KRT32

KRT32
Identifiers
Aliases	KRT32, HA2, HKA2, KRTHA2, hHa2, keratin 32
External IDs	OMIM: 602760; MGI: 1309995; HomoloGene: 68246; GeneCards: KRT32; OMA:KRT32 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,467,386 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,979,052 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; skin of arm; ; periodontal fiber; ; nipple; ; human penis; ; skin of abdomen; ; skin of leg; ; vagina; ; pharynx; ; cervix;
	Top expressed in
	lip; ; esophagus; ; superior surface of tongue; ; hair follicle; ; Ileal epithelium; ; skin of back; ; morula; ; urethra; ; skin of abdomen; ; extensor digitorum longus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity;
Cellular component	intermediate filament; extracellular exosome; cytosol;
Biological process	epidermis development; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3882
	16670
	ENSG00000108759
	ENSMUSG00000046095
	Q14532
	Q62168
	NM_002278
	NM_001159374; NM_010665
	NP_002269
	NP_001152846
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cuticular Ha2 is a protein that in humans is encoded by the KRT32 gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II hair keratin to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108759 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046095 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H, Schweizer J (Nov 1995). "Sequence data and chromosomal localization of human type I and type II hair keratin genes". Exp Cell Res. 220 (2): 357–62. doi:10.1006/excr.1995.1326. PMID 7556444.
^ Rogers MA, Winter H, Langbein L, Krieg T, Schweizer J (Dec 1996). "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5". J Invest Dermatol. 107 (4): 633–8. doi:10.1111/1523-1747.ep12584243. PMID 8823373.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT32 keratin 32".

Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S – 59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell. Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
Heid HW, Moll I, Franke WW (1988). "Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles". Differentiation. 37 (2): 137–57. doi:10.1111/j.1432-0436.1988.tb00805.x. PMID 2456239.

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