or more sugar residues are attached. Nogalamycin...

Wagoner, Ryan M.; Satake, Masayuki; Wright, Jeffrey L. C. (2014-06-16). "Polyketide biosynthesis in dinoflagellates: what makes it different?". Natural Product...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

a dimeric indole alkaloid with a hexadienoyl moiety originating from polyketide synthesis. Biosynthesis starts with two L-tryptophan molecules processed...

Kobayashi T (January 2014). "Hyaluromycin, a new hyaluronidase inhibitor of polyketide origin from marine Streptomyces sp". Marine Drugs. 12 (1): 491–507. doi:10...

Sterigmatocystin is a polyketide mycotoxin produced by certain species of Aspergillus. The toxin is naturally found in some cheeses. Sterigmatocystin is...

α-zearalenol, and β-zearalenol. Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid)...

Verrucosidin is a toxic pyrone-type polyketide produced by Penicillium aurantiogriseum, Penicillium melanoconidium, and Penicillium polonicum. Frisvad...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

chalcone synthase, which forms an intermediate chalcone-like compound via a polyketide folding mechanism that is commonly found in plants, The chalcone is subsequently...

Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. They are characterized by linear 32- or 34-carbon chains...

channelomics, electrophysiology, biomolecular interactions, cellular membranes, polyketides. Physics – negentropy, stochastic processes, and the development of new...

4-DAPG-producing strains of P. fluorescens. Of these genes, phlD encodes a type III polyketide synthase, representing the key biosynthetic factor for 2,4-DAPG production...

Herboxidiene is a polyketide molecule soluble in polar solvents such as water, ethanol, n-butanol and acetone but insoluble in non-polar solvents such...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Vederas, John C.; Hutchinson, C. Richard (21 May 1999). "Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis"...

Florova, G; Hale, V; Reynolds, K A (1998). "The shikimic acid pathway and polyketide biosynthesis". Journal of Industrial Microbiology and Biotechnology. 20...

found in the second cell wall of Gram-negative bacteria in general) Polyketides Aplysiatoxins Skin Lyngbya, Schizothrix, Planktothrix (Oscillatoria)...

fatty acid synthases are very much intertwined with that of polyketide synthases (PKS). Polyketide synthases use a similar mechanism and homologous domains...

grouped into four major biosynthetic classes: alkaloids, phenylpropanoids, polyketides, and terpenoids. Phytochemistry can be considered a subfield of botany...

cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides". Proceedings of the National Academy of Sciences of the United States...

for the biosynthesis of the α-ketopyrrole moiety, 5 for modular type I polyketide synthases for the spiroketal ring, 4 for the biosynthesis of 3-hydroxyanthranilic...

oxidative deselenation. In terms of natural product, isomigrastatin is the polyketide that contains the glutarimide. Biosynthesis of isomigrastatin starts with...

from Streptomyces verticillus ATCC15003 as a model for hybrid peptide-polyketide natural product biosynthesis". Journal of Industrial Microbiology & Biotechnology...

fluorescens, biosynthesis of phloroglucinol is performed with a type III polyketide synthase. The synthesis begins with the condensation of three malonyl-CoAs...

a new structural class of antibiotic and suggests a crossover between polyketide and non-ribosomal peptide biosynthetic pathways. Zwittermicin A is linear...

Stereochemistry and HIV-1 Inhibitory Activity of Integrasone, a Novel Fungal Polyketide. J. Nat. Prod. 2004, 67, 872-874. Du, L; Robles, AJ; King, JB; Powell...

monascorubinamine and rubropunctaimine. All six are produced with a combination of polyketide synthase (PKS) and fatty acid synthase (FAS) In the first step a hexekatide...

phosphate-dependent. The formation of butenyl-methyl-L-threonine is performed by a Bmt polyketide synthase that uses acetate/malonate as its starting material. Tolypocladium...

ciclosporin pathway with nonribosomal peptide synthase (NRPS) and/or polyketide synthase (PKS) being the key elements. The amino acid sequences of efrapeptins...

membrane-disturbing properties. The phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii. Lipid...

bacteria identified a new class of molecule containing a dimeric-tetracyclic polyketide backbone, which are now known as the hibarimicins. Hibarimicinone and...

Portentol is a complex polyketide first isolated in 1967 from the lichen Roccella portentosa and has since been extracted from various other lichen. It...

Maklamicin is a spirotetronate-class polyketide natural product. Isolated from Micromonospora sp. GMKU326 found in the root of Maklam phueak, it displays...

Bactobolin is a cytotoxic, polyketide-peptide and antitumor antibiotic with the molecular formula C14H20Cl2N2O6. Bactobolin was discovered in 1979. "Bactobolin"...

backbone structure of polyketides, but there are several methyl and oxygen groups that are not typical in traditional polyketide biosynthesis. Labelling...

yet[needs update] to be resolved. The molecule is produced in nature via a polyketide synthase pathway. Since 1996 the Nicolaou research group is involved in...

ISBN 978-3-946292-41-8. Retrieved January 27, 2022. Teng, Si-Qiong (2023). "Polyketides from the fungus Pochonia chlamydosporia and their bioactivities" [Phytochemistry]...

