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join together DNA fragments. However, many common names use the term "synthetase" or "synthase" instead, because they are used to synthesize new molecules...

ACV synthetase (ACVS, L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine synthetase, N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase, EC 6.3.2.26)...

An aminoacyl-tRNA synthetase (aaRS or ARS), also called aminoacyl-tRNA ligase, is an enzyme that attaches the appropriate amino acid onto its corresponding...

Glutamine synthetase (GS) (EC 6.3.1.2) is an enzyme that catalyzes the condensation of glutamate and ammonia to form glutamine: Glutamate + ATP + NH3 →...

Glutathione synthetase (GSS) (EC 6.3.2.3) is the second enzyme in the glutathione (GSH) biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine...

Polyprenyl synthetases are a class of enzymes responsible for synthesis of isoprenoids. Isoprenoid compounds are synthesized by various organisms. For...

Acetyl-CoA synthetase (ACS), also commonly known as Acetate—CoA ligase or acetyl activating enzyme, is an enzyme (EC 6.2.1.1) of the ligase class of enzymes...

Acyl-CoA synthetases, also known as acyl-CoA ligases, are enzymes that "activate" fatty acids by thioesterification to coenzyme A. It represents the initial...

S-Adenosylmethionine synthetase (EC 2.5.1.6), also known as methionine adenosyltransferase (MAT), is an enzyme that creates S-adenosylmethionine (also...

interstitial lung disease, and antibodies directed against various synthetases of aminoacyl-transfer RNA. Other common symptoms include mechanic's hands...

Glutathione synthetase deficiency (GSD) is a rare autosomal recessive metabolic disorder that prevents the production of glutathione. Glutathione helps...

biosynthesis that interconverts UTP and CTP. CTP (cytidine triphosphate) synthetase catalyzes the last committed step in pyrimidine nucleotide biosynthesis:...

Argininosuccinate synthase or synthetase (ASS; EC 6.3.4.5) is an enzyme that catalyzes the synthesis of argininosuccinate from citrulline and aspartate...

Polyprenylpyrophosphate synthetase may refer to: All-trans-octaprenyl-diphosphate synthase, an enzyme All-trans-decaprenyl-diphosphate synthase, an enzyme...

Succinyl coenzyme A synthetase (SCS, also known as succinyl-CoA synthetase or succinate thiokinase or succinate-CoA ligase) is an enzyme that catalyzes...

Asparagine synthetase (or aspartate-ammonia ligase) is a chiefly cytoplasmic enzyme that generates asparagine from aspartate. This amidation reaction is...

Acetylglutamate synthetase may refer to: Amino-acid N-acetyltransferase Glutamate N-acetyltransferase This disambiguation page lists articles associated...

Carbamoyl phosphate synthetase catalyzes the ATP-dependent synthesis of carbamoyl phosphate from glutamine (EC 6.3.5.5) or ammonia (EC 6.3.4.16) and bicarbonate...

Carbamoyl phosphate synthetase I deficiency (CPS I deficiency) is an autosomal recessive metabolic disorder that causes ammonia to accumulate in the blood...

probably due to mutations in the organism's wild-type isoleucyl-tRNA synthetase (IleS). In E. coli IleS, a single amino acid mutation was shown to alter...

synthetase) is an enzyme (EC 6.2.1.3) of the ligase family that activates the oxidation of complex fatty acids. Long chain fatty acyl-CoA synthetase catalyzes...

MurE synthetase may refer to: D-alanine—D-alanine ligase, an enzyme UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diamino-pimelate ligase, an enzyme This...

Carbamoyl phosphate synthetase I (CPS1 or CPSI) is a ligase enzyme located in the mitochondria involved in protein metabolism and the subsequent production...

5,10-Methenyltetrahydrofolate synthetase deficiency (MTHFS deficiency) is a rare neurodevelopmental disorder caused by mutations affecting the MTHFS gene...

nonribosomal peptide synthetases, which, unlike the ribosomes, are independent of messenger RNA. Each nonribosomal peptide synthetase can synthesize only...

1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem. 270...

Porphyria (/pɔːrˈfɪriə/ or /pɔːrˈfaɪriə/) is a group of disorders in which substances called porphyrins build up in the body, adversely affecting the skin...

Holocarboxylase synthetase (biotin—(propionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)), also known as protein—biotin ligase, is a family of enzymes...

Acyl-CoA synthetase family member 3 (ACSF3) is a mitochondrial enzyme encoded by the ACSF3 gene. It is required for the degradation of malonic acid and...

Holocarboxylase synthetase deficiency is an inherited metabolic disorder in which the body cannot use biotin – a B vitamin – effectively. This disorder...

synthetase is an enzyme that in humans is encoded by the GARS1 gene. This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that...

Argininosuccinate synthetase is an enzyme that in humans is encoded by the ASS1 gene. The protein encoded by this gene catalyzes the penultimate step of...

Glutamine–tRNA ligase or glutaminyl-tRNA synthetase (GlnRS) is an aminoacyl-tRNA synthetase (aaRS or ARS), also called tRNA-ligase. is an enzyme that attaches...

Tryptophanyl-tRNA synthetase, cytoplasmic is an aminoacyl-tRNA synthetase enzyme that attaches the amino acid tryptophan to its cognate tRNA. In humans...

Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene. This gene encodes a cytosolic leucine-tRNA synthetase, a member...

Alanyl-tRNA synthetase domain containing 1 is a protein in humans encoded by the AARSD1 gene. GRCh38: Ensembl release 89: ENSG00000266967 – Ensembl, May...

Guanosine monophosphate synthetase, (EC 6.3.5.2) also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate. In...

Tryptophan synthase or tryptophan synthetase is an enzyme (EC 4.2.1.20) that catalyzes the final two steps in the biosynthesis of tryptophan. It is commonly...

arginyl-tRNA synthetase, arginyl-transfer ribonucleate synthetase, arginyl-transfer RNA synthetase, arginyl transfer ribonucleic acid synthetase, arginine-tRNA...

called Lysyl-tRNA synthetase) is an enzyme that in humans is encoded by the KARS1 gene (previously KARS). Aminoacyl-tRNA synthetases are a class of enzymes...

Phosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) is the fifth enzyme (EC 6.3.3.1) in the de novo synthesis of purine nucleotides. It catalyzes...

2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene. This gene encodes a member of the 2-5A synthetase family, which include...

phosphate by phosphoribosylaminoimidazolesuccinocarboxamide synthetase (SAICAR synthetase) represents the eighth step of de novo purine nucleotide biosynthesis...

Carbamoyl phosphate synthetase III (CPS III) is one of the three isoforms of the carbamoyl phosphate synthetase, an enzyme that catalyzes the active production...

Phosphoribosylamine—glycine ligase, also known as glycinamide ribonucleotide synthetase (GARS), (EC 6.3.4.13) is an enzyme that catalyzes the chemical reaction...

Valyl-tRNA synthetase 2, mitochondrial is a protein that in humans is encoded by the VARS2 gene. This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which...

The aminoacyl-tRNA synthetases catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These...

Carbamoyl phosphate synthetase (glutamine-hydrolysing) (EC 6.3.5.5) is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in the cytosol...

In molecular biology, 2'-5'-oligoadenylate synthetase (2-5A synthetase) is an enzyme (EC 2.7.7.84) that reacts to interferon signal. It is an antiviral...

Alanyl—tRNA synthetase 1 (AARS1) is an enzyme that is encoded by the AARS1 gene in humans and is a member of the aminoacyl-tRNA synthetases (ARSs) family...

Cysteinyl-tRNA synthetase 1 is an enzyme (EC 6.1.1.16) that in humans is encoded by the CARS1 gene. It is an aminoacyl tRNA synthetase that attaches the...

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 is a protein that in humans is encoded by the AIMP1 gene. The protein encoded by...

Terpenyl pyrophosphate synthetase may refer to: All-trans-octaprenyl-diphosphate synthase, an enzyme All-trans-decaprenyl-diphosphate synthase, an enzyme...

(gene), isoleucine-specific transfer ribonucleate lysidine synthetase, tRNAIle-lysidine synthetase) is an enzyme with systematic name L-lysine:tRNAIle2–cytidine34...

glutamyl-prolyl tRNA synthetase (EPRS). This protein domain has an important function in protein–protein interactions between synthetases. WHEP domains exhibit...

synthetase, 4-coumarate:coenzyme A ligase, caffeoyl coenzyme A synthetase, p-hydroxycinnamoyl coenzyme A synthetase, feruloyl coenzyme A synthetase,...

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase (EC 6.3.2.13, MurE synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate...

UMPS Identifiers Aliases UMPS, OPRT, uridine monophosphate synthetase External IDs OMIM: 613891; MGI: 1298388; GeneCards: UMPS Available structures PDB...

Valyl-tRNA synthetase is an enzyme that in humans is encoded by the VARS1 gene (previously VARS). Aminoacyl-tRNA synthetases catalyze the aminoacylation...

Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene. Aminoacyl-tRNA synthetases are a...

phosphoribosylaminoimidazole-succinocarboxamide synthetase, PurC, SAICAR synthetase, 4-(N-succinocarboxamide)-5-aminoimidazole synthetase, 4-[(N-succinylamino)carbonyl]-5-aminoimidazole...

37, 3-hydroxybenzoyl-CoA synthetase, 3-hydroxybenzoate-coenzyme A ligase (AMP-forming), 3-hydroxybenzoyl coenzyme A synthetase, 3-hydroxybenzoyl-CoA ligase)...

common use include cysteinyl-tRNA synthetase, cysteinyl-transferRNA synthetase, cysteinyl-transfer ribonucleate synthetase, and cysteine translase. This enzyme...

