MYL1
Protein-coding gene in the species Homo sapiens
Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene .[ 5] [ 6] [ 7]
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000168530 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061816 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function" . Mol Cell Biol . 10 (3): 1095–104. doi :10.1128/mcb.10.3.1095 . PMC 360973 PMID 2304459 . ^ Cohen-Haguenauer O, Barton PJ, Nguyen VC, Serero S, Gross MS, Jegou-Foubert C, de Tand MF, Robert B, Buckingham M, Frezal J (Mar 1988). "Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter". Hum Genet . 78 (1): 65–70. doi :10.1007/BF00291237 . PMID 3422212 . S2CID 24782863 . ^ a b "Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast" .
Further reading
Kelly RG, Buckingham ME (2000). "Modular regulation of the MLC1F/3F gene and striated muscle diversity". Microsc. Res. Tech . 50 (6): 510–21. doi :10.1002/1097-0029(20000915)50:6<510::AID-JEMT8>3.0.CO;2-1 . PMID 10998640 . S2CID 26959819 . Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene . 66 (1): 135–46. doi :10.1016/0378-1119(88)90231-4 . PMID 2458299 . Seidel U, Arnold HH (1989). "Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle" . J. Biol. Chem . 264 (27): 16109–17. doi :10.1016/S0021-9258(18)71593-7 PMID 2777779 . Seidel U, Bober E, Winter B, et al. (1987). "The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3" . Nucleic Acids Res . 15 (12): 4989. doi :10.1093/nar/15.12.4989 . PMC 305934 PMID 3601661 . Kontrogianni-Konstantopoulos A, Huang SC, Benz EJ (2001). "A Nonerythroid Isoform of Protein 4.1R Interacts with Components of the Contractile Apparatus in Skeletal Myofibers" . Mol. Biol. Cell . 11 (11): 3805–17. doi :10.1091/mbc.11.11.3805 . PMC 15038 PMID 11071908 . Ballweber E, Galla M, Aktories K, et al. (2001). "Interaction of ADP-ribosylated actin with actin binding proteins" . FEBS Lett . 508 (1): 131–5. doi :10.1016/S0014-5793(01)03040-X PMID 11707283 . S2CID 7241702 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 .