Hypericin is a carbopolycyclic compound derived from bisanthene with antidepressant properties, found in various Hypericum species, and is being studied...

encoded for by a 52 kb biosynthetic gene cluster (BGC) containing one polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS) hybrid (LbnA),...

required for Polyketide synthase (PKS) enzyme(s), to catalyze the a,b-dehydrogenation of acyl-CoA esters to make many natural products via Polyketide synthase...

Peucemycin is a polyketide produced by Streptomyces peucetius, a Gram-positive filamentous bacteria that also produces the anticancer compounds daunorubicin...

system is closely related to the machinery for building fatty acids and polyketides, hybrid compounds are often found. The presence of oxazoles or thiazoles...

Yonghong; Wang, Junfeng (2019). "Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301". Fitoterapia...

rings ("-cycl-") derivation ("-ine"). They are defined as a subclass of polyketides, having an octahydrotetracene-2-carboxamide skeleton and are known as...

14, 2016. Cox, Russell J.; Simpson, Thomas J. (2010). "Fungal Type I Polyketides". Comprehensive Natural Products II. p. 355. doi:10.1016/B978-008045382-8...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

metabolic pathways, such as fatty acid biosynthesis and degradation, polyketide biosynthesis and phenylacetic acid degradation. The HotDog domain superfamily...

Aurodox (X-5108, goldinomycin) is a naturally occurring polyketide antibiotic drug, first isolated in 1972 from Streptomyces goldiniensis. It is active...

including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier...

Originally thought to use 4 acetyl groups as feed compounds for the polyketide synthase that forms coniine, it is in fact derived from two malonyl and...

Leeper, Finian J.; Vederas, John C., eds. (2000). Biosynthesis Aromatic Polyketides, Isoprenoids, Alkaloids. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Gladiolin is a polyketide natural product produced by Burkholderia gladioli BCC0238. It was found to be a novel macrolide antibiotic which presented an...

E; Gill, J. H. (2007). "Citromycetins and bilains A-C: New aromatic polyketides and diketopiperazines from Australian marine-derived and terrestrial...

Hexacyclinol is a natural metabolite of a fungus, Panus rudis. Significant controversy surrounded its proposed structure until its total synthesis by John...

spiroverticillatus Unveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis". Journal of Biological Chemistry. 283 (42): 28607–28617...

synthase enzyme. The repeated action of this enzyme produces an 8-carbon polyketide intermediate that is cyclized. Barbatic acid's IUPAC name is...

Leeper, F. J.; Vederas, J. C. (5 September 2003). Biosynthesis: Polyketides and Vitamins. Springer Science & Business Media. p. 38. ISBN 978-3-540-69542-4...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Like other lichen depsides, erythrin is thought to arise from fungal polyketide biosynthesis. Its aromatic core corresponds to lecanoric acid, and heterologous...

Schierhorn, A; Svatos, A; Schröder, J; Schneider, B (2006). "A type III polyketide synthase from Wachendorfia thyrsiflora and its role in diarylheptanoid...

related to known natural products. It is believed to be synthesized through polyketide synthase and halogenase enzymes. Myxobacterial genomes typically have...

acid 3-Methylsalicylic acid Staunton, James; Weissman, Kira J. (2001). "Polyketide Biosynthesis: A Millennium Review". Natural Product Reports. 18 (4): 380–416...

congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424...

biochemically synthesized via the acetyl-polymalonyl pathway (also known as polyketide pathway), while only a few originate from the mevalonate and shikimate...

A3(2), and for developing the programming of the pervasive process of polyketide synthesis". In 2002, he co-authored the sequencing of the S. coelicolor...

synthesized by some strains of L. reuteri by a 9-gene cluster, containing a polyketide synthase (PKSs) and a non-ribosomal peptide synthetase (NRPS). Gänzle...

The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)...

"Synthesis of Macrosporin and Related 9,10-Anthraquinones by Biomimetic Polyketide Aromatization and Cyclization of 6-Benzylresorcylates". European Journal...

China. It was also later found in Penicillium urticae. It is a linear polyketide very similar in structure to tautomycin, both of which contain a unique...

Santos, L. S.; Rodrigues Filho, E.; Ferreira, I. C. P. (2013). "Active polyketides isolated from Penicillium herquei". Anais da Academia Brasileira de Ciências...

flavors in hops can be accounted for by acids composed of prenylated polyketides (a group of secondary metabolites), which highly impact the taste of...

Ten, L. N.; Mukhamedzhanov, S. Z.; Dzhavakhiya, V. G. (1988-07-01). "Polyketide exometabolites of the causative agent of rice blast and their role in...

bacteria and eukaryotes with roles in the synthesis of fatty acids, polyketides, and nonribosomal peptides. The protein encoded by this gene is similar...

synthase (EC 2.3.1.170) is an enzyme that catalyzes the synthesis of the polyketide, isoliquiritigenin, from one unit of coumaroyl-CoA and three of malonyl-CoA...

Kito K, Yoshida S, Kanoh K, Shizuri Y, Kusumi T (March 2008). "Three new polyketide-terpenoid hybrids from Penicillium sp". Organic Letters. 10 (5): 845–8...

(1999). "Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis". Nat. Struct. Biol. 6 (8): 775–784. doi:10.1038/11553. PMID 10426957...

Its end product, 3-amino-5-hydroxybenzoate, serves as an initiator for polyketide synthases in the biosynthesis of ansamycins. Floss and coworkers identified...

poly-β-keto chains, which are subsequently converted into various polyketides. The polyketide class of natural products has diverse structures and functions...

antitumor activity. The biosynthesis of azinomycin B includes a type 1 polyketide synthase and several nonribosomal peptide synthetases. Zhao, Qunfei, Qingli...

Biosynthesis, and Rational Engineering of Novel Enterocin and Wailupemycin Polyketide Analogues". Metabolomics Tools for Natural Product Discovery. Methods...

maps to a single amino acid substitution (R644W) in an uncharacterized polyketide synthase (MuPKS) gene. When the MuPKS gene is expressed in yeast, yellow...

department conducts research in areas including bacterial cooperation, polyketide synthase clusture, antibiotic resistance, Apoptosis, phosphate solubilisation...

cloning, functional expression, and site-directed mutagenesis of two polyketide synthases". The Plant Journal. 34 (6): 847–855. doi:10.1046/j.1365-313X...

from the original on 7 November 2012. Vedas JC (2000). Biosynthesis: polyketides and vitamins. Berlin [u.a.]: Springer. p. 52. ISBN 978-3-540-66969-2...

Cambridge, UK. Her Master's project, working with Peter F. Leadlay, was on polyketide syntheses, enzymes that are involved in the synthesis of many antibiotics...

Streptomyces, and for developing the programming of the pervasive process of polyketide synthesis" 1997 — Kenneth Holmes "in recognition of his achievements in...

majority of the core structure is produced in vivo through iterative type I polyketide synthases. This structure produced is the earliest intermediate in the...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

refers to compounds derived from the shikimate/phenylpropanoid and/or the polyketide pathway, featuring more than one phenolic unit and deprived of nitrogen-based...

number of 13805 genes. The S. lacrymans genome encodes six annotated polyketide synthases (PKS1-PKS6), 15 nonribosomal peptide synthetases (NPS1-NPS4...

predicted that jamaicamide A's biosynthetic pathways are from a hybrid polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) assembly units. Jamaicamide...

Lacey, E; Gill, JH (2007). "Citromycetins and bilains A-C: New aromatic polyketides and diketopiperazines from Australian marine-derived and terrestrial...

watched precursor.[unreliable source?] Olivetol is biosynthesized by a polyketide synthase (PKS)-type reaction from hexanoyl-CoA and three molecules of...

activities of a gene cluster, which includes two separate iterative type I polyketide synthase (PKS) and deoxy sugar biosynthetic pathways. The first type I...

Patulin is an organic compound classified as a polyketide. It is named after the fungus from which it was isolated, Penicillium patulum. It is a white...

acetyl-CoA, two methylmalonyl-CoA and three malonyl-CoA molecules with polyketide synthase (PKS). Then the product undergoes Diels-Alder Cyclization, chain...

conserved, iterative type I polyketide synthase (PKS) pathway Sequencing of enediyne gene clusters has confirmed the polyketide origin of the enediyne core...

Gephyronic acid is a polyketide that exists as an equilibrating mixture of structural isomers. In nature, gephyronic acid is produced by slow growing myxobacterium:...

cluster containing one nonribosomal peptide synthase (NRPS) module and one polyketide synthase (PKS) module. The single PKS module functions in a non-canonical...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Curacin A is a hybrid polyketide synthase (PKS)/nonribosomal peptide synthase (NRPS) derived natural product produced isolated from the cyanobacterium...

Brett A. (4 June 2012). "Genetic Diversity, Morphological Uniformity and Polyketide Production in Dinoflagellates (Amphidinium, Dinoflagellata)". PLOS ONE...

Chlorophyceae and Rhodophyceae. Observed biogenic products include polyketides, amides, alkaloids, fatty acids, indoles and lipopeptides. For example...

these poylenes as localized at the wounded area. Two putative alleles of polyketide genes were identified, referred to as PPS1 and PPS2. QRT-PCR monitoring...

intermediate to most if not all tetrahydroxanthones. The nsr cluster is a polyketide synthase gene responsible for the biosynthesis of neosartorin in A. novofumigatus...

such as actinomycin-D Phenazines Natural phenols (including flavonoids) Polyketide Terpenes and terpenoids, including steroids Tetrapyrroles. Enzymes and...

Möllmann, U; Gräfe, U; Hertweck, C (19 September 2005). "Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance"...

via Transfer Hydrogenative Allylation, Crotylation, and Propargylation: Polyketide Construction beyond Discrete Allyl- or Allenylmetal Reagents". Journal...

Ironomycin is a derivative of salinomycin and potent small molecule against persister cancer stem cells, that is under preclinical evaluation by SideROS...

Fischbach MA, Walsh CT (August 2006). "Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms"...

pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis. The crystal structure of RmlC from Methanobacterium...

pareirubrine A and B), colchicine, colchicone and others. Tropolone arises via a polyketide pathway, which affords a phenolic intermediate that undergoes ring expansion...

Citreorosein is a polyketide made by Penicillium that has antimicrobial activity. Marinho, A. M.; Marinho, P. S.; Santos, L. S.; Rodrigues Filho, E; Ferreira...

ring-closing metathesis facilitating macrocyclization in alkaloids and polyketides in natural product synthesis, and the Shell Higher Olefin Process (SHOP)...

Jensen, Paul R.; Fenical, William (2007). "Saliniketals A and B, Bicyclic Polyketides from the Marine Actinomycete Salinispora arenicola". Journal of Natural...

specific to parrots. In parrots, psittacofulvins are synthesized by a polyketide synthase enzyme that is expressed in growing feathers. They consist of...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

malonyl-CoA extenders to the hexanoate to form the C20 polyketide compound. The PKS folds the polyketide in a particular way to induce cyclization to form...

"Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase". Gene. 151 (1–2): 1–10. doi:10.1016/0378-1119(94)90625-4. PMID 7828855...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

of Michigan, where he broadened his expertise in the biosynthesis of polyketides and non-ribosomal peptides. His residency involved studying how six Bacillus...

Phytotoxins: Mode of Action, Regulation, and Biosynthesis by Peptide and Polyketide Synthetases". Microbiology and Molecular Biology Reviews. 63 (2): 266–292...

factors in the production of cercosporin. Cercosporin is biosynthesized via polyketide synthases, and there are several genes that have been found responsible...

(January 2006). "The Complete Biosynthetic Gene Cluster of the 28-Membered Polyketide Macrolactones, Halstoctacosanolides, from Streptomyces halstedii HC34"...

inhibitors, including peptide inhibitors, polyphenolic phytochemicals, polyketides, organotin compounds, polyenic α-pyrone derivatives, cationic inhibitors...

seems to encode 60 PilE genes putatively involved in pilus assembly, polyketide synthesis, non-ribosomal peptide synthesis and many other still undiscovered...

of Cambridge in 2000 to study the chemistry and molecular biology of polyketide biosynthesis in the research group of Professors Jim Staunton (FRS) and...

Matthias Platzer; Nobuhiro Fusetani; Shigeki Matsunaga (2004). "Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge...

Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product". Molecular Cell. 16 (6): 881–91. doi:10.1016/j.molcel...

at Columbia University. He is known for his non-aldol approaches to polyketides. Leighton was born in New Haven, Connecticut. As an undergraduate at...

genes involved in fatty acid metabolism, with 39 of these involved in the polyketide metabolism generating the waxy coat. Such large numbers of conserved genes...

chemical industry. A major platform for creation of new chemicals is the polyketide biosynthetic pathway, which generates chemicals containing repeated alkyl...

Gloer, J. B.; Wicklow, D. T.; Dowd, P. F. (1998). "New p-terphenyl and polyketide metabolites from the sclerotia of Penicillium raistrickii". Journal of...

Lindequist, Ulrike (2024). Natural Poisons and Venoms: Plant Toxins: Polyketides, Phenylpropanoids and Further Compounds. De Gruyter STEM. Berlin; Boston:...

green-black colour. Thiophanic acid is biosynthesised from a single linear polyketide chain which cyclizes to form the characteristic xanthone structure. The...

complex natural products, including alkaloids, C-aryl glycosides, and polyketides that exhibit useful biological activities. In the area of bioorganic...

"Identification and characterization of a gene cluster for synthesis of the polyketide antibiotic 2,4-diacetylphloroglucinol from Pseudomonas fluorescens Q2-87"...

antibiotics having a yellow color. The natural route to synthesis includes polyketide synthase components. Rimocidin Filipin Candicin Hamycin Perimycin Dermostatin...

pathway. However, in Streptomyces coelicolor, FabD is involved in FAS and polyketide synthase pathways. In both cases, the structures and active sites are...

prediction for genetically encoded nonribosomal peptides and type I and II polyketides. SIM (Statistically based sequence similarity) method, such as FASTA...

"Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence". Molecular & General Genetics...

enzymes known as polyketide synthases (PKSs), which are widely found in Euglenoids, as well as other algae that produce polyketides. The mechanism by...

(December 1997). "Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis". Journal of Bacteriology....

A; Myles, DC; Zhou, Y (2003). "Conformation-activity relationships in polyketide natural products: a new perspective on the rational design of epothilone...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

dehydrocurvularin by Alternaria cinerariae: Comparison of stereochemistry of polyketide and fatty acid enoyl thiol ester reductases". Journal of the American...

K.; Trauner, D. Mapping the Chemistry of Highly Unsaturated Pyrone Polyketides. Synlett 2006, 2295-2316. Milne, B. F.; Long, P. F.; Starcevic, A.; Hranueli...

identify a unique toxin biosynthesis gene cluster in P. australis, including polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) related genes...

Trichokonins are peptaibols that exhibit antimicrobial property. Other polyketides reportedly isolated from T. koningii are Trichodermaketones A-D, 7-O-Methylkoninginin...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

biosynthesizing tricin, there is first stepwise addition of malonyl-CoA via the polyketide pathway and p-coumaroyl-CoA via the phenylpropanoid pathway. These additions...

August 1999). "Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis". Proceedings...

Spectinabilin is a nitrophenyl-substituted polyketide metabolite. It was first isolated from crude streptovaricin complex produced by Streptomyces spectabilis...

few endogenous secondary metabolites. Transformed types can produce: polyketide synthase-derived 1,3,6,8-tetrahydroxynaphthalene, alternapyrone, and...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Kharel, MK; Thorson, JS (Jan 17, 2014). "Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15". Organic Letters. 16 (2): 456–9. doi:10...

accumulated in the eggs of most Paederus females Piel, Jörn (2002). "A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial...

Mutase in the Biosynthesis of the Unique Starter Unit of the Macrolactam Polyketide Antibiotic Vicenistatin". The Journal of Antibiotics. 58 (7): 468–72....

between the C-terminus and a 𝛽-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. Mirabamide G is a fusion...

Jay Thomas (2012). Engineering of Biosynthetic Pathways to the Type II Polyketides Frenolicin B and A-74528. Stanford University. ApSimon, John (16 April...

PMID 12569104. Kopp F, Marahiel MA (August 2007). "Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis". Natural Product Reports. 24 (4):...

is a 16-membered polyketide macrolactone with a methylthiazole group connected to the macrocycle by an olefinic bond. The polyketide backbone was synthesized...

Acyl Carrier Protein-Ketoreductase Interaction in trans-Acyltransferase Polyketide Synthases (with Munro Passmore, Angelo Gallo and Matthew Jenner, 2021)...

(mcy) that contains 6 large (over 3 kb) genes that encode proteins with polyketide synthase activity, nonribosomal peptide synthase activity (mcyA-E and...

"Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation". Organic Letters. 15 (6): 1278–1281. doi:10...

JS "Stereochemical diversity through cyclodimerization: Synthesis of polyketide-like macrodiolides." Org Lett 2003, 5:2149-2152. Medina-Franco, J.L.;...

of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens". Proceedings of the National Academy...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates. Methods in Enzymology. Vol. 459. pp...

Miyanouchi, Koji (April 25, 2012). "Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura". The Journal of Antibiotics...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

(2012). "Monophyly of some North American species of Ramalina and inferred polyketide synthase gene function". Botany. 90 (12): 1295–1307. doi:10.1139/b2012-097...

longibrachiatum produces many secondary metabolites including: peptaibols, polyketides, pyrones, terpenes and diketopiperazine-like compounds. Trichoderma longibrachiatum...

the backbone is elongated by six units. The leinamycin hybrid peptide-polyketide carbon backbone intermediate is then cyclized by the thioesterase domain...

N/A Sponge Tripeptide Microtubules 0/3 Cancer Bryostatin 1 N/A Bryozoa Polyketide Protein Kinase C 0/38 Cancer, Alzheimers Pseudopterosins N/A Soft Coral...

synthase (EC 2.3.1.177) is an enzyme that catalyzes a biosynthesis of the polyketide, 3,5-dihydroxybiphenyl, from one unit of benzoyl-CoA and three of malonyl-CoA...

-G.; Kharel, M.K.; Thorson, J.S. (2014). "Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15". Org. Lett. 16 (2): 456–459. doi:10.1021/ol4033418...

CpaS is the first enzyme in the biosynthetic pathway and is a hybrid polyketide synthase- nonribosomal peptide synthetase (PKS-NRPS). It uses the precursors...

type of aromatic ring compound normally proceeds via the shikimate and polyketide pathways; however, the production of macrophomic acid by macrophomate...

summarized below. Carbonyl allylation has been employed in the synthesis of polyketide natural products and other oxygenated molecules with a contiguous array...

cloned a gene for polyketide synthase from Solorina crocea and transferred it to the filamentous fungus Aspergillus oryzae. Lichen polyketides are of general...

Wagoner, Ryan M.; Satake, Masayuki; Wright, Jeffrey L. C. (2014-06-16). "Polyketide biosynthesis in dinoflagellates: what makes it different?". Natural Product...

A; Ahmad, S; Ali, N (2014). "Penicillium verruculosum SG: A source of polyketide and bioactive compounds with varying cytotoxic activities against normal...

group. Macroketones form the central rings systems of some synthetic polyketide antibiotics. Anquetin G, Horgan G, Rawe S, Murray D, Madden A, MacMathuna...

gene that is highly similar to the beta-keto-acyl synthase domain of polyketide synthase genes from other fungi". Letters in Applied Microbiology. 25...

Callystatin A is a polyketide natural product from the leptomycin family of secondary metabolites. It was first isolated in 1997 from the marine sponge...

tuberculosis mutations in the rpoB gene can significantly upregulate polyketide synthase, potentially indicating increased production of phthiocerol dimycocerosate...

pathways which require a type I Fatty Acid Synthase (FAS) construct and a Polyketide Synthase-like (PKS-like) machinery (a.k.a. PUFA synthase), respectively...

March 2023. Thanabalasingam, D (March 27, 2023). "Oryzanigral: a new polyketide from an endophytic fungus Nigrospora oryzae isolated from Coccinia grandis"...

Mayamycin is a cytotoxic polyketide isolated from a marine Streptomyces. Schneemann, I; Kajahn, I; Ohlendorf, B; Zinecker, H; Erhard, A; Nagel, K; Wiese...

synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis". Journal of the American...

outdated. Marine bacteria and the microalgae Schizochytrium use an anerobic polyketide synthase pathway to synthesize DHA. DHA can be metabolized into DHA-derived...

Wang, Clay C. C. (16 May 2012). "Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans". Journal of the American Chemical Society...

being identified 60 years ago. Antimycins are synthesised by a hybrid polyketide synthase (PKS)/non-ribosomal peptide synthase (NRPS). Lethal doses in...

Fallacinol (teloschistin) is an organic compound in the structural class of chemicals known as anthraquinones. It is found in some lichens, particularly...

biosynthetic gene cluster. All producing species share a single non-reducing polyketide synthase (classified as PKS16) flanked by only two conserved neighbouring...

Malonyl-CoA (important in chain elongation in fatty acid biosynthesis and polyketide biosynthesis) Succinyl-CoA (used in heme biosynthesis) Hydroxymethylglutaryl-CoA...

grouped into four major biosynthetic classes: alkaloids, phenylpropanoids, polyketides, and terpenoids. Active constituents of the majority of psychoactive...

species of the genus Penicillium. Penicillium antarcticum produces the polyketide compounds antarone A and antarone B. It was originally discovered on the...

genome predicted 42 biosynthetic gene clusters, including 21 predicted polyketide clusters. The same study discussed prenyltransferase genes in lichen-forming...

of two 16:4(n-3) acyl chains by OleABCD yields hentriacontanonaene. A polyketide-like pathway responsible for the production of eicosapentaenoic acid provides...

Kumari, Rashmi; Singh, Priya (2014-07-25). "Modification of Rifamycin Polyketide Backbone Leads to Improved Drug Activity against Rifampicin-resistant...

shared uniquely across the Teloschistales. Phylogenetic analyses of fungal polyketide synthases (PKSs) reveal a consistent grouping of genes, hinting at a shared...

derivatives are known. They arise via terpene-derived precursors or polyketides. Oxygenation of decalin gives the tertiary hydroperoxide, which rearranges...

of a 4'-phosphopantetheinyl moiety from coenzyme A, as in fatty acid, polyketide, non-ribosomal peptide and leucine biosynthesis retinylidene Schiff base...

can be synthesized in berry plants through the shikimate pathway and polyketide synthase (PKS) III. The shikimate pathway is a biosynthetic pathways that...

"Total synthesis of long DNA sequences: Synthesis of a contiguous 32-kb polyketide synthase gene cluster". PNAS. 101 (44): 15573–15578. Bibcode:2004PNAS...

AD, D'Auria JC, Barry CS (2018). "Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization". Nature Communications. 9 (1):...

numerous cyclopropane synthases; Condensation reaction catalysed by the polyketide synthase Pks13 between the α-branch and the meromycolate chain before...

Joshawna K.; Powell, David H.; Butcher, Rebecca A. (October 2016). "A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival". Nature...

The biosynthesis of phoslactomycin belongs to type I polyketide synthase (PKS). A polyketide is are characterized by a macrocyclic lactone and is produced...

alkaloids, amino acids, peptides, proteins, carbohydrates, lipids, enzymes, polyketides, terpenoids, and fatty acids. Secretion can be constitutive, in which...

to their structural differences involving the halogen atom. A hybrid polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) pathway is most likely...

hormone Methylprednisolone acetate, a corticosteroid Verrucosidin, a fungal polyketide This set index page lists chemical structure articles associated with...

purpureus produces a variety of bioactive compounds, including a family of polyketides known as monacolins. Among these, monacolin K is chemically identical...

(+)-Discodermolide is a polyketide natural product found to stabilize microtubules. (+)-discodermolide was isolated by Gunasekera and his co-workers at...

orsellinic acid and protoilludane sesquiterpene alcohols via esterification. A polyketide synthase gene, termed ArmB, was identified in the genome of the fungus...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases. Microbiology and Molecular Biology Reviews 63, 266-292 Tourte...

biosynthesis of the dynemicin enediyne core to be catalyzed by an enediyne polyketide synthase (PKSE) similar to that employed in calicheamicin biosynthesis...

sp. nov. and Its Secondary Metabolite Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide Compounds". Microorganisms. 8 (3): 370. doi:10...

crops such as wheat, barley, oats, rye, and corn. Chemically, they are polyketides that are also derived from amino acids. Some members of the class, particularly...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

(2011-07-20). "Nongenetic Reprogramming of a Fungal Highly Reducing Polyketide Synthase". Journal of the American Chemical Society. 133 (28): 10990–10998...

VS; Telliez, JB (August 2005). "Phaeochromycins A-E, anti-inflammatory polyketides isolated from the soil actinomycete Streptomyces phaeochromogenes LL-P018"...

N-oxygenase (MgoC), a nonribosomal peptide synthetase (NRPs) (mgoA), and a polyketide cyclase/dehydrase or lipid transporter (MgoD). The mgo operon is a positive...

of Amphidinols: First Evidence of Glycolate as a Starter Unit in New Polyketides from Amphidinium carterae". Marine Drugs. 15 (6): 157. doi:10.3390/md15060157...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Penicillium patulum, which is involved in the biosynthesis of a polyketide antibiotic; polyketide antibiotic synthase enzyme systems; Emericella nidulans multifunctional...

K.; Laue, E. D.; Staunton, J. (1988). "Biosynthesis of palitantin, a polyketide metabolite of Penicillium brefeldianum: 13C n.m.r. Assignment and incorporation...

Hertweck C (December 2014). "Biosynthesis of antifungal and antibacterial polyketides by Burkholderia gladioli in coculture with Rhizopus microsporus". Mycoses...

Ybt synthesis occurs by a mixed nonribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) mechanism. Several enzymes, most notably the HMWP2-HMWP1complex...

followed by the aromatization of the resulting pentaketide using a type III polyketide synthase. Next, THN undergoes geranylation or farnesylation at the C-4...

biosynthesis of Pseurotin A was predicted by deletion and overexpression of polyketide synthase nonribosomal peptide synthetase hybrid enzyme gene, PsoA. While...

S. E.; Vederas, J. C. (1987). "Biosynthesis of multicolosic acid, a polyketide metabolite from Penicillium multicolor: Occurrence of large 18O-induced ...

polymerase, amidohydrolase, carboxymunconolacton decarboxylase family protein, polyketide cyclase, spirocyclase AveC family protein, TobH protein, UDP-N-acetylmuramate–L-alanine...

virulence genes regulated by PhoP are involved in the biosynthesis of polyketide-derived acyltrehaloses (DAT, PAT) and sulfolipids (SL), which are first-line...

Molvizarin is a cytotoxic acetogenin derivate with the molecular formula C35H62O7 which has been isolated from the bark of the plant Annona cherimolia...

resistance may be better understood by genome-level investigation. The polyketide synthase gene atX produces 6-Methylsalicylic acid in A. terreus. Aspergillus...

reductase (CHR) and NADPH as a co-factor, the oxygen function of the polyketide intermediate is reduced and eliminated as water prior to cyclization,...

and the use of allylic stannanes for the stereocontrolled synthesis of polyketide chains. Throughout his career, he pursued the total synthesis of complex...

units of coenzyme A and three of carbon dioxide are byproducts of this polyketide synthesis which leads to rutacridone. The enzyme was characterised from...

bacteria, particularly vancomycin-resistant bacteria. Streptogramin A is a polyketide in nature, but contains some amino acid components as well. Its gene cluster...

biosynthesis has not been fleshed out, precoccinelline is thought to be of polyketide origin. The hypothesized biosynthesis involves condensation of six acetates...

"Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani"...

which plays an important role in both Nucleotide sugar metabolism and polyketide sugar unit biosynthesis. Petidoglycan biosynthesis also require murG,...

Epothilones: The EpoC Subunit and Reconstitution of the EpoA-ACP/B/C Polyketide and Nonribosomal Peptide Interfaces". Biochemistry. 41 (17): 5685–5694...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

lactones, coumarins); biochemists according to their biosynthetic origins (polyketides, amino acid-derived, etc.); physicians by the illnesses they cause (e...

the organism that code for the respective natural product. A trans-AT polyketide synthase cluster, designated as the Psy cluster, contained two large groups...

long-chain-acyltransferase EC 2.3.1.289: aureothin polyketide synthase system EC 2.3.1.290: spectinabilin polyketide synthase system EC 2.3.1.291: sphingoid base...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

Lindequist, Ulrike (2024). Natural Poisons and Venoms: Plant Toxins: Polyketides, Phenylpropanoids and Further Compounds. De Gruyter STEM. Berlin, Boston:...

to engineer FAS for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach . They reprogrammed...

known as ZK-EPO, belongs to the epothilones, which are derived from polyketides. Sagopilone is a 16-bond macrolide structure, a macrocycle with inner...

"Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite". Journal of the American...

L, Zhu T, Liu H, Fang Y, Zhu W, Gu Q (December 1, 2008). "Cytotoxic Polyketides from a Marine-derived Fungus Aspergillus glaucus". Journal of Natural...

"Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani"...

Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide". Journal of the American Chemical Society. 140 (22): 6991–6997. doi:10...

from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes". Gene. 227 (2): 125–35. doi:10.1016/s0378-1119(98)00618-0...

cell collapse. Additionally, aggressive strains of the fungus secrets polyketides such as botcinic acid that exhibit phytotoxic and antifungal activity...

applied to. These include (but are not limited to): terpenes, alkaloids, polyketides. and polyethers. Total synthesis targets are sometimes referred to by...

Mensacarcin is a highly oxygenated polyketide first isolated from soil-dwelling Streptomyces bottropensis bacteria. The molecule is a secondary metabolite...

depsipeptide Didemnin is governed by a hybrid non-ribosomal peptide synthetase-polyketide synthetase (NRPS-PKS) pathway. The didemnin mega-synthetase consists of...

participates in tetracycline biosynthesis and biosynthesis of type ii polyketide products. Behal V (1987). "The tetracycline fermentation and its regulation"...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

biodegrade the explosive compound 2,4,6-trinitrotoluene (TNT). A number of polyketide-type antioxidative compounds, cyathusals A, B, and C, and pulvinatal have...

glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, and polyketides (derived from condensation of ketoacyl subunits); and sterol lipids and...

thiazolines and one thiazole, and a highly oxygenated and methylated C-15 polyketide unit. The hoiamides are stereochemically complex structures, with hoiamide...

Antimycins are produced by a non-ribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) assembly complex which acts as an assembly line for antimycin...

Qiu, Rong-guo; Tang, Li (26 April 2013). "Identification of the Post-Polyketide Synthase Modification Enzymes for Fostriecin Biosynthesis in". Journal...

(2014) Notoparmelia testacea and N. subtestacea contain testacein, a polyketide-sesquiterpene compound that has also been found in the lichen genera Pyxine...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

reaction between hexanoyl-CoA and malonyl-CoA, catalyzed by type III polyketide synthase (PKS), the product is then used to form olivetolic acid. After...

backbone carbon units of betaenone B are known to be synthesized via the polyketide synthesis (PKS) pathway. The backbone is synthesized through the addition...

B. A., Aasen, A. J. and Robeson, D. J., Studies on the Mechanism of Polyketide-derived Biosynthesis of Deoxyradicinin and Related Metabolites of Alternaria...

Julia; Grininger, Martin; Boles, Eckhard (2020). "Substrate promiscuity of polyketide synthase enables production of tsetse fly attractants 3-ethylphenol and...

Onaka, Hiroyasu (2010-08-06). "Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton from Streptomyces sp". Organic Letters...

worked on other organocatalyzed transformations. Inspired by natural polyketide synthases—which use malonic acid half thioesters (MAHTs) as thioester...

on the biosynthesis of natural products, particularly terpenoids and polyketides. Lewis C. Cantley (b. 1949). American cell biologist and biochemist at...

Homoanatoxin-a in the Cyanobacterium Oscillatoria PCC 6506 Occurs on a Modular Polyketide Synthase Initiated by l-Proline". Journal of the American Chemical Society...

PMID 10590309. Kopp F, Marahiel MA (August 2007). "Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis". Nat Prod Rep. 24 (4): 735–49....

Actinobacterium Kibdelosporangium sp. MJ126-NF4, Producer of Type II Polyketide Azicemicins, Using Illumina and PacBio Technologies". Genome Announcements...

Bullatacin is a bis(tetrahydrofuranoid) fatty acid lactone found in some fruits from Annonaceae family. It is a member of the class of compounds known...

Xenocylindrosporium Crous & Verkley (2009) – 1 sp. Sesquiterpenes and polyketides metabolites are found in Picea rubens endophytes Phaemoniella. Kraus...

J.M.; Molnar, I. (2004). "Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosumvSo ce26 in Streptomyces...

chain reaction-analyses suggested that the organism lacks the DNA for polyketide synthesis, the type of toxins associated with most toxic dinoflagellates...

"Metabolic diversity of lichen-forming ascomycetous fungi: culturing, polyketide and shikimate metabolite production, and PKS genes". Natural Product Reports...

Press. p. 205. ISBN 978-1-4822-8215-3. Zhou, Jiaju (23 September 2019). Polyketides and Steroids. Walter de Gruyter GmbH & Co KG. p. 131. ISBN 978-3-11-065392-2...

Proteins Glycoproteins & proteoglycans Chlorophylls MEP MVA Acetyl -CoA Polyketides Terpenoid backbones Terpenoids & carotenoids (vitamin A) Cholesterol...

aminocoumarins in that they are composed of both aminocoumarins and a polyketide element. They also inhibit DNA gyrase's ability to bind to DNA instead...

"Structural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine sponges". Natural Product Reports. 33 (7): 861–880...

Cleveland Clinic. 1948 Tetracycline Tetracycline is a broad-spectrum polyketide antibiotic indicated for use against many bacterial infections. It is...

Jeffrey M.; Tallarico, John A.; Schirle, Markus (2020-06-22). "Manumycin polyketides act as molecular glues between UBR7 and P53". Nature Chemical Biology...

Skepper†, Colin K.; Molinski, Tadeusz F. (May 15, 2009). "A Tetrachloro Polyketide Hexahydro-1H-isoindolone, Muironolide A, from the Marine Sponge Phorbas...

Hirata, A.; Horinouchi, S. (2006). "Phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii"....

Lacey, E; Gill, JH (2007). "Citromycetins and bilains A-C: New aromatic polyketides and diketopiperazines from Australian marine-derived and terrestrial...

Daloze; S. De Groote; J. B. Fernandes; R. W. Van Soest (3 July 1998). "New polyketides from the sponge Plakortis sp". Journal of Natural Products. 61 (8): 1038–1042...

two triple bonds, and their biosynthesis is distinct from other known polyketide and fatty-acid synthesis paradigms. The enediyne PKS, PKSE, from S....

Lichen-Forming Fungi: Lichen Substances, Chemosyndromic Variation and Origin of Polyketide-Type Metabolites (Biosynthetic Pathways)". In Upreti, Dalip Kumar; Divakar...