N-acetylglutamate synthetase may refer to: Amino-acid N-acetyltransferase Glutamate N-acetyltransferase Urea cycle N-Acetylglutamate synthase This set...

In enzymology, a NAD+ synthetase (EC 6.3.1.5) is an enzyme that catalyzes the chemical reaction ATP + deamido-NAD+ + NH3 ⇌ {\displaystyle \rightleftharpoons...

alanyl-tRNA synthetase, alanyl-transfer ribonucleate synthetase, alanyl-transfer RNA synthetase, alanyl-transfer ribonucleic acid synthetase, alanine-transfer...

fatty acid transport protein 1 SLC27A2 (FATP2) Very long-chain acyl-CoA synthetase SLC27A3 (FATP3) Solute carrier family 27 member 3 SLC27A4 (FATP4) Long-chain...

acid synthetase, pseudouridine monophosphate synthetase, 5-ribosyluracil 5-phosphate synthetase, pseudouridylate synthetase, upsilonUMP synthetase, and...

"prostaglandin synthase (PHS)", "prostaglandin synthetase (PHS)", and "prostaglandin-endoperoxide synthetase (PES)" are older terms still sometimes used...

A, Stone M, Baker MA (July 2021). "Flagellar export apparatus and ATP synthetase: Homology evidenced by synteny predating the Last Universal Common Ancestor"...

Aminoacyl-tRNA synthetases, class II is a family of proteins. These proteins catalyse the attachment of an amino acid to its cognate transfer RNA molecule...

3-Hydroxypropionyl-CoA synthase (EC 6.2.1.36, 3-hydroxypropionyl-CoA synthetase (AMP-forming), 3-hydroxypropionate-CoA ligase) is an enzyme with systematic...

synthetase, acyl-[acyl carrier protein] synthetase, acyl-ACP synthetase, acyl-[acyl-carrier-protein]synthetase, stearoyl-ACP synthetase, and acyl-acyl...

NM_001605 alanyl-tRNA synthetase AARS2 NM_020745 alanyl-tRNA synthetase 2, mitochondrial AARSD1 NM_001261434 alanyl-tRNA synthetase domain containing 1...

Tyrosyl-tRNA synthetase, cytoplasmic, also known as tyrosine-tRNA ligase, is an enzyme that in humans is encoded by the YARS gene. Living cells translate...

Bifunctional aminoacyl-tRNA synthetase is an enzyme that in humans is encoded by the EPRS1 gene (previously EPRS). Alternative splicing has been observed...

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) is an enzyme that in humans is encoded by the AIMP2 gene. AIMP2 is also...

Acyl-CoA synthetase medium chain family member 2A is a protein that in humans is encoded by the ACSM2A gene. This gene encodes a mitochondrial acyl-CoA...

Rhodanese is a mitochondrial enzyme that detoxifies cyanide (CN−) by converting it to thiocyanate (SCN−, also known as "rhodanate"). In enzymatology, the...

domain, is found in tRNA synthetase beta subunits, as well as in some non-tRNA synthetase proteins. Aminoacyl-tRNA synthetases can catalyse editing reactions...

encodes the enzyme glycyl-tRNA synthetase (GlyRS), which belongs to the class II group of aminoacyl-tRNA synthetases. This enzyme is essential in the...

diphthine—ammonia ligase (EC 6.3.1.14, diphthamide synthase, diphthamide synthetase) is an enzyme that catalyzes the chemical reaction ATP + diphthine + NH3...

2'-5'-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene. This gene encodes a member of the 2-5A synthetase family, essential...

synthetase, aspartyl ribonucleic synthetase, aspartyl-transfer RNA synthetase, aspartic acid translase, aspartyl-transfer ribonucleic acid synthetase...

Homocystinuria (HCU) is an inherited disorder of the metabolism of the amino acid methionine due to a deficiency of cystathionine beta synthase or methionine...

cell cytosol and consists of two steps: first, the enzyme aminoacyl tRNA synthetase catalyzes the binding of adenosine triphosphate (ATP) to a corresponding...

In enzymology, an indoleacetate—lysine synthetase (EC 6.3.2.20) is an enzyme that catalyzes the chemical reaction ATP + (indol-3-yl)acetate + L-lysine...

Flavin adenine dinucleotide synthetase 1 is a protein that in humans is encoded by the FLAD1 gene. This gene encodes the enzyme that catalyzes adenylation...

3-Hydroxy-3-methylglutaryl-CoA lyase (or HMG-CoA lyase) is an enzyme (EC 4.1.3.4 that in human is encoded by the HMGCL gene located on chromosome 1. It...

Methionyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the MARS1 gene (formally MARS). Aminoacyl-tRNA synthetases are a class of...

Ribose-phosphate diphosphokinase (or phosphoribosyl pyrophosphate synthetase or ribose-phosphate pyrophosphokinase) is an enzyme that converts ribose 5-phosphate...

Threonyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the TARS1 gene. Aminoacyl tRNA synthetases catalyze the aminoacylation...

persistence in stressful environments. SpoT can act as both a hydrolase and a synthetase to (p)ppGpp alarmones in the stringent response pathway with Mn2+ as its...

carboxylyl-CoA synthetase, and dicarboxylyl-CoA synthetase. Vamecq J, de Hoffmann E, Van Hoof F (1985). "The microsomal dicarboxylyl-CoA synthetase". Biochem...

Aminoacyl-tRNA synthetase, which are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to...

ATP and triphosphate (P3) through the action of acetyl—CoA synthetase. Acetyl—CoA synthetase also produces adenosine 5'-pentaphosphate through the reaction...

Lipoic acid synthetase is a protein that in humans is encoded by the LIAS gene. The protein encoded by this gene belongs to the biotin and lipoic acid...

SARS and cytoplasmic seryl-tRNA synthetase are a human gene and its encoded enzyme product, respectively. SARS belongs to the class II amino-acyl tRNA...

Arginyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the RARS gene. Aminoacyl-tRNA synthetases catalyze the aminoacylation of...

Phenylalanyl-tRNA synthetase alpha chain is an enzyme that in humans is encoded by the FARSA gene. Aminoacyl-tRNA synthetases are a class of enzymes that...

CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl coenzyme A synthetase, cholic thiokinase, cholate thiokinase, cholic acid:CoA...

phosphopantothenate—cysteine ligase also known as phosphopantothenoylcysteine synthetase (PPCS) is an enzyme (EC 6.3.2.5) that catalyzes the chemical reaction...

glycinamide ribonucleotide synthase (GARS) and aminoimidazole ribonucleotide synthetase (AIRS). This protein (110kDa) catalyzes steps 2, 3 and 5 of de novo purine...

ASS (gene), a human gene that encodes for the enzyme argininosuccinate synthetase Ass (M), in abstract algebra, denotes the collection of all associated...

significantly different peptide substrate. Using PACE, aminoacyl-tRNA synthetases (aaRSs) were evolved for noncanonical amino acids as well. Activity of...

teichoic-acid synthase, polyribitol phosphate synthetase, teichoate synthetase, poly(ribitol phosphate) synthetase, polyribitol phosphate polymerase, and teichoate...

regulating the gene translationally. aspS genes encode aminoacyl tRNA synthetases. T-box leader RNAs detect low levels of various amino acids, and regulate...

also known as arginosuccinate synthetase deficiency, is a rare disease caused by a deficiency in argininosuccinate synthetase, an enzyme involved in excreting...

coenzyme A synthetase, succinate-phosphorylating enzyme, P-enzyme, SCS, G-STK, succinyl coenzyme A synthetase (GDP-forming), succinyl CoA synthetase, and succinyl...

synthesis of pyrimidines. Its enzymatic counterpart, carbamoyl phosphate synthetase I (CPS I), interacts with a class of molecules called sirtuins, NAD dependent...

unused codon to adopt, a tRNA that recognizes this codon, and a tRNA synthetase that recognizes only that tRNA and only the non-standard amino acid. Expanding...

type I citrullinemia. The enzyme made by this gene, argininosuccinate synthetase (EC 6.3.4.5), is responsible for one step of the urea cycle. Mutations...

(AMP-forming). Other names in common use include oxalyl-CoA synthetase, and oxalyl coenzyme A synthetase. This enzyme participates in glyoxylate and dicarboxylate...

Seryl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the SARS2 gene. ENSG00000283104 GRCh38: Ensembl release 89: ENSG00000104835...

manganese is bound to manganese metalloproteins, most notably glutamine synthetase in astrocytes. Manganese in the form of the deep violet salt potassium...

as follows: as malonyl-CoA synthetase: ATP + malonate + CoA → AMP + diphosphate + malonyl-CoA as methylmalonyl-CoA synthetase: ATP + methylmalonate + CoA...

Alanyl—tRNA synthetase, mitochondrial, also known as alanine—tRNA ligase (AlaRS) or alanyl—tRNA synthetase 2 (AARS2), is an enzyme that in humans is encoded...

names in common use include: formyltetrahydrofolate synthetase, 10-formyltetrahydrofolate synthetase, tetrahydrofolic formylase, and tetrahydrofolate formylase...

Tyrosine–tRNA ligase (EC 6.1.1.1), also known as tyrosyl-tRNA synthetase is an enzyme that is encoded by the gene YARS. Tyrosine–tRNA ligase catalyzes...

Stadtman, E. R. (1966). "Regulation of glutamine synthetase. I. purification and properties of glutamine synthetase from Escherichia coli". Arch. Biochem. Biophys...

acetoacetate:CoA ligase (AMP-forming). This enzyme is also called acetoacetyl-CoA synthetase. This enzyme participates in butanoate metabolism. Fukui T, Ito M, Tomita...

agents such as sulfonamides target dihydropteroate synthetase. The effect of dihydropteroate synthetase inhibition is comparable to that of dihydrofolate...

pyrimidines. It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarbamoylase. Dihydroorotase is a zinc metalloenzyme...

be aminoacylated. When a tRNA reaches an aminoacyl tRNA synthetase, the job of the synthetase is to join the t-shaped RNA with its amino acid. These aminoacylated...

gene. Glutamate–cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme...

Acyl-coenzyme A synthetase short-chain family member 2 is an enzyme that in humans is encoded by the ACSS2 gene. This gene encodes a cytosolic enzyme that...

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene. The protein encoded by this gene is an isozyme of very long-chain...

process. Note that, originally, biochemical nomenclature distinguished synthetases and synthases. Under the original definition, synthases do not use energy...

include glutamine-synthetase adenylyltransferase, ATP:glutamine synthetase adenylyltransferase, and adenosine triphosphate:glutamine synthetase adenylyltransferase...

(GDP-forming). Other names in common use include acyl-CoA synthetase (GDP-forming), and acyl coenzyme A synthetase (guanosine diphosphate forming). Rossi CR, Gibson...

include acetylhistidine synthetase, and histidine acetyltransferase. Baslow MH (December 1966). "N -acetyl-L-histidine synthetase activity from the brain...

Aspartyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the DARS gene. Aspartyl-tRNA synthetase (DARS) is part of a multienzyme...

in an ATP-dependent reaction catalyzed by a single enzyme, cyanophycin synthetase. Cyanophycin is of potential interest to biotechnology as a source of...

Singer SC, Ferone R (1985). "Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase Cloning and high expression of the Escherichia coli folC...

These genes include multiple genes encoding a number of aminoacyl tRNA synthetases, enzymes that catalyze the esterification of specific amino acids or...

5-MeO-αMT, also known as 5-methoxy-α-methyltryptamine or as α,O-dimethylserotonin (α,O-DMS or Alpha-O), is a psychedelic drug of the tryptamine, α-alkyltryptamine...

In molecular biology, adenylosuccinate synthase (or adenylosuccinate synthetase) (EC 6.3.4.4) is an enzyme that plays an important role in purine biosynthesis...

Triacsin C is an inhibitor of long fatty acyl CoA synthetase that has been isolated from Streptomyces aureofaciens. It blocks β-cell apoptosis, induced...

methionyl-tRNA synthetase, methionyl-transfer ribonucleic acid synthetase, methionyl-transfer ribonucleate synthetase, methionyl-transfer RNA synthetase, methionine...

include 4-hydroxybenzoate-CoA synthetase, 4-hydroxybenzoate-coenzyme A ligase (AMP-forming), 4-hydroxybenzoyl coenzyme A synthetase, and 4-hydroxybenzoyl-CoA...

7-phosphate synthetase, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase,...

synthetase, biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase, beta-methylcrotonyl coenzyme A holocarboxylase synthetase, and...

lysyl-tRNA synthetase, lysyl-transfer ribonucleate synthetase, lysyl-transfer RNA synthetase, L-lysine-transfer RNA ligase, lysine-tRNA synthetase, and lysine...

59 kDa 2'-5'-oligoadenylate synthetase-like protein is an enzyme that in humans is encoded by the OASL gene. It enhances antiviral innate immunity by acting...

to give amides. Active esters are prominent in biochemistry. Glutamine synthetase is an enzyme that forms an active ester from the terminal carboxylate...

caused by a mutation in a gene DARS1, which encodes protein aspartyl-tRNA synthetase, cytoplasmic. According to studies, the hypomorphic variant of DARS1 causes...

1975). "Regulation of synthesis of hepatic fatty acid synthetase: binding of fatty acid synthetase antibodies to polysomes". Proceedings of the National...

in common use include N5-ethyl-L-glutamine synthetase, theanine synthetase, and N5-ethylglutamine synthetase. Sasaoka K; Kito M (1964). "Synthesis of theanine...

aminoacyl-tRNA synthetases (AATRSs): These enzymes are responsible for attaching amino acids to their corresponding tRNAs Nucleotide synthetases: This group...

"Amino acid sequence of a phosphorylation site in skeletal muscle glycogen synthetase". Biochem. Biophys. Res. Commun. 75 (3): 643–50. Bibcode:1977BBRC...75...

4-hydroxyphenylpyruvic acid (4-HPP) via a nonribosomal peptide synthetase-like enzyme (atromentin synthetase), containing the domain architecture...

Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase. Anti-Jo1 von Tigerstrom...

decaprenyl pyrophosphate synthetase, polyprenylpyrophosphate synthetase, terpenoidallyltransferase, terpenyl pyrophosphate synthetase, trans-prenyltransferase)...

synthase (L-arginine-adding) (EC 6.3.2.30, CphA, CphA1, CphA2, cyanophycin synthetase, multi-L-arginyl-poly-L-aspartate synthase) is an enzyme with systematic...

respective aa-tRNA. Every amino acid has its own specific aminoacyl-tRNA synthetase, which is utilized to chemically bind to the tRNA that it is specific...

dimethylallyltryptophan synthetase, dimethylallylpyrophosphate:tryptophan dimethylallyl transferase, DMAT synthetase, and 4-(gamma,gamma-dimethylallyl)tryptophan...

Acyl-CoA synthetase medium-chain family member 3 (ACSM3) is a mitochondrial enzyme that in humans is encoded by the ACSM3 gene. GRCh38: Ensembl release...

Glutamate-ammonia ligase (glutamine synthetase) pseudogene 4 is a protein that in humans is encoded by the GLULP4 pseudogene. GRCh38: Ensembl release 89:...

CoA-ligase pathway, CoA can displace AMP to form luciferyl CoA. Fatty acyl-CoA synthetase similarly activates fatty acids with ATP, followed by displacement of...

These include deficiencies in the enzymes holocarboxylase synthetase. Holocarboxylase synthetase deficiency prevents the body's cells from using biotin effectively...

valyl-tRNA synthetase, valyl-transfer ribonucleate synthetase, valyl-transfer RNA synthetase, valyl-transfer ribonucleic acid synthetase, valine transfer...

bonds with simultaneous breakdown of ATP X + Y + ATP → XY + ADP + Pi Synthetase EC 7 Translocases Catalyse the movement of ions or molecules across membranes...

chapters. Her expertise is in protein:RNA interactions and aminoacyl tRNA synthetases. As of 2019, she is the Vice Chancellor for Research and Innovation at...

glycogen synthetase gene (GYS2) cause glycogen-storage disease type 0. The gene is located on chromosome band 12p12.2.[citation needed] Glycogen synthetase catalyzes...

acting as a high affinity inhibitor of the enzyme glutamyl-prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged...

Other names in common use include 6-carboxyhexanoyl-CoA synthetase, and pimelyl-CoA synthetase. This enzyme participates in biotin metabolism. Izumi Y...

an protein that in humans is encoded by the CPS1. Carbamoyl phosphate synthetase I, is a mitochondrial enzyme that catalyzes the first and rate-limiting...

C1-tetrahydrofolate synthase, mitochondrial also known as formyltetrahydrofolate synthetase, is an enzyme that in humans is encoded by the MTHFD1L gene (methylenetetrahydrofolate...

glutamate from glutamine and α-ketoglutarate, and thus along with glutamine synthetase (abbreviated GS) plays a central role in the regulation of nitrogen assimilation...

protonated and change its conformation to one that can bind to the F1Fo synthetase and stops it thereby preventing it from moving in a backwards direction...

enzymology, a malonate—CoA ligase (EC 6.2.1.76), also known as malonyl-CoA synthetase or malonate:CoA ligase (AMP-forming), is an enzyme that catalyzes the...

members of the Mur ligase family, including folylpolyglutamate synthetase, cyanophycin synthetase and the capB enzyme from Bacillales. This family includes...

Cobyrinate a,c-diamide synthase (EC [1]), cobyrinic acid a,c-diamide synthetase, CbiA (gene)) is an enzyme which catalyses the chemical reaction 2 ATP...

cell. Examples include pyruvate dehydrogenase, fatty acid synthetase, glutamine synthetase, proteasome, rubisco. A multienzyme complex that functions...

aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for...

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene. This gene encodes an enzyme included in the 2', 5' oligoadenylate...

gamma-glutaminylhistamine synthetase, and gamma-GHA synthetase. Stein C, Weinreich D (1982). "An in vitro characterization of gamma-glutamylhistamine synthetase: a novel...

with metabolic disorder, called the neonatal-onset carbamoyl phosphate synthetase I (CPS1) deficiency, he was given a genome tailored gene for CPS1 in 2025...

Early experiments elucidated the presence of non-ribosomal peptide synthetases, and subsequent purification and heterologous expression experiments...

kyotorphin synthetase. Ueda H, Yoshihara Y, Fukushima N, Shiomi H, Nakamura A, Takagi H (June 1987). "Kyotorphin (tyrosine-arginine) synthetase in rat brain...

acid corresponding to the codon it recognizes. The enzyme aminoacyl tRNA synthetase "charges" the tRNA molecules with the correct amino acids. The growing...

Dihydropteroate synthase inhibitors are drugs that inhibit the action of dihydropteroate synthase. They include sulfonamides, dapsone, and para-aminosalicylic...

6-phosphate synthase, trehalose 6-phosphate synthetase, trehalose phosphate synthase, trehalose phosphate synthetase, trehalose phosphate-uridine diphosphate...

serious neurological problems in males due to a malfunction of the PRPP synthetase 1 enzyme. Arts syndrome is part of a spectrum of PRPS-1 related disorders...

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 is an enzyme that in humans is encoded by the PAPSS2 gene. Sulfation is a common modification...

(EC 6.3.5.4, asparagine synthetase (glutamine-hydrolysing), glutamine-dependent asparagine synthetase, asparagine synthetase B, AS, AS-B) is an enzyme...

The UDP-forming form of cellulose synthase (EC 2.4.1.12) is the main enzyme that produces cellulose. Systematically, it is known as UDP-glucose:(1→4)-β-D-glucan...

L-aspartate CPS-1 carbamoyl phosphate synthetase I OTC Ornithine transcarbamoylase ASS argininosuccinate synthetase ASL argininosuccinate lyase ARG1 arginase...

Glutamate–cysteine ligase (GCL) EC 6.3.2.2), previously known as γ-glutamylcysteine synthetase (GCS), is the first enzyme of the cellular glutathione (GSH) biosynthetic...

biotinidase or holocarboxylase synthetase. These conditions respond to biotin. Forms include:[citation needed] Holocarboxylase synthetase deficiency - neonatal;...

include 'carnosine synthetase', 'carnosine-anserine synthetase', 'homocarnosine synthetase', and 'carnosine-homocarnosine synthetase'. The gene encoding...

leucyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the LARS2 gene. This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial...

monofunctional FAD synthetase differs from its prokaryotic counterpart, and is instead related to the PAPS-reductase family. The bacterial FAD synthetase that is...

include benzoate-coenzyme A ligase, benzoyl-coenzyme A synthetase, and benzoyl CoA synthetase (AMP forming). This enzyme participates in benzoate degradation...

(ADP-forming). Other names in common use include acetyl-CoA synthetase (ADP-forming), acetyl coenzyme A synthetase (adenosine diphosphate-forming), and acetate thiokinase...

ribonucleic acid synthetase, tryptophanyl-transfer RNA synthetase, tryptophanyl ribonucleic synthetase, tryptophanyl-transfer ribonucleic synthetase, tryptophanyl-tRNA...

Phosphoribosyl pyrophosphate synthetase-associated protein 1 is an enzyme that in humans is encoded by the PRPSAP1 gene. GRCh38: Ensembl release 89: ENSG00000161542...

Isoleucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the IARS1 gene. Aminoacyl-tRNA synthetases catalyze the aminoacylation...

are the first viruses reported to possess genes for amino-acyl tRNA synthetases for all 20 standard amino acids. The genus Tupanvirus was first described...

Information, U.S. National Library of Medicine. "Entrez Gene: TYMS thymidylate synthetase". "DNA: Form and Function" (PDF). Archived from the original (PDF) on...

synthetase, isoleucyl-transfer ribonucleate synthetase, isoleucyl-transfer RNA synthetase, isoleucine-transfer RNA ligase, isoleucine-tRNA synthetase...

and sucD genes. TrpS encodes tryptophanyl-tRNA-synthetase II and sucD encodes succinyl-coA-synthetase subunit alpha. Aar upregulates several mRNAs encoding...

Uroporphyrinogen III synthase (EC 4.2.1.75) is an enzyme involved in the metabolism of the cyclic tetrapyrrole compound porphyrin. It is involved in the...

synthetase, UDP-N-acetylmuramoyl-L-alanine synthetase, uridine diphospho-N-acetylmuramoylalanine synthetase, UDP-N-acetylmuramoylalanine synthetase,...

dihydrofolate synthetase, 7,8-dihydrofolate synthetase, H2-folate synthetase, 7,8-dihydropteroate:L-glutamate ligase (ADP), dihydrofolate synthetase-folylpolyglutamate...

is the case with N-acetylglutamate's activity on carbamoyl phosphate synthetase I, for example. A non-regulatory allosteric site is any non-regulatory...

acts as a potent and selective inhibitor of the bacterial leucyl-tRNA synthetase enzyme, and is currently in clinical trials. Li X, Hernandez V, Rock FL...

Phenylalanyl-tRNA synthetase, mitochondrial (FARS2) is an enzyme that in humans is encoded by the FARS2 gene. This protein encoded by FARS2 localizes to...

a compound that acts as an inhibitor of the GTPase enzyme leucyl-tRNA synthetase (LRS). This enzyme acts as part of the mTOR complex and acts as a leucine...

plants, because opisthokonts have a triple fusion of carbamoyl phosphate synthetase, dihydroorotase, and aspartate carbamoyltransferase that is not present...

Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the HARS2 gene. Aminoacyl-tRNA synthetases are a class of enzymes...

Other names in common use include indoleglycerol phosphate synthetase, indoleglycerol phosphate synthase, indole-3-glycerophosphate synthase...

3-dihydroxybenzoyl)-serine synthetase, and 2,3-dihydroxybenzoylserine synthetase. Brot N, Goodwin J (1968). "Regulation of 2,3-dihydroxybenzoylserine synthetase by iron"...

Ornithine translocase deficiency, also called hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, is a rare autosomal recessive urea cycle...

N-acetyl-L-glutamate synthetase may refer to: N-Acetylglutamate synthase Glutamate N-acetyltransferase This set index page lists enzyme articles associated...

para-aminobenzoic acid (PABA). They compete with PABA to bind to dihydropteroate synthetase and inhibit conversion of PABA and dihydropteroate diphosphate to dihydrofolic...

indels in a number of important proteins, such as Hsp70 and glutamine synthetase I; but the phylogeny of these genes was interpreted to reveal inter-domain...

has been determined. EEF1D has been shown to interact with Glycyl-tRNA synthetase, EEF1G and KTN1, and is predicted to interact with TMEM63A. ENSG00000273594...

synthase (EC 6.2.1.38, 2-oxo-Delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase) is an enzyme with systematic name ((1R)-2,2,3-trimethyl-5-oxocyclope...

alpha-isopropylmalate synthetase, alpha-isopropylmalate synthase, alpha-isopropylmalic synthetase, isopropylmalate synthase, and isopropylmalate synthetase. This enzyme...

synthesized by modular enzyme complexes called nonribosomal peptide synthetases. These complexes are often laid out in a similar fashion, and they can...

toxicity. Cyclosporin is synthesized by a nonribosomal peptide synthetase, cyclosporin synthetase. The enzyme contains an adenylation domain, a thiolation domain...

tRNA synthetases attach an aminoacid through esterification to the corresponding tRNA. The activation of amino acids it aminoacyl-tRNA synthetase requires...

of γ-glutamylcysteine. This condensation is catalyzed by glutathione synthetase. While all animal cells are capable of synthesizing glutathione, synthesis...

Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) Identifiers Symbol FDPS NCBI gene...

(AMP-forming). Bieganowski P, Pace HC, Brenner C (August 2003). "Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase...

Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved...

Tryptophanyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the WARS2 gene. Aminoacyl-tRNA synthetases catalyze the aminoacylation...

reaction, called tRNA charging, is catalyzed by aminoacyl tRNA synthetase. A specific tRNA synthetase is responsible for recognizing and charging a particular...

Biology, for research on the amino acid sequence of tryptophanyl tRNA synthetase from the bacterium Bacillus stearothermophilus in 1977 supervised by Brian...

O-succinylhomoserine synthase, O-succinylhomoserine synthetase, cystathionine synthase, cystathionine synthetase, homoserine transsuccinylase,...

cytidylyltransferase, CMP-3-deoxy-D-manno-octulosonate synthetase, CMP-KDO synthetase, CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase,...

is an anti-aminoacyl-tRNA synthetase (anti-ARS) antibody that targets its antigen, an enzyme called histidyl-tRNA synthetase (HARS) found in the cytoplasm...

MurE synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine, synthetase, and...

succinyl-CoA synthetase (ADP-forming), succinic thiokinase, succinate thiokinase, succinyl-CoA synthetase, succinyl coenzyme A synthetase (adenosine diphosphate-forming)...

Chymotrypsin 1.5 × 10−2 0.14 9.3 Pepsin 3.0 × 10−4 0.50 1.7 × 103 tRNA synthetase 9.0 × 10−4 7.6 8.4 × 103 Ribonuclease 7.9 × 10−3 7.9 × 102 1.0 × 105 Carbonic...

carboxyphosphate is a kinetically competent intermediate in the carbamyl phosphate synthetase reaction". The Journal of Biological Chemistry. 254 (6): 1854–1859. doi:10...

acid synthase (and not to be confused with long chain fatty acyl-CoA synthetase), is an enzyme complex responsible for fatty acid biosynthesis, and is...

At low glucose levels CoA is acetylated using acetate by acetyl-CoA synthetase (ACS), also coupled with ATP hydrolysis. Ethanol also serves as a carbon...

translating mRNA into protein. It is present as a domain of glutaminyl-tRNA synthetase (GlnRS) in almost all eukaryotes. The YqeY domain has been found to be...

octaprenyl pyrophosphate synthetase, polyprenylpyrophosphate synthetase, terpenoidallyltransferase, terpenyl pyrophosphate synthetase, trans-heptaprenyltranstransferase...

bifunctional enzyme: ATP-dependent monooxygenase and a long chain fatty acyl-CoA synthetase". FEBS Letters. 540 (1–3): 251–254. Bibcode:2003FEBSL.540..251O. doi:10...

called arachidonoyl-CoA synthetase. Wilson DB, Prescott SM, Majerus PW (1982). "Discovery of an arachidonoyl coenzyme A synthetase in human platelets". J...

Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate GSTooltip Glutamine synthetase 2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin...

biophysical chemistry. His research interests have focused on aminoacyl tRNA synthetases as fundamental interpreters of the genetic information. Through career-long...

protein is also called FATP4 or ACSVL5 (very long chain fatty acyl-CoA synthetase 5). The purified protein shows enzyme activity (EC 6.2.1.3), esterifying...

in common use include 7-keto-8-aminopelargonic acid synthetase, 7-keto-8-aminopelargonic synthetase, and 8-amino-7-oxopelargonate synthase. Eisenberg MA...

Molecular Biotechnolgy of Fungal beta-Lactam Antibiotics and Related Peptide Synthetases. Advances in Biochemical Engineering/Biotechnology. Vol. 88. Berlin,...

The acetoacetyl-CoA synthetase (AACS) gene encodes a protein of the same name, which converts acetoacetate to acetoacetyl-CoA, and plays a crucial role...

cannot occur without selenophosphate, which is produced by selenophosphate synthetase. Vertebrates including humans carry two versions of this enzyme, with...

inhibits glutamine synthetase. Thomas, M. D.; Langston-Unkefer, P. J.; Uchytil, T. F.; Durbin, R. D. (1983). "Inhibition of Glutamine Synthetase from Pea by...

Prostaglandin E synthase (EC 5.3.99.3, or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates...

homeostasis which regulates protein aggregation. methenyltetrahydrofolate synthetase (MTHFS) (provides substrate for C1THF synthase) Heat shock protein 70...

H, Nordlund P, et al. (July 2006). "Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy". Acta Crystallographica...

polynucleotide ligase (NAD+), DNA repair enzyme, DNA joinase, polynucleotide synthetase (nicotinamide adenine dinucleotide), deoxyribonucleic-joining enzyme,...

riboflavin biosynthesis proteins are also known as the prokaryotic type-I FAD synthetases, which consist of a C-terminal riboflavin kinase (RFK) and an N-terminal...

ligase 4 (FACL4), the protein encoded by the ACSL4 gene, is an acyl-CoA synthetase, which is an essential class of lipid metabolism enzymes, and ACSL4 is...

the histidine tRNA synthetase. The yeast guanylyl transferase specific to tRNAHis is unique in being the only known non-tRNA synthetase enzyme that specifically...

effects. Ap4A can be created by a non-canonical activity of the Lysyl-tRNA synthetase (LysRS). This function of LysRS is activated by the phosphorylation of...

Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 (MTHFD1) is a gene located in humans on chromosome 14 that encodes a...

2009). "Dissection of the structural organization of the aminoacyl-tRNA synthetase complex". The Journal of Biological Chemistry. 284 (10): 6053–60. doi:10...

Climate science Biochemistry Institutions NOAA Thesis Pyrrolysyl-tRNa synthetase recognition of tRNA(Pyl) in Desulfitobacterium hafniense and Methanosarcina...

and cephems. This path begins with a nonribosomal peptide synthetase (NRPS), ACV synthetase (ACVS), which generates the linear tripeptide...

synthase (EC 4.3.3.7, dihydrodipicolinate synthase, dihydropicolinate synthetase, dihydrodipicolinic acid synthase, L-aspartate-4-semialdehyde hydro-lyase...

synthetase, formylglycinamide ribonucloetide amidotransferase, phosphoribosylformylglycineamidine synthetase, FGAM synthetase, FGAR amidotransferase...

water L-threonine-forming). Other names in common use include threonine synthetase, and O-phospho-L-homoserine phospho-lyase (adding water). This enzyme...

Martinez-Sobrido, Luis; de la Torre, Juan Carlos (2026-02-04). "Prolyl tRNA Synthetase Is Required for Mammarenavirus Multiplication". Viruses. 18 (2): 202....

directly into glufosinate. The compound irreversibly inhibits glutamine synthetase, an enzyme necessary for the production of glutamine and for ammonia detoxification...

researching the extracellular functionality and signaling pathways of tRNA synthetases. The company's lead product candidate, ATYR1923, is a selective modulator...

discovered enzyme of Escherichia coli, is the B protein of quinolinate synthetase". J. Biol. Chem. 257 (2): 626–32. doi:10.1016/S0021-9258(19)68239-6. PMID 7033218...

synthetase, D-alanine:membrane-acceptor ligase, D-alanylalanylpoly(phosphoglycerol) synthetase, D-alanyl-poly(phosphoglycerol) synthetase, and D-alanine-membrane...

include: PRA isomerase, PRAI, IGPS:PRAI (indole-3-glycerol-phosphate, synthetase/N-5'-phosphoribosylanthranilate isomerase complex), and...

Yan JN (March 1974). "Properties and cellular localization of chitin synthetase in Phycomyces blakesleeanus". The Journal of Biological Chemistry. 249...

reductases, formate dehydrogenases, glycine reductases, selenophosphate synthetase 2, methionine-R-sulfoxide reductase B1 (SEPX1), and some hydrogenases)...

9-phosphate synthetase, N-acylneuraminate-9-phosphate pyruvate-lyase, (pyruvate-phosphorylating), and sialic acid 9-phosphate synthetase. This enzyme...

deprivation therapy for treating cancers deficient in argininosuccinate synthetase 1 (ASS1). It is a recombinant form of the enzyme arginine deiminase cloned...

Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene. Long-chain acyl-CoA synthetases such as ACSL6...

tryptophan (Escherichia coli)—anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase". Chorismate to tryptophan (Escherichia...

guanosine 5',3'-polyphosphate synthetase, (p)ppGpp synthetase I, (p)ppGpp synthetase II, guanosine pentaphosphate synthetase, GPSI, and GPSII. As of late...

CAD protein (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) is a trifunctional multi-domain enzyme involved in the first...

PA (Oct 1999). "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein"...

names in common use include MurF synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine, synthetase, UDP-N-acetylmuramoylalanyl-...

(ADP-forming). Other names in common use include malyl-CoA synthetase, malyl coenzyme A synthetase, and malate thiokinase. This enzyme participates in glyoxylate...

4.13), phosphoribosylglycinamide formyltransferase (EC 2.1.2.2), AIR synthetase (FGAM cyclase) (EC 6.3.3.1) activity which is required for de novo purine...

ER (August 1976). "DON, CONV and DONV-II. Inhibition of L-'asparagine synthetase in vivo". Biochemical Pharmacology. 25 (16): 1851–1858. doi:10.1016/0006-2952(76)90189-1...

deletions and point mutations which define functional domains in alanine tRNA synthetase (PhD thesis). Retrieved July 13, 2023. "Autobiography of Maria Jasin"...

more of the following enzymes: methylmalonyl-CoA mutase (MUT) acyl-CoA synthetase family member 3 (ACSF3) methylmalonyl-CoA epimerase (MCEE) enzymes involved...

enzyme asparagine synthetase produces asparagine, AMP, glutamate, and pyrophosphate from aspartate, glutamine, and ATP. Asparagine synthetase uses ATP to activate...

Cheng CY (Feb 1996). "Astrocytes synthesize and secrete prostaglandin D synthetase in vitro". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research...

lantibiotic synthetase component C-like 2 (bacterial)". Lu P, Hontecillas R, Philipson CW, Bassaganya-Riera J (Jun 2014). "Lanthionine synthetase component...

protein resource accession number Q46389 at UniProt. Dihydropteroate+synthetase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)...

gluconeogenesis. D-alanine-D-alanine ligase glutathione synthetase biotin carboxylase carbamoyl phosphate synthetase ribosomal protein S6 modification enzyme (RimK)...

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an enzyme that in humans is encoded by the PAPSS1 gene. Three-prime-phosphoadenosine...

transfer ribonucleate pseudouridine synthetase, pseudouridine synthase, and transfer RNA pseudouridine synthetase. As of late 2007, 4 structures have...

mitochondrial isoform of ACC1, and acyl-CoA synthetase family member 3 (ACSF3), a mitochondrial malonyl-CoA synthetase. MtACC1, like cytosolic ACC1 catalyses...

Lactose synthase (EC 2.4.1.22) is an enzyme that generates lactose from glucose and UDP-galactose. D-glucose + UDP-galactose       UDP       lactose It...

C-terminal in both DNA glycosylase/AP lyase enzymes and in isoleucyl tRNA synthetase. In these two types of enzymes, the C-terminal domain forms a zinc finger...

5-enolpyruvylshikimate 3-phosphate synthase Glyphosate Glycine N H 10 Inhibits glutamine-synthetase Glufosinate-ammonium Phosphinic acid O L 29 Inhibits cellulose synthesis...

ribonucleic, transformylase, formylmethionyl-transfer ribonucleic synthetase, methionyl ribonucleic formyltransferase, methionyl-tRNA Met formyltransferase...

by the non-ribosomal peptide synthetase of the heterodimer proteins CesA and CesB. In non-ribosomal peptide synthetase, individual amino acids are added...

anticodon, and the pylS gene, which encodes a class II aminoacyl-tRNA synthetase that charges the pylT-derived tRNA with pyrrolysine. It was originally...

syndrome Griscelli syndrome Type 1 (Elejalde syndrome) Holocarboxylase synthetase deficiency / Multiple carboxylase deficiency Krabbe disease Leigh's disease...

shuttle is a two-step process catalyzed by a family of isozymes of acyl-CoA synthetase that are found in the outer mitochondrial membrane, where they promote...

Other names in common use include leukotriene C4 synthetase, LTC4 synthase, LTC4 synthetase, leukotriene A4:glutathione S-leukotrienyltransferase...

4-Phosphopantoate—β-alanine ligase (EC 6.3.2.36, phosphopantothenate synthetase, TK1686 protein) is an enzyme with systematic name (R)-4-phosphopantoate:beta-alanine...

sulfoximine (MSO, also known as MetSox) is an irreversible glutamine synthetase inhibitor. It is the sulfoximine derivative of methionine with convulsant...

Sunghoon Kim has been studying novel functions of human aminoacyl-tRNA synthetases (ARSs) and searching for their pathophysiological connections to human...

attachment to the tRNA 3' end is catalysed by enzymes called aminoacyl tRNA synthetases. During protein synthesis, tRNAs with attached amino acids are delivered...

(CDPdiglyceride):L-serine O-phosphatidyltransferase, phosphatidylserine synthetase, CDP-diacylglycerol-L-serine O-phosphatidyltransferase, cytidine...

Interferon Signaling promotes the activation of a 2'-5'-oligoadenylate synthetase, sensitive to the presence of dsRNA longer than 15 base pairs. Because...

The process mainly involves 3 enzymes: clavaminate synthase, β-lactam synthetase, and N2-(2-carboxyethyl)-L-arginine (CEA) synthase. Clavaminate synthase...

chitin-uridine diphosphate acetylglucosaminyltransferase, chitin synthetase, and trans-N-acetylglucosaminosylase. This enzyme participates in aminosugars...

an enzyme with this activity is carbamoyl phosphate synthetase, e.g. carbamoyl phosphate synthetase I carrying out the first step of the urea cycle in...

nonribosomal peptides which are synthesized by non-ribosomal peptide synthetases. Both eukaryotes and prokaryotes can incorporate selenocysteine into...

gene. Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific...

gramicidin S synthetase. Gramicidin S biosynthetic pathway consists of two-enzyme of nonribosomal peptide synthases (NRPSs), gramicidin S synthetase I (GrsA)...

Scott AI (August 1979). "Purification and properties of strictosidine synthetase (an enzyme condensing tryptamine and secologanin) from Catharanthus roseus...

peptide synthetases (NRPS), similar to enterobactin. However, unlike enterobactin, the genes responsible for encoding the bacillibactin synthetases are all...

phenylalanine-tRNA synthetase beta subunits. This domain has been shown to bind DNA through a winged helix-turn-helix motif. Phenylalanine-tRNA synthetase may influence...

match any Rfam family. Downstream genes are either S-adenosylmethionine synthetase (most frequently), S-ribosylhomocysteine lyase, O-acetylhomoserine (thiol)-lyase...

activating enzyme, fatty acyl coenzyme A synthetase, medium chain acyl-CoA synthetase, butyryl-coenzyme A synthetase, L-(+)-3-hydroxybutyryl CoA ligase,...

adenosine triphosphate-riboflavine mononucleotide transadenylase FAD synthetase riboflavin adenine dinucleotide pyrophosphorylase Hayashi, Hideyuki (2013)...

as 70%, though some may have a low GC content. Analysis of glutamine synthetase sequence has been suggested for phylogenetic analysis of the Actinomycetota...

Catalytic Flexibility of tRNAIle-lysidine Synthetase Can Generate Alternative tRNA Substrates for Isoleucyl-tRNA Synthetase". Journal of Biological Chemistry...

(GTP) through substrate-level phosphorylation catalyzed by succinyl-CoA synthetase, as succinyl-CoA is converted to succinate, three equivalents of NADH...

angstrom crystal structure of Bacillus stearothermophilus tryptophanyl-tRNA synthetase complexed to its adenylate, tryptophanyl-5'AMP (1993) Doctoral advisors...

citrate:CoA ligase (ADP-forming). Other names in common use include citryl-CoA synthetase, citrate:CoA ligase, and citrate thiokinase. This enzyme participates...

methionine analogues into proteins in vivo by altering the methionyl-tRNA synthetase activity of a bacterial expression host. umass.edu (PhD thesis). University...

2014. The medication inhibits an essential fungal enzyme, leucyl-tRNA synthetase, that is required for protein synthesis. The inhibition of protein synthesis...

Lysergic acid (LA) is the substrate of lysergyl peptide synthetase, a nonribosomal peptide synthetase, which covalently links LA to the amino acids, L-alanine...

Long-chain fatty acid transport protein 1 (FATP1) is a protein that in humans is encoded by the SLC27A1 gene. The SLC27A1 gene is located on the 19th chromosome...

experimental drug which acts as an activator of the protein Lanthionine Synthetase C-like 2 (LANCL2). It has antiinflammatory effects and shows efficacy...

biosynthesis of codinaeopsin involves a polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) hybrid. The first step of the biosynthesis of codinaeopsin...

(PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. Subsequent...

Hexaprenyl diphosphate synthase (previously known as trans-pentaprenyltranstransferase) may refer to: Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate...

foods, it is present in mammals including humans. In mammals, acyl-CoA synthetase family member 3 (ACSF3) detoxifies malonic acid by converting it into...

Glutamine-dependent NAD(+) synthetase is an enzyme that in humans is encoded by the NADSYN1 gene. Nicotinamide adenine dinucleotide (NAD) is a coenzyme...

Acyl-CoA synthetase medium-chain family member 2B (ACSM2B) is a mitochondrial enzyme that in humans is encoded by the ACSM2B gene. GRCh38: Ensembl release...

Martinez-Sobrido, Luis; de la Torre, Juan Carlos (2026-02-04). "Prolyl tRNA Synthetase Is Required for Mammarenavirus Multiplication". Viruses. 18 (2): 202....

ammonium, which is then incorporated into amino acids using glutamine synthetase (GS) and glutamate synthase (GOGAT). Some microorganisms can use nitrate...

of nonribosomal protein synthetases (NRPSs). Its biosynthesis is via an enzymatic assembly consisting of 3 peptide synthetase proteins, TycA, TycB, and...

Promin, or sodium glucosulfone, is a sulfone drug that was investigated for the treatment of malaria, tuberculosis and leprosy. It is broken down in the...

palmitate in an ATP-dependent reaction, which is catalyzed by acyl-CoA synthetase. Further elongation occurs through the subsequent additions of malonyl-CoA...

In enzymology, a polynucleotide adenylyltransferase (EC 2.7.7.19) is an enzyme that catalyzes the chemical reaction ATP + RNA-3'OH ⇌ {\displaystyle \rightleftharpoons...

seryl-tRNA synthetase, SerRS, seryl-transfer ribonucleate synthetase, seryl-transfer RNA synthetase, seryl-transfer ribonucleic acid synthetase, and serine...

(AMP-forming). Other names in common use include asparagine synthetase, and L-asparagine synthetase. This enzyme participates in 3 metabolic pathways: alanine...

pathway and is synthesized from 5′-phosphoribosylformylglycinamidine by AIR synthetase. 5-aminoimidazole derivatives were considered unstable and therefore difficult...

peptide synthetases Lps2 and Lps3 (Figure 6). In addition to ergonovine and LAH, free lysergyl-alanine (liberated from the peptide synthetase without...

ligase (AMP-forming). This enzyme is also called acyl-protein synthetase. Riendeau D, Rodriguez A, Meighen E (1982). "Resolution of the fatty acid...

be used by the enzymes glutamate–cysteine ligase (GCL) and glutathione synthetase (GSS) to produce glutathione. Harris Ripps, Wen Shen (2012). "Review:...

protein and its C-terminus contains a region homologous to histidyl-tRNA synthetase (HisRS) next to the kinase catalytic moiety. This HisRS-like region forms...

Quinolinate synthase (EC 2.5.1.72, NadA, QS, quinolinate synthetase) is an enzyme with systematic name glycerone phosphate:iminosuccinate alkyltransferase...

The cause of this condition is a mutation in the SARS2 gene (seryl-tRNA synthetase enzyme) which has to do with protein translation. Furthermore, the HUPRA...

all coded by the same gene in CAD which consists of carbamoyl phosphate synthetase II, aspartate carbamoyltransferase and dihydroorotase. Dihydroorotate...

(1985). "Casbene synthetase: regulation of phytoalexin biosynthesis in Ricinus communis L. seedlings. Purification of casbene synthetase and regulation...

Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate GSTooltip Glutamine synthetase 2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin...

(January 1980). "Severe bleeding associated with defective thromboxane synthetase". Lancet. 1 (8160): 157. doi:10.1016/S0140-6736(80)90642-X. PMID 6101498...

leucine is mediated through Rag GTPases, leucine binding to leucyl-tRNA synthetase, leucine binding to sestrin 2, and possibly other mechanisms. Leucine...

Laine R, Yang E, et al. (September 2018). "5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly...

2-diacylglycerophosphate-cytidyl transferase, CTP-diacylglycerol synthetase, DAG synthetase, and CDP-DG. This enzyme participates in glycerophospholipid metabolism...

fluoroacetate. Fluoroacetate is first converted to fluoroacetyl-CoA by acetyl-CoA synthetase in the mitochondria. Then fluoroacetyl-CoA condenses with oxaloacetate...

pyrophosphate - catalyzed by phosphoribosylamine—glycine ligase (GAR synthetase). Due to the chemical lability of PRA, which has a half-life of 38 seconds...

H2BC12L: encoding histone H2B type F-S HLCS: encoding enzyme holocarboxylase synthetase (biotin-(propionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase) HMGN1:...

threonyl-tRNA synthetase, threonyl-transfer ribonucleate synthetase, threonyl-transfer RNA synthetase, threonyl-transfer ribonucleic acid synthetase, threonyl...

(forms an isopeptide bond, which is not a peptide bond) and glutathione synthetase (forms a peptide bond). A peptide bond can be broken by hydrolysis (the...

selection of amino acids during protein biosynthesis by the aminoacyl-tRNA synthetases, where he formulated the double-sieve editing mechanism. Fersht was one...

Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens...

Acyl-CoA synthetase short-chain family member 3 is a protein that in humans is encoded by the ACSS3 gene. ACSS3 is part of a family known as Acyl-CoA synthetases...

inhibition of inosine monophosphate dehydrogenase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis...

"Root of the Universal Tree of Life Based on Ancient Aminoacyl-tRNA Synthetase Gene Duplications". PNAS. 92 (7): 2441–2445. Bibcode:1995PNAS...92.2441B...

gene. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme...

following genes are implicated: LARS2, HARS2: two mitochondrial tRNA synthetase genes HSD17B4: involved in steroidogenesis and fatty acid metabolism TWNK:...

dermatomyositis, polymyositis, immune-mediated necrotising myopathy, anti-synthetase/overlap myositis and inclusion-body myositis. Acquired myopathies of systemic...

EC 6.2.1.55: E1 SAMP-activating enzyme Glutamine synthetase (EC 6.3.1.2) Argininosuccinate synthetase (EC 6.3.4.5) CTP synthase (EC 6.3.4.2) Pyruvate carboxylase...

and dephosphorylated structures of pig heart, GTP-specific succinyl-CoA synthetase". Journal of Molecular Biology. 299 (5): 1325–39. doi:10.1006/jmbi.2000...

of 652 residues with two catalytic domains. Its C-terminal domain is a synthetase and has an ATP-grasp family fold that is usually found in carbon-nitrogen...

Delta-1-pyrroline-5-carboxylate synthetase (P5CS) is an enzyme that in humans is encoded by the ALDH18A1 gene. This gene is a member of the aldehyde dehydrogenase...

antibiotics (except for tabtoxinine-β-lactam, which inhibits glutamine synthetase) bind to PBPs, which are essential for bacterial cell wall synthesis....

characteristics of ciprofibroyl-CoA synthetase in rat liver. Its possible identity with long-chain acyl-CoA synthetase". The Biochemical Journal. 284 (1):...

dehydrogenase, succinyl-CoA synthetase, fumarase, and malate dehydrogenase. The urea cycle is facilitated by carbamoyl phosphate synthetase I and ornithine transcarbamylase...

Zalkin H (July 1987). "Structural role for a conserved region in the CTP synthetase glutamine amide transfer domain". Journal of Bacteriology. 169 (7): 3023–8...

TCA cycle. The enzyme that catalyzes the reaction is argininosuccinate synthetase. Argininosuccinic acid is a precursor to fumarate in the citric acid cycle...

acetoacetyl-CoA. Acetoacetyl-CoA also behaves as a product of acetoacetyl-CoA synthetase (AACS) within the cytosol, using acetoacetate as the substrate, the reaction...

through a series of three main enzymes. These enzymes include acyl-CoA-synthetase, which converts the R-enantiomer to (−)-R-ibuprofen I-CoA; 2-arylpropionyl-CoA...

transport chain. Mitochondria in animal cells, possess two succinyl-CoA synthetases: one that produces GTP from GDP, and another that produces ATP from ADP...

gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation...

peptides reflects the imperfect selectivity of the associated aminoacyl-tRNA synthetase. In Miller–Urey experiments probing prebiotic synthesis of amino acids...

(ADP-forming). Other names in common use include 5,10-methenyltetrahydrofolate synthetase (MTHFS), formyltetrahydrofolic cyclodehydrase, and 5-formyltetrahydrofolate...

carboxylase] synthetase biotin-[acetyl coenzyme A carboxylase] synthetase acetyl coenzyme A holocarboxylase synthetase acetyl CoA holocarboxylase synthetase Biotin...

inhibition. They are competitive inhibitors of the enzyme dihydropteroate synthetase, DHPS. DHPS catalyses the conversion of PABA (para-aminobenzoate) to dihydropteroate...

beta-ketoacyl-ACP synthase I, beta-ketoacyl synthetase, beta-ketoacyl-ACP synthetase, beta-ketoacyl-acyl carrier protein synthetase, beta-ketoacyl-[acyl carrier protein]...

2009-09-19. Fall RR, West CA (1971). "Purification and properties of kaurene synthetase from Fusarium moniliforme". J. Biol. Chem. 246 (22): 6913–28. doi:10...

animals, and is important as it provides glutamate for the glutamine synthetase reaction. The systematic name of this enzyme class is L-glutamate:NADP+...

pubchem.ncbi.nlm.nih.gov. Retrieved 2023-01-26. "UMPS uridine monophosphate synthetase [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved...

substituents".[better source needed] The fumonisins inhibit ceramide synthetase, an enzyme[clarification needed] that converts sphingolipids to ceramides...

Sonoda T, Tatibana M (August 1983). "Purification of N-acetyl-L-glutamate synthetase from rat liver mitochondria and substrate and activator specificity of...

the succinyl-CoA to succinate conversion catalysed by the succinyl-CoA synthetase enzyme as part of the citric acid cycle; through exchanges of phosphate...

glutamyl-tRNA synthetase, glutamyl-transfer ribonucleate synthetase, glutamyl-transfer RNA synthetase, glutamyl-transfer ribonucleic acid synthetase, glutamate-tRNA...

contributed to the establishment of physiological importance of Aminoacyl tRNA synthetases beyond their classical role in supporting mRNA translation and their...

AL (March 1996). "DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages...

and wheezing. It selectively binds to inflamed tissues (Prostaglandin synthetase inhibitor) and is normally free of adverse systemic effects. Unlike other...

leucyl-tRNA synthetase, leucyl-transfer ribonucleate synthetase, leucyl-transfer RNA synthetase, leucyl-transfer ribonucleic acid synthetase, leucine-tRNA...

or pituitary gland, but it has shown tolmetin restrains prostaglandin synthetase in vitro and reduces plasma levels of prostaglandin E, possibly causing...

2'-5' oligoadenylate synthetase-like 2 is a protein that in the house mouse is encoded by the Oasl2 gene. The gene is also known as Oasl, M1204 and Mmu-OASL...

pyrophosphate synthetase-associated protein 2 is a protein that in humans is encoded by the PRPSAP2 gene. The enzyme phosphoribosyl pyrophosphate synthetase (PRS)...

Pyrrolysine—tRNAPyl ligase (EC 6.1.1.26, PylS, pyrrolysyl-tRNA synthetase) is an enzyme with systematic name L-pyrrolysine:tRNAPyl ligase (AMP-forming)...

common use include phosphoketotetrose aldolase, erythrulose-1-phosphate synthetase, erythrose-1-phosphate synthase, and erythrulose-1-phosphate formaldehyde-lyase...

Taurino G, Bianchi MG, Kilberg MS, Bussolati O (2020-01-09). "Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia". Frontiers in Oncology...

Phenylalanyl-tRNA synthetase beta chain is an enzyme that in humans is encoded by the FARSB gene. This gene encodes a highly conserved enzyme that belongs...

the treatment of cancer. The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis. Buthionine...

Conservation Service identifier FRSA FARSA (gene), the gene for a human RNA synthetase enzyme also abbreviated as FRSA This disambiguation page lists articles...

hydroxymethyltransferase (SHMT). It can then be consumed by methenyltetrahydrofolate synthetase (MTHFS) in another irreversible reaction to yield 5,10-methenyltetrahydrofolate...

is encoded by the FPGS gene. This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining...

The RNAs are often found upstream of genes that encode an acyl-tRNA synthetase that is specific for tryptophan. However, this association is not consistent...

phenylalanyl-tRNA synthetase, phenylalanyl-transfer ribonucleate synthetase, phenylalanine-tRNA synthetase, phenylalanyl-transfer RNA synthetase, phenylalanyl-tRNA...

Acyl-CoA Synthetase, Bubblegum Family, member 1 (ACSBG1) is an enzyme that in humans is encoded by the ACSBG1 gene. The protein encoded by this gene possesses...

Kava (Piper methysticum) Unknown Levodopa Ginger Inhibits thromboxane synthetase (in vitro) Anticoagulants Chamomile Unknown Benzodiazepines, barbiturates...

include MurD synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase, D-glutamate-adding...

the US FDA in 1948. Bacitracin is synthesised via nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not directly involved in its...

SW, et al. (August 2008). "AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53". Proceedings of the National...

Karl H. Muench, was titled, "Studies on prolyl transfer ribonucleic acid synthetase of escherichia coli". With the exception of two years spent researching...

6-phosphatase including glycogen storage disease; phosphoribosyl pyrophosphate synthetase, phosphoribosyl pyrophosphate amidotransferase; adenine phosphoribosyltransferase...

sialyltransferase, ganglioside GM3 synthetase, GM3 synthase, GM3 synthetase, and SAT 1. This enzyme participates in glycosphingolipid...

CHAP E. coli Bifunctional glutathionylspermidine synthetase/amidase In complex with Mg2+ and ADP and phosphinate inhibitor. Identifiers Symbol CHAP Pfam...

site of both tRNA synthetases (due to its double mimicry effect of alanine and proline), it is rejected by alanyl-tRNA synthetases post-transfer editing...

Thomas S. (2007). "Nucleotide Variation in the Cytidine Triphosphate Synthetase Gene of Giardia duodenalis". Journal of Eukaryotic Microbiology. 44 (6):...

trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase...

other N-terminal nucleophile (Ntn) hydrolases such as carbamoyl phosphate synthetase (CPSase). Nine invariant residues among the sequences of all Ntn amidotransferases...

4-methyleneglutamine synthetase. This enzyme participates in c5-branched dibasic acid metabolism. Winter HC, Su TZ, Dekker EE (1983). "4-methyleneglutamine synthetase: a...

Svetlana (2021). "Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases". RSC Chemical Biology. 2 (2): 468–485. doi:10.1039/d0cb00208a. PMC 8323819...

ribosomal protein L11 (rplK resp. relC) and the ribosome-associated (p)ppGpp synthetase I, RelA; deacylated tRNA bound in the ribosomal A-site is the primary...

Succinate is generated from succinyl-CoA by the enzyme succinyl-CoA synthetase in a GTP/ATP-producing step: Succinyl-CoA + NDP + Pi → Succinate + CoA...

Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate GSTooltip Glutamine synthetase 2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin...

synthesis from glutamate and ammonia is catalyzed by the enzyme glutamine synthetase. The majority of glutamine production occurs in muscle tissue, accounting...

ligase (AMP-forming). This enzyme is also called 2-furoyl coenzyme A synthetase. Koenig K, Andreesen JR (1989). "Molybdenum Involvement in Aerobic Degradation...

(gene), the human enzyme cytidine monophosphate N-acetylneuraminic acid synthetase Center for Mexican American Studies, an academic research center at University...

how well Rhodosporidium toruloides can express nonribosomal peptide synthetases. She showed that Rhodosporidium toruloides (a fungus) bioengineered to...

polyribonucleotide nucleotidyltransferase and guanosine pentaphosphate synthetase. One way M. tuberculosis becomes resistant to PZA is by disabling the...

8-cineole cyclase, geranyl pyrophoshate:1,8-cineole cyclase, 1,8-cineole synthetase) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase...

petrobactin is produced by a nonribosomal peptide synthetase independent siderophore (NIS) synthetase pathway,[jargon] in a pathway termed "Asb" for "anthrax...

triphosphate:pyrophosphate, phosphoribosyltransferase, phosphoribosyl ATP synthetase, phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase,...

o-succinylbenzoate-CoA synthase; o-succinylbenzoyl-coenzyme A synthetase; OSB-CoA synthetase; OSB: CoA ligase; synthetase, and o-succinylbenzoyle coenzyme A. The EC number...

Aminoacyl-tRNA Synthetases in Infectious Diseases and Targets for Therapeutic Development", in Kim, Sunghoon (ed.), Aminoacyl-tRNA Synthetases in Biology...

Acetyl activating enzyme may refer to: Acetyl-CoA synthetase, an enzyme Long-chain-fatty-acid—CoA ligase, an enzyme This set index page lists enzyme articles...

2021). "Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair". Cell Metabolism. 33 (10): 2076–2089.e9. doi:10...

added to 4′-phosphopantothenate by the enzyme phosphopantothenoylcysteine synthetase (PPCS; CoaB) to form 4'-phospho-N-pantothenoylcysteine (PPC). This step...

O-alanylphosphatidylglycerol synthase, and alanyl phosphatidylglycerol synthetase. Gould RM, Thornton MP, Liepkalns V, Lennarz WJ (1968). "Participation...

(1997). "Molecular cloning of cDNA encoding rat very long-chain acyl-CoA synthetase". J. Biol. Chem. 271 (48): 30360–5. doi:10.1074/jbc.271.48.30360. PMID 8939997...

1.1.27, O-phosphoseryl-tRNA ligase, non-canonical O-phosphoseryl-tRNA synthetase, SepRS) is an enzyme with systematic name O-phospho-L-serine:tRNACys ligase...

produced in an ATP-dependent reaction carried out by an aminoacyl tRNA synthetase. This aminoacyl-tRNA is then a substrate for the ribosome, which catalyzes...

be differentiated from NAA in vivo by MR spectroscopy at 3 tesla. NAAG synthetase activity mediates the biosynthesis of NAAG from glutamate and NAA, but...

Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate GSTooltip Glutamine synthetase 2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin...

most natural antibiotics. There are four known enzymes (lanthipeptide synthetases) responsible for producing lanthionine rings. Lantibiotics show substantial...

puerperium. Cases have been described in carbamoyl phosphate synthetase 1, argino-succinate synthetase and ornithine carbamoyltransferase deficiency. The most...

peptide synthetase systems in Gram-positive bacteria such as Paenibacillus polymyxa. Like other NRPs, polymyxins are assembled by synthetases with multiple...

the enzyme δ-(L-α-aminoadipyl)-L-cysteine-D-valine synthetase (ACVS), a nonribosomal peptide synthetase or NRPS. The second step in the biosynthesis of penicillin...

sorting-associated protein 13D VTCN1 (1p13) WARS2: Tryptophanyl-tRNA synthetase, mitochondrial WDR77 (1p13) YBX1 (1p34) ZCCHC17: zinc finger CCHC-type...

degradation. A reciprocal regulation of delta 1-pyrroline-5-carboxylate synthetase (P5CS) and proline dehydrogenase genes controls proline levels during...

Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate GSTooltip Glutamine synthetase 2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin...

antimetabolite and methionine antagonist. It is a substrate for methionyl-tRNA synthetase and is incorporated into proteins. Ethionine has been found to naturally...

Scott AI (August 1979). "Purification and properties of strictosidine synthetase (an enzyme condensing tryptamine and secologanin) from Catharanthus roseus...

the sequential condensation of amino acids by each modular unit of the synthetase. Amino acids are initially adenylated by an “adenylylation” (A) domain...

presence of neurotransmitter transporters and the expression of glutamine synthetase. However, there are distinguishing factors that put SGCs in their own...

polyketide synthase (PKS) in conjunction with a nonribosomal peptide synthetase (NRPS). The domains responsible for the biosynthesis of the linear polyketide...

deficiency (MCD) (which includes biotinidase deficiency and holocarboxylase synthetase deficiency) can also lead to inborn or late-onset forms of biotin deficiency...

Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria. It is also used to...

prostacyclin synthase, prostacyclin synthetase, prostagladin I2 synthetase, PGI2 synthase, PGIS, PTGIS, and PGI2 synthetase. Generally, protein–protein interactions...

P.; Forbes, C. D.; Prentice, C. R. (1983). "Dazoxiben, a thromboxane synthetase inhibitor, in the treatment of Raynaud's syndrome: A double-blind trial"...

isoprenoid biosynthesis. MECDP (2-C-methyl-D-erythritol 2,4-cyclodiphosphate) synthetase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis, isoprenoids...

signature indel consisting of a three-amino-acid insertion in isoleucine tRNA synthetase found only in the species of the genera Actinomyces and Mobiluncus. Actinomycota...

Hittner–Hirsch–Kreh syndrome HIV Hm syndrome HMG-CoA lyase deficiency HMG CoA synthetase deficiency Hodgkin lymphoma Hodgkin's disease Hoepffner–Dreyer–Reimers...

Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate GSTooltip Glutamine synthetase 2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin...

DR2 is also found in all patients that test positive for anti-Asn-RNA-synthetase and chronic interstitial lung disease. DR2 is linked to the HLA-DR51....

similarly either synthesized, or absorbed. The acyl-CoA comes from Acyl-CoA synthetase. The Shuttle's mechanism is as follows: Carnitine palmitoyltransferase...

PGF2α synthetase, prostaglandin 11-ketoreductase, prostaglandin D2-ketoreductase, prostaglandin F synthase, prostaglandin F synthetase, synthetase, prostaglandin...

regulator CP001562.1 2799nt/932aa 87 Bartonella tribocorum Alanyl-tRNA synthetase AM260525.1 2799nt/932aa 87 Methylobacterium nodulans Hypothetical protein...

its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1...

(ADP-forming). Other names in common use include asparagine synthetase (ADP-forming), and asparagine synthetase (adenosine diphosphate-forming). This enzyme participates...

unique codon (recoding) and a corresponding transfer-RNA:aminoacyl – tRNA-synthetase pair to encode it with diverse physicochemical and biological properties...

237300 - hyperammonemia due to carbamoyl phosphate synthetase I deficiency (carbamoyl phosphate synthetase I) Online Mendelian Inheritance in Man (OMIM):...

all forms of life. Typically, it is bound to coenzyme A by acetyl-CoA synthetase enzymes, where it is central to the metabolism of carbohydrates and fats...

Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate GSTooltip Glutamine synthetase 2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin...

Hensley K, Li G, Rao Z, Zhang XC (2009). "Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione". Genes...

protein kinase, phosphorylating and activating phosphoribosyl pyrophosphate synthetase 1 (PRPS1) to promote the de novo nucleic acid synthesis and live tumor...

significant dose German Shepherd dog Global Species Database Glutathione synthetase deficiency Glycogen storage disease GSD microscopy GSD chemical file format...

to a tRNA is known as tRNA charging. Here, the enzyme aminoacyl-tRNA-synthetase catalyzes two reactions. In the first one, it attaches an AMP molecule...

increases from 0.6 to 1.0, the citrate lyase and phosphoribosyl pyrophosphate synthetase, two enzymes controlling anabolic (ATP-demanding) pathways are activated...

Other names in common use include L-amino acid alpha-ligase, bacilysin synthetase, YwfE, and L-amino acid ligase. Tabata K, Ikeda H, Hashimoto S (2005)...

gaseous ammonia is absorbed into metabolic cells by the enzyme glutamine synthetase. To be able to absorb the few nutrients available on rocks or rocky substrates...

AABA/homoalanine (α-aminobutyric acid) – used by nonribosomal peptide synthetases BABA (β-aminobutyric acid) – known for its ability to induce plant disease...

projects make use of re-coded nonsense suppressor tRNA-Aminoacyl tRNA synthetase pairs from other organisms, though in most cases substantial engineering...

Aspartyl-tRNA Synthetase 2, Mitochondrial is an enzyme which is encoded by the gene DARS2. The DARS2 gene is located on the long arm (q) of chromosome...

adenosine group from ATP, a reaction catalyzed by S-adenosyl-methionine synthetase, to give S-adenosyl methionine (SAM). SAM is a widely used source of methyl...

manipulated cells. Sulfadiazine works by inhibiting the enzyme dihydropteroate synthetase. Side effects reported for sulfadiazine include nausea, loss of appetite...

enzyme Alanyl—tRNA synthetase 1 ACSF3: encoding enzyme Acyl-CoA synthetase family member 3 ACSM2B: encoding enzyme Acyl-coenzyme A synthetase ACSM2B, mitochondrial...

Hemalatha (2007-11-06). "Kinetic characterization of adenylosuccinate synthetase from the thermophilic archaea Methanocaldococcus jannaschii". Biochemistry...

M23 peptidase genes, but one is upstream of a gene whose product is NAD synthetase. However, there were two cases where no downstream gene was located. While...

synthase (L-aspartate-adding) (EC 6.3.2.29, CphA, CphA1, CphA2, cyanophycin synthetase, multi-L-arginyl-poly-L-aspartate synthase) is an enzyme with systematic...

Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate GSTooltip Glutamine synthetase 2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin...

1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents". The Journal of Biological...