Sixth Avenue Line may refer to any of the following transit lines in Manhattan, New York City:

• IRT Sixth Avenue Line, often called the Sixth Avenue Elevated or Sixth Avenue El, constructed in the 1870s, closed in 1938 and razed in 1939
• IND Sixth Avenue Line, a subway line established 1936–1940 to replace the Sixth Avenue Elevated
• Sixth Avenue Line (Manhattan surface), a streetcar line opened in 1852 and replaced in 1936 by bus service, later rerouted to Broadway and absorbed into the M5 route
• Uptown Hudson Tubes, a PATH line that was built in 1908 and is now located between the IND Sixth Avenue Line

This disambiguation page lists articles associated with the title Sixth Avenue Line.
